Cited by 348Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

The DOI matches its Crossref record.

Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

Holt, P G, Haining, S, Nelson, D J, Sedgwick, J D·1994·The Journal of Immunology

Open this paper in CoChat — free account

Abstract

Recent studies have identified a contiguous network of class II MHC-bearing dendritic cells (DC) in the airway epithelium of several species, including humans. This network seems comparable to the epidermal Langerhans cell population, comprising up to 700 DC per mm2 of airway epithelium. Moreover, it accounts for virtually all local immunostaining for class II MHC, suggesting an important role in surveillance for inhaled Ag. This study examines the turnover of these airway DC using a radiation chimera model that uses congenic rats expressing different allotypic variants of CD45, detectable via mAbs. Steady-state bone marrow renewal of the airway DC population (which is continuously depleted by migration of mature cells to draining lymph nodes) was interrupted via x-irradiation or high-dose dexamethasone, after which the resident population declined by 85% over the ensuing 72 h. After transplantation with congenic bone marrow and an initial lag period for graft establishment, the airway DC population was rapidly restored to preirradiation levels. These findings indicate a half-life of < or = 2 days for airway epithelial DC. In contrast, epidermal Langerhans cell half-life was > or = 15 days. The only comparable (short) half-life previously reported for a peripheral tissue DC population, is that derived from the gut wall. This indicates that rapidly turning over DC populations are a unique feature of the major "mucosal" organ systems, which is consistent with these DC playing an important role in surveillance of mucosal tissues for incoming Ag.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.153.1.256

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 348

Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens
Wikström, M. E., & Stumbles, P. A. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100039 · Cited by 89
Targeted delivery of antigen to hamster nasal lymphoid tissue with M-cell-directed lectins
Giannasca, P. J., Boden, J. A., & Monath, T. P. C. (1997) · Infection and Immunity · doi:10.1128/iai.65.10.4288-4298.1997 · Cited by 89
“These antigens may be subsequently sampled by intraepithelial dendritic cells which are interspersed throughout this epithelium (21) and become antigen-presenting cells following migration from the mucosa to draining lymph nodes (22).”
Background
Airway Epithelial Cells Regulate the Functional Phenotype of Locally Differentiating Dendritic Cells: Implications for the Pathogenesis of Infectious and Allergic Airway Disease
Rate, A., Upham, J. W., Bosco, A., McKenna, K. L., & Holt, P. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.72 · Cited by 88
“over of these populations (13); this already dynamic process can be”
BackgroundSelf-citation
Skin sensitization quantitative risk assessment: A review of underlying assumptions
Basketter, D. A., & Safford, B. J. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.11.013 · Cited by 86
Interactions between innate and adaptive immunity in asthma pathogenesis: New perspectives from studies on acute exacerbations
Holt, P. G., & Strickland, D. H. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.02.011 · Cited by 85
“The steady-state dynamics of these mucosal cells are unique among DCs, with the AMDC population being renewed every 24 to 36 hours as antigen-laden cells emigrate to the draining lymph nodes and are replaced by incoming (immature) bone marrow–derived precursors.(11) This rapid turnover further accelerates during local…”
BackgroundSelf-citation
Long-lived immature dendritic cells mediated by TRANCE-RANK interaction
Cremer, I., Dieu-Nosjean, M.-C., Maréchal, S., Dezutter-Dambuyant, C., Goddard, S., Adams, D., Winter, N., Menetrier-Caux, C., Sautès-Fridman, C., Fridman, W. H., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0312 · Cited by 85
Current Understanding of Pneumocystis Immunology
Kelly, M. N., & Shellito, J. E. (2009) · Future Microbiology · doi:10.2217/fmb.09.116 · Cited by 85
Human Immature Dendritic Cells Efficiently Bind and Take up Secretory IgA Without the Induction of Maturation
Heystek, H. C., Moulon, C., Woltman, A. M., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.102 · Cited by 85
Cell-mediated Adaptive Immune Defense of the Lungs
Curtis, J. L. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200507-070js · Cited by 82
“In healthy lungs, iDC reside in airway epithelium, alveolar septae, and around pulmonary vessels (25) but rarely within alveoli.”
