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Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis
Abstract
FAS/Apo-1 (CD95) is an apoptosis-signaling cell surface receptor belonging to the TNF receptor family. Tumor cells resistant to Fas-mediated apoptosis have been described, but to date, the mechanisms responsible for this resistance are not well understood. We found that a series of apoptosis-resistant clones from human HUT78 lymphoma cells express a splicing variant coding for a truncated Fas molecule that lacks the intracellular death-signaling domain. The mutation responsible for the FasExo8Del expression was identified as a deletion-insertion in the intron 7/exon 8 region of the Fas gene. Moreover this mutation affects the phenotype in a dominant negative fashion, i.e., even in the presence of the normal receptor.
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Citations
Cited by
Death and anti-death: tumour resistance to apoptosis
Igney, F. H., & Krammer, P. H. (2002) · Nature Reviews Cancer · doi:10.1038/nrc776 · Cited by 2,075
Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis
De Maria, R., Lenti, L., Malisan, F., d'Agostino, F., Tomassini, B., Zeuner, A., Rippo, M. R., & Testi, R. (1997) · Science · doi:10.1126/science.277.5332.1652 · Cited by 423
Self-citationPrasad, N. K. A., Papoff, G., Zeuner, A., Bonnin, E., Kazatchkine, M. D., Ruberti, G., & Kaveri, S. V. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3781 · Cited by 279
Self-citationFas ligand/Fas system in the brain: regulator of immune and apoptotic responses
Choi, C., & Benveniste, E. N. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2003.08.007 · Cited by 270
The Fas counterattack: Cancer as a site of immune privilege
O’Connell, J., Bennett, M. W., O’