Cited by 348Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

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Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

Holt, P G, Haining, S, Nelson, D J, Sedgwick, J D·1994·The Journal of Immunology

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Abstract

Recent studies have identified a contiguous network of class II MHC-bearing dendritic cells (DC) in the airway epithelium of several species, including humans. This network seems comparable to the epidermal Langerhans cell population, comprising up to 700 DC per mm2 of airway epithelium. Moreover, it accounts for virtually all local immunostaining for class II MHC, suggesting an important role in surveillance for inhaled Ag. This study examines the turnover of these airway DC using a radiation chimera model that uses congenic rats expressing different allotypic variants of CD45, detectable via mAbs. Steady-state bone marrow renewal of the airway DC population (which is continuously depleted by migration of mature cells to draining lymph nodes) was interrupted via x-irradiation or high-dose dexamethasone, after which the resident population declined by 85% over the ensuing 72 h. After transplantation with congenic bone marrow and an initial lag period for graft establishment, the airway DC population was rapidly restored to preirradiation levels. These findings indicate a half-life of < or = 2 days for airway epithelial DC. In contrast, epidermal Langerhans cell half-life was > or = 15 days. The only comparable (short) half-life previously reported for a peripheral tissue DC population, is that derived from the gut wall. This indicates that rapidly turning over DC populations are a unique feature of the major "mucosal" organ systems, which is consistent with these DC playing an important role in surveillance of mucosal tissues for incoming Ag.

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Crossref · 10.4049/jimmunol.153.1.256

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Background

Authors: Holt, P. G., Haining, S., Nelson, D. J., & Sedgwick, J. D.
Affiliations: The Kids Research Institute Australia (AU)
Centenary Institute (AU)
ORCID: Holt, P G
Nelson, D J
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1994-07-01
Volume: 153
Issue: 1
Pages: 256-261
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.153.1.256
OpenAlex: W1675056235
Cited by: 347
References: 0
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 2 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 11 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 14
FWCI: 6.46
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: airway epithelium, radiation chimeras, Langerhans cells, mucosal immunity, X-ray irradiation
MeSH terms: Animals, Histocompatibility Antigens Class II, Dendritic Cells, Dexamethasone, Epithelial Cells, Langerhans Cells, Lung, Radiation Chimera, Trachea, X-Rays, Rats

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Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

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