Background
Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: involvement of epithelial dendritic cells
McWilliam, A. S., Marsh, A. M., & Holt, P. G. (1997) · Journal of Virology · doi:10.1128/jvi.71.1.226-236.1997 · Cited by 83
Self-citation
Allergen-Induced Changes in Bone-Marrow Progenitor and Airway Dendritic Cells in Sensitized Rats
Lambrecht, B. N., Carro‐Muino, I., Vermaelen, K. Y., & PAUWELS, R. A. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.6.3484 · Cited by 79
Airway dendritic cells: Co‐ordinators of immunological homeostasis and immunity in the respiratory tract
Stumbles, P. A., Upham, J. W., & Holt, P. G. (2003) · Apmis · doi:10.1034/j.1600-0463.2003.11107806.x · Cited by 76
“ways (67) and the antigen presentation studies described above, supporting the concept of”
BackgroundSelf-citation
Dendritic cells, T cell tolerance and therapy of adverse immune reactions
Morel, P. A., Feili‐Hariri, M., Coates, P. T., & Thomson, A. W. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02161.x · Cited by 76
Glucocorticoid-Induced Apoptosis of Dendritic Cells in the Rat Tracheal Mucosa
Brokaw, J. J., White, G. W., Bałuk, P., Anderson, G. P., Umemoto, E. Y., & McDonald, D. M. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.4.2870 · Cited by 73
Lymphocytes in the lung: an often neglected cell: Numbers, characterization and compartmentalization
Pabst, R., & Tschernig, T. (1995) · Anatomy and Embryology · doi:10.1007/bf00710098 · Cited by 71
Role of tumour necrosis factor-α receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema
D'hulst, A. I., Bracke, K. R., Maes, T., Bleecker, J. D., Pauwels, R., Joos, G., & Brusselle, G. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00059305 · Cited by 71
Nitrogen Dioxide Promotes Allergic Sensitization to Inhaled Antigen
Bevelander, M., Mayette, J., Whittaker, L. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3680 · Cited by 71
“Although numerous DCs are present in the lung of naive mice under normal conditions (51, 52), they do not initiate a stimulatory adaptive immune response following inhalation of purified Ag to which the animal has not been sensitized.”
Background
Class I-restricted CTL induction by mucosal immunization with naked DNA encoding measles virus haemagglutinin.
Etchart, N., Kaiserlian, D., Wild, T., et al. (1997) · Journal of General Virology · doi:10.1099/0022-1317-78-7-1577 · Cited by 71
“In addition, mucosae of the respiratory and gastro-intestinal tract also contain DC, which have been reported to act as efficient APC for mucosally delivered protein antigens (Liu & MacPherson, 1993 ; Holt et al., 1994).”
Enemy at the gates: dendritic cells and immunity to mucosal pathogens
Soloff, A. C., & Barratt‐Boyes, S. M. (2010) · Cell Research · doi:10.1038/cr.2010.94 · Cited by 67
Pulmonary DNA vaccination: Concepts, possibilities and perspectives
Bivas‐Benita, M., Ottenhoff, T. H. M., Junginger, H. E., & Borchard, G. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.05.028 · Cited by 71
“inflammatory state), the turnover of pulmonary DCs further accelerates, indicating their importance in local antigen surveillance [43,44].”
Basement Membrane Pores in Human Bronchial Epithelium
Howat, W., Holmes, J. A., Holgate, S. T., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64009-6 · Cited by 69
An Immunologic Model for Rapid Vaccine Assessment — A Clinical Trial in a Test Tube
Higbee, R. G., Byers, A. M., Dhir, V., Drake, D., Gappa‐Fahlenkamp, H., Gangur, J., Kachurin, A., Kachurina, O., Leistritz, D. C., Ma, Y., et al. (2009) · Alternatives to Laboratory Animals · doi:10.1177/026119290903701s05 · Cited by 69
Pulmonary Dendritic Cells in Local Immunity to Inert and Pathogenic Antigens in the Respiratory Tract
Holt, P. G. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200502-017aw · Cited by 68
Self-citation
Enumeration of Antigen-Presenting Cells in Mice Infected with Sendai Virus
Usherwood, E. J., Hogg, T. L., & Woodland, D. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3350 · Cited by 68
“The lung has a contiguous network of MHC class II-positive dendritic cells (DCs) that turn over rapidly and may constantly sample the antigenic environment in the lungs and transport Ag to draining lymph nodes (4).”
