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The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation.
Abstract
The discovery that the high affinity IgE receptor (Fc epsilon RI) is expressed on APCs of patients with atopic diseases raised the possibility that the functional importance of Fc epsilon RI in the pathogenesis of atopy may extend beyond its role in type I allergic reactions. Here we show that, following removal of in vivo-bound IgE by lactic acid treatment, targeting of allergens to monocytes by Ag-specific IgE critically depends on Fc epsilon RI expression. Even more importantly, lactic acid-treated, monocyte-enriched PBMCs present allergen to T cells 100- to 1000-fold more effectively if the allergen has been targeted to Fc epsilon RI on these cells via allergen-specific IgE. This mechanism may critically lower the atopic individual's threshold to mount allergen-specific T cell responses capable of promoting IgE production and delayed-type hypersensitivity reactions.
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Citations
Cited by
Daëron, M. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.203 · Cited by 1,227
THE HIGH-AFFINITY I g E RECEPTOR (FcεRI): From Physiology to Pathology
Kinet, J.-P. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.931 · Cited by 968
Self-citationLymph node trafficking and antigen presentation by endobronchial eosinophils
Shi, H.-Z., Humbles, A., Gerard, C., Jin, Z., & Weller, P. F. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8945 · Cited by 326
Heil, P. M., Maurer, D., Klein, B., Hultsch, T., & Stingl, G. (2010) · JDDG: Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2010.07497.x · Cited by 197
Self-citationNovak, N., Valenta, R., Bohle, B., Laffer, S., Haberstok, J., Kraft, S., & Bieber, T. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.02.005 · Cited by 189
Metadata
- Authors
- Maurer, D., Ebner, C., Reininger, B., Fiebiger, E., Kraft, D., Kinet, J. P., & Stingl, G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-06
- Volume
- 154
- Issue
- 12
- Pages
- 6285-6290
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1900907547
- Cited by
- 348
- References
- 0
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. https://app.cochat.ai/papers/10.4049/jimmunol.154.12.6285
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- Maurer, D., Ebner, C., Reininger, B., Fiebiger, E., Kraft, D., Kinet, J. P., & Stingl, G. (1995). The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.154.12.6285
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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