The DOI matches its Crossref record.
Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.
Abstract
Recent studies have identified a contiguous network of class II MHC-bearing dendritic cells (DC) in the airway epithelium of several species, including humans. This network seems comparable to the epidermal Langerhans cell population, comprising up to 700 DC per mm2 of airway epithelium. Moreover, it accounts for virtually all local immunostaining for class II MHC, suggesting an important role in surveillance for inhaled Ag. This study examines the turnover of these airway DC using a radiation chimera model that uses congenic rats expressing different allotypic variants of CD45, detectable via mAbs. Steady-state bone marrow renewal of the airway DC population (which is continuously depleted by migration of mature cells to draining lymph nodes) was interrupted via x-irradiation or high-dose dexamethasone, after which the resident population declined by 85% over the ensuing 72 h. After transplantation with congenic bone marrow and an initial lag period for graft establishment, the airway DC population was rapidly restored to preirradiation levels. These findings indicate a half-life of < or = 2 days for airway epithelial DC. In contrast, epidermal Langerhans cell half-life was > or = 15 days. The only comparable (short) half-life previously reported for a peripheral tissue DC population, is that derived from the gut wall. This indicates that rapidly turning over DC populations are a unique feature of the major "mucosal" organ systems, which is consistent with these DC playing an important role in surveillance of mucosal tissues for incoming Ag.
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“Many clinical studies have identified positive associations between levels of airway epithelial cell-derived inflammatory mediators and disease severity.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [114]
In the citing paper
“For instance, dose-related associations were found between several cytokines and chemokines (including IL-8/CXLC8, MIP-1α/CCL3, MCP-1/CCL2, and the IL-6/TNF-α ratio) in respiratory secretions and the severity of RSV bronchiolitis (76, 114, 271)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [114]
In the citing paper
“suggesting a relationship between overly aggressive innate immune responses and disease following infection.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [114]
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Self-citationThe Biology of Dendritic Cell Subsets in Allergen-Induced Asthma
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“By contrast, lung parenchymal DCs were only reduced by 50 percent at day 3 and 60 percent by day 6, and declined at a rate that was intermediate between airway and epidermal DC populations [122].”
Background
Metadata
- Authors
- Holt, P. G., Haining, S., Nelson, D. J., & Sedgwick, J. D.
- Affiliations
- The Kids Research Institute Australia (AU)
- Centenary Institute (AU)
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-07-01
- Volume
- 153
- Issue
- 1
- Pages
- 256-261
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1675056235
- Cited by
- 347
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 2 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 11 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 14
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- airway epithelium, radiation chimeras, Langerhans cells, mucosal immunity, X-ray irradiation
- MeSH terms
- Animals, Histocompatibility Antigens Class II, Dendritic Cells, Dexamethasone, Epithelial Cells, Langerhans Cells, Lung, Radiation Chimera, Trachea, X-Rays, Rats
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