Background
Lung Dendritic Cell Migration
Hammad, H., & Lambrecht, B. N. (2007) · Advances in immunology · doi:10.1016/s0065-2776(06)93007-7 · Cited by 67
Origin and functional specializations of DC subsets in the lung
Plantinga, M., Hammad, H., & Lambrecht, B. N. (2010) · European Journal of Immunology · doi:10.1002/eji.201040562 · Cited by 66
The Regulation of Pulmonary Immunity
Lipscomb, M. F., Bice, D. E., Lyons, C. R., Schuyler, M. R., & Wilkes, D. S. (1995) · Advances in immunology · doi:10.1016/s0065-2776(08)60634-3 · Cited by 65
The Lung as a Target Organ of Graft-Versus-Host Disease
Yanik, G. A., & Cooke, K. R. (2006) · Seminars in Hematology · doi:10.1053/j.seminhematol.2005.09.004 · Cited by 65
Sensitization to inhaled antigen by intratracheal instillation of dendritic cells
Lambrecht, B. N., Peleman, R. A., Bullock, & Pauwels (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00818.x · Cited by 64
Generalized immunosuppression: how viruses undermine the immune response
Naniche, D., & Oldstone, M. B. A. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000625 · Cited by 65
Development and homeostasis of ‘resident’ myeloid cells: the case of the Langerhans cell
Chorro, L., & Geissmann, F. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.09.003 · Cited by 64
Leukotriene A4 Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness
Rao, N. L., Riley, J. P., Banie, H., Xue, X., Sun, B., Crawford, S., Lundeen, K. A., Yu, F., Karlsson, L., Fourie, A. M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200807-1158oc · Cited by 62
“We gated on CD11c1 DCs, a marker expressed by both airway and parenchymal DCs that are known to be more endocytic and efficient at presenting peptides to T cells (40).”
Background
Dendritic Cells in the Pathogenesis of Sarcoidosis
Zaba, L. C., Smith, G. P., Sanchez, M., & Prystowsky, S. D. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0033tr · Cited by 63
“However, inflammatory lung DCs have a relatively short half-life of only 2 days (59).”
Background
Dendritic Cells and Langerhans Cells in the Uptake of Mucosal Antigens
MacPherson, G. G., & Liu, L. M. (1999) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59951-4_3 · Cited by 62
Characterization of Dendritic Cell Populations in the Respiratory Tract
Holt, P. G., & Stumbles, P. A. (2000) · Journal of Aerosol Medicine · doi:10.1089/jam.2000.13.361 · Cited by 60
Self-citation
Innate Immune Control of Pulmonary Dendritic Cell Trafficking
Cook, D. N., & Bottomly, K. (2007) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200701-026aw · Cited by 58
“Compared with their counterparts in the lung parenchyma, CD11chi cells in the airway are more endocytic, are more efficient at presenting peptides to naive T cells, and have a shorter half-life (15).”
Background
Airway Epithelial IL-15 Transforms Monocytes into Dendritic Cells
Regamey, N., Obregon, C., Ferrari‐Lacraz, S., van Leer‐Buter, C., Chanson, M., Nicod, L. P., & Geiser, T. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0235oc · Cited by 59
“Even in the absence of overt inflammation, DCs or their precursors are constantly being recruited from the blood into the lung, as first demonstrated by Holt and coworkers (4).”
Background
Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma
Hoffmann, F. S., Ender, F., Schmudde, I., Lewkowich, I. P., Köhl, J., König, P., & Laumonnier, Y. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00107 · Cited by 62
“CD103+ cDCs MHC-II+ intraepithelial DCs (115, 116) described in the trachea of the rat were later equated with the CD103+ cDC subset in the lung of mice (108).”
BackgroundResult
Functional modulation of dendritic cells to suppress adaptive immune responses
Woltman, A. M., & van Kooten, C. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0902431 · Cited by 56
“Under steady-state conditions, migration of DCs from blood to tissues and from tissues to lymph nodes is present but relatively low [10].”
Background
Dendritic Cell Precursors Are Enriched in the Vascular Compartment of the Lung
Suda, T., McCarthy, K. M., Vu, Q., McCormack, J. M., & Schneeberger, E. E. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.19.5.3214 · Cited by 54
Emerging role of dendritic cells in respiratory viral infection
Grayson, M. H., & Holtzman, M. J. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0212-3 · Cited by 55
“Conventional DCs develop in the bone marrow and travel to peripheral tissues in an immature state [7].”
BackgroundMethod
Who is really in control of skin immunity under physiological circumstances – lymphocytes, dendritic cells or keratinocytes?
Paus, R., Schröder, J. ‐., Reich, K., Kabashima, K., Liu, F. T., Romani, N., Metz, M., Kerstan, A., Lee, P. H. A., Loser, K., et al. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00506_1.x · Cited by 60
Programming for Responsiveness to Environmental Antigens That Trigger Allergic Respiratory Disease in Adulthood Is Initiated during the Perinatal Period
Holt, P. G. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106795 · Cited by 57
Self-citation
Dendritic cell dynamics in the liver and hepatic lymph
Matsunol, K., & Ezaki, T. (2000) · International review of cytology · doi:10.1016/s0074-7696(00)97003-7 · Cited by 55
Steroids inhibit uptake and/or processing but not presentation of antigen by airway dendritic cells
Holt, P. G., & Thomas, J. A. (1997) · Immunology · doi:10.1046/j.1365-2567.1997.00321.x · Cited by 55
Self-citation
Respiratory sensitization: toxicological point of view on the available assays
Chary, A., Hennen, J., Klein, S. G., Serchi, T., Gutleb, A. C., & Blömeke, B. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2088-5 · Cited by 57
The dendritic cell in allergic airway diseases: a new player to the game
Lambrecht, B. N. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01061.x · Cited by 54
Therapy and prophylaxis of inhaled biological toxins
Paddle, B. M. (2003) · Journal of Applied Toxicology · doi:10.1002/jat.903 · Cited by 54
T regulatory cells in childhood asthma
Strickland, D. H., & Holt, P. G. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.010 · Cited by 53
Self-citation
Bronchial response pattern of antigen presenting cells and regulatory T cells in children less than 2 years of age
Heier, I., Malmstrom, K., Pelkonen, A. S., Malmberg, L. P., Kajosaari, M., Turpeinen, M., Lindahl, H. G., Brandtzaeg, P., Jahnsen, F. L., & Mäkelä, M. J. (2008) · Thorax · doi:10.1136/thx.2007.082974 · Cited by 52
The biology of airway dendritic cells
McWILLIAM, A. S., Nelson, D. J., & Holt, P. G. (1995) · Immunology and Cell Biology · doi:10.1038/icb.1995.63 · Cited by 52
Self-citation
Pulmonary dendritic cell development and antigen acquisition
Desch, A. N., Henson, P. M., & Jakubzick, C. (2012) · Immunologic Research · doi:10.1007/s12026-012-8359-6 · Cited by 52
Reconstitution dynamics of plasmacytoid and myeloid dendritic cell precursors after allogeneic myeloablative hematopoietic stem cell transplantation
Fagnoni, F. F., Oliviero, B., Giorgiani, G., Stefano, P. D., Dehò, A., Zibera, C., Gibelli, N., Maccario, R., Prada, G. D., Zecca, M., et al. (2004) · Blood · doi:10.1182/blood-2003-07-2443 · Cited by 51
Influence of Mucosal Adjuvants on Antigen Passage and CD4+ T Cell Activation during the Primary Response to Airborne Allergen
Wikström, M. E., Batanero, E., Smith, M. E., Thomas, J. A., von Garnier, C., Holt, P. G., & Stumbles, P. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.913 · Cited by 51
“over in the respiratory mucosae (15), and respond to local infection”
BackgroundSelf-citation
CX3CR1+c-kit+ Bone Marrow Cells Give Rise to CD103+ and CD103− Dendritic Cells with Distinct Functional Properties
del Rio, M., Rodríguez-Barbosa, J.-I., Bölter, J., Ballmaier, M., Dittrich‐Breiholz, O., Kracht, M., Jung, S., & Förster, R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6178 · Cited by 48
“Dendritic cells (DC)(3) reside in peripheral tissues, such as the lung, and migrate under inflammatory as well as steady-state conditions to the regional lymph node, reflecting the continuous turnover process of these cells (2).”
Background
Long-Term Productive Human Immunodeficiency Virus Infection of CD1a-Sorted Myeloid Dendritic Cells
Popov, S., Chenine, A.-L., Gruber, A., Li, P., & Ruprecht, R. M. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.602-608.2005 · Cited by 56
“Earlier studies reported that Langerhans cells represent a long-lived cell population (15, 16, 18).”
Result
Visualization of Early APC/T Cell Interactions in the Mouse Lung Following Intranasal Challenge
Byersdorfer, C. A., & Chaplin, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6756 · Cited by 48
Chronic beryllium disease: a model interaction between innate and acquired immunity
Sawyer, R. T., Maier, L. A., Kittle, L. A., et al. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00177-1 · Cited by 48
Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells
Fernandez, M. V., Miller, E., Krammer, F., Gopal, R., Greenbaum, B. D., & Bhardwaj, N. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0614-313rrr · Cited by 49
“DCs are present in the epithelial lining of conductive airways and are also rapidly mobilized from circulation to bronchial tissue following inhalation of microbial agents [17–20].”
Background
The role of dendritic cells in asthma
Holt, P. G., & Upham, J. W. (2004) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200402000-00009 · Cited by 47
Self-citation
Phenotype and function of rat dendritic cell subsets
Yrlid, U., & MacPherson, G. G. (2003) · Apmis · doi:10.1034/j.1600-0463.2003.11107807.x · Cited by 43
Epidermal Receptor Activator of NF-κB Ligand Controls Langerhans Cells Numbers and Proliferation,
Barbaroux, J.-B., Beleut, M., Brisken, C., Mueller, C. G., & Groves, R. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1103 · Cited by 43
Functional studies on dendritic cells in the respiratory tract and related mucosal tissues
Holt, P. G., Stumbles, P. A., & McWilliam, A. S. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.2.272 · Cited by 42
“The high turnover rate of the airway DC subset was verified via plotting the rate of repopulation of the depleted epithelium by (congenic) donor DC after bone marrow transplantation [15].”
BackgroundInfluentialSelf-citation
The role of γδ T cells in the airways
Lahn, M. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000123 · Cited by 40
Entry sites for oral vaccines and drugs: A role for M cells, enterocytes and dendritic cells?
Kaiserlian, D., & Etchart, N. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0177 · Cited by 39
The Accumulation of Dendritic Cells in the Lung Is Impaired in CD18−/− But Not in ICAM-1−/− Mutant Mice
Schneeberger, E. E., Vu, Q., LeBlanc, B. W., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2472 · Cited by 40
“Their turnover in airway epithelium is rapid (11), approaching that of DC in the intestinal tract (12), thus necessitating their continuous replenishment by DC precursors released from the bone marrow.”
BackgroundInfluential
The respiratory immune system of pigs
Pabst, R. (1996) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(96)05700-5 · Cited by 38
Innate immunity to influenza in chronic airways diseases
Hsu, A., See, H. V., Hansbro, P. M., & Wark, P. A. B. (2012) · Respirology · doi:10.1111/j.1440-1843.2012.02200.x · Cited by 35
Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation
Swert, K. O. D., Bracke, K. R., Demoor, T., et al. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-37 · Cited by 36
“Macrophages and DCs are originally derived from monocyte precursors in the bone marrow [32,33].”
Background
CD1a+ and CD1a- Accessory Cells from Human Bronchoalveolar Lavage Differ in Allostimulatory Potential and Cytokine Production
van Haarst, J. M., Verhoeven, G. T., de Wit, H. J., et al. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.6.8969270 · Cited by 36
In Vitro Regulation of Dendritic Cell Development and Function
Caux, C., & Banchereau, J. (1996) · Blood cell biochemistry · doi:10.1007/978-0-585-31728-1_11 · Cited by 35
Epithelial, dendritic, and CD4+ T cell regulation of and by reactive oxygen and nitrogen species in allergic sensitization
Ckless, K., Hodgkins, S. R., Ather, J. L., Martin, R., & Poynter, M. E. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.005 · Cited by 37
“Dendritic cells (DCs) form a complex network along the airway and in the alveolus that interdigitate between epithelial cells to allow sampling of the airspace lumen to ingest and process inhaled and endogenously-generated material (58).”
Background
Airways infection with virulent Mycobacterium tuberculosis delays the influx of dendritic cells and the expression of costimulatory molecules in mediastinal lymph nodes
García-Romo, G. S., Pedroza‐González, A., Aguilar‐León, D., Orozco-Estévez, H., Lambrecht, B. N., Estrada‐García, I., Flores‐Romo, L., & Hernández‐Pando, R. (2004) · Immunology · doi:10.1046/j.1365-2567.2004.01904.x · Cited by 36
Dendritic cells in allergic airway inflammationThis article is one of a selection of papers published in the Special Issue on Recent Advances in Asthma Research.
Bharadwaj, A. S., Bewtra, A. K., & Agrawal, D. K. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y07-062 · Cited by 36
“The turnover rate of airway DCs is rapid with a half-life of less than 36 h, whereas that of peripheral lung DCs is approximately 10 days (Holt et al. 1994).”
Background
Interplay between alveolar epithelial and dendritic cells and Mycobacterium tuberculosis
Rodrigues, T. S., Conti, B. J., Fraga‐Silva, T. F. D. C., Almeida, F. B. D. R., & Bonato, V. L. D. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0520-112r · Cited by 34
Phenotype and distribution of dendritic cells in the porcine small intestinal and tracheal mucosa and their spatial relationship to epithelial cells
Bimczok, D., Post, A., Tschernig, T., et al. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0195-3 · Cited by 34
“Similar observations have previously been made in humans, rats and mice, with 400–800 of intraepithelial DC/ mm2 of epithelial surface (Holt et al. 1994; Tschernig et al. 2001; Schon-Hegrad et al. 1991).”
BackgroundResult
Allergen Recognition in the Origin of Asthma
Holt, P. G., Yabuhara, A., Prescott, S. L., Venaille, T. J., Macaubas, C., Holt, B. J., Björkstén, B., & Sly, P. D. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515334.ch3 · Cited by 34
Self-citation
The lymphatic vasculature in lung function and respiratory disease
Trivedi, A., & Reed, H. O. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1118583 · Cited by 34
Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation
Mincham, K. T., Scott, N. M., Lauzon‐Joset, J., Leffler, J., Larcombe, A. N., Stumbles, P. A., Robertson, S. A., Pasquali, C., Holt, P. G., & Strickland, D. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122631 · Cited by 32
Self-citation
Epithelial cells, the “switchboard” of respiratory immune defense responses: effects of air pollutants
Müller, L. L., & Jaspers, I. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13653 · Cited by 33
Dendritic Cell Trafficking and Function in Rare Lung Diseases
Liu, H., Jakubzick, C., Osterburg, A. R., Nelson, R. L., Gupta, N., McCormack, F. X., & Borchers, M. T. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0051ps · Cited by 32
“Under steady-state conditions, a limited number of DCs reside in lung tissue and patrol the environment, whereas circulating pre-DCs migrate into the lung at a constant rate to replenish the resident DC pool, as it turns over every 10–14 days (13, 36, 37).”
Background
Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma
Spears, M., McSharry, C. P., Donnelly, I., et al. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03692.x · Cited by 32
Dendritic cells in the lung: what is their relevance to asthma?
Semper, A. E., & Hartley, J. A. (1996) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1996.tb00568.x · Cited by 32
Low Sphingosine-1–Phosphate Impairs Lung Dendritic Cells in Cystic Fibrosis
Xu, Y., Krause, A., Limberis, M. P., Worgall, T. S., & Worgall, S. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0021oc · Cited by 31
“The half-life of a lung DC is only approximately 2 days (36).”
Background
Acute lung injury after allogeneic stem cell transplantation: From the clinic, to the bench and back again
Cooke, K. R. (2005) · Pediatric Transplantation · doi:10.1111/j.1399-3046.2005.00450.x · Cited by 31
“By contrast, lung parenchymal DCs were only reduced by 50% at day 3 and 60% by day 6 and declined at a rate that was intermediate between airway and epidermal DC populations (89).”
Background
Lung dendritic cells and the inflammatory response
Grayson, M. H. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61061-7 · Cited by 30
In Vivo Germination of Bacillus anthracis Spores During Murine Cutaneous Infection
Corre, J., Piris‐Giménez, A., Moya-Nilges, M., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis686 · Cited by 29
“cells [41], and germination has been demonstrated on abraded skin [27].”
Background
Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines
de Geus, E. D., Rebel, J. M. J., & Vervelde, L. (2012) · Veterinary Quarterly · doi:10.1080/01652176.2012.711956 · Cited by 29
“In the RT, tracheal DC have a rapid turnover rate (2–3 days), while interstitial DC are long lived (Holt et al. 1994; von Garnier et al. 2005).”
Background
Detection of Clonal Lymphoid Receptor Gene Rearrangements in Langerhans Cell Histiocytosis
Chen, W., Wang, J., Wang, E., et al. (2010) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3181e5341a · Cited by 29
“The origin of LCs from bone marrow has been confirmed and supported by recent studies on LCs in airway and vaginal mucosa as well.(23,26) Arceci(5) initially speculated LCs could be repopulated by circulating monocyte precursor cells, and this hypothesis was subsequently supported by data from Merad et al in 2002(33)…”
Result
The role of dendritic cells and regulatory T cells in the regulation of allergic asthma
Burchell, J. T., Strickland, D. H., & Stumbles, P. A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.06.015 · Cited by 29
“CD11c+MHCIIhi DC in the respiratory mucosa are known to exhibit a high rate of turnover (approximate half-life of 12 h) as antigen-bearing DC continuously migrate to the DLN and are replaced by de novo DC from the bone marrow (Holt et al., 1994; Lambrecht et al., 1998; von Garnier et al., 2005).”
Background
Early Onset Noninfectious Pulmonary Syndromes after Hematopoietic Cell Transplantation
Vusse, L. K. V., & Madtes, D. K. (2017) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.12.007 · Cited by 29
Chronic antagonism of Mig inhibits cellular infiltration and promotes survival of class II MHC disparate skin allografts
Kobayashi, H., Novick, A. C., Toma, H., & Fairchild, R. L. (2002) · Transplantation · doi:10.1097/00007890-200208150-00016 · Cited by 29
Effects of environmental tobacco smoke on the developing immune system of infant monkeys
Wang, L., Joad, J. P., Abel, K., Spinner, A., Smiley‐Jewell, S. M., Liu, H., & Pinkerton, K. E. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.03.028 · Cited by 29
Dendritic Cells and the Regulation of a Granulomatous Immune Response in the Lung
Iyonaga, K., McCarthy, K. M., & Schneeberger, E. E. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.6.4798 · Cited by 26
Progressor but not regressor skin tumours inhibit Langerhans’ cell migration from epidermis to local lymph nodes
Lucas, A., & Halliday (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00751.x · Cited by 26
Immunoregulatory mechanisms between epithelial clear cells and mononuclear phagocytes in the epididymis
Battistone, M. A., Elizagaray, M. L., Barrachina, F., Ottino, K., Mendelsohn, A. C., & Breton, S. (2023) · Andrology · doi:10.1111/andr.13509 · Cited by 25
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A., & Höpken, U. E. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008883117 · Cited by 22
The Nasal-associated Lymphoid Tissue of Adult Mice Acts as an Entry Site for the Mouse Mammary Tumor Retrovirus
Velin, D., Fotopoulos, G., Luthi, F., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.10.1871 · Cited by 25
“Brief Definitive Report mechanism, it might be possible that in the intestine, nasal, or lung cavities, MMTV infects or is taken up by dendritic cells associated with the epithelium (15, 16).”
Background
The Role of Nucleotide-Binding Oligomerization Domain–Like Receptors in Pulmonary Infection
Wiese, K. M., Coates, B. M., & Ridge, K. M. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0375tr · Cited by 25
“Once a pathogen is encountered, dendritic cells phagocytose it and carry the associated pathogenic antigens on their major histocompatibility complex molecules to the peripheral lymphoid organs to stimulate T lymphocytes (59).”
Background
Origin and steady-state turnover of major histocompatibility complex Class II-positive dendritic cells and resident-tissue macrophages in the iris of the rat eye
Steptoe, R. J., Holt, P. G., & McMenamin, P. G. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(96)00070-7 · Cited by 25
Self-citation

Authors: Holt, P. G., Haining, S., Nelson, D. J., & Sedgwick, J. D.
Affiliations: The Kids Research Institute Australia (AU)
Centenary Institute (AU)
ORCID: Holt, P G
Nelson, D J
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1994-07-01
Volume: 153
Issue: 1
Pages: 256-261
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.153.1.256
OpenAlex: W1675056235
Cited by: 347
References: 0
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 2 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 11 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 14
FWCI: 6.46
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: airway epithelium, radiation chimeras, Langerhans cells, mucosal immunity, X-ray irradiation
MeSH terms: Animals, Histocompatibility Antigens Class II, Dendritic Cells, Dexamethasone, Epithelial Cells, Langerhans Cells, Lung, Radiation Chimera, Trachea, X-Rays, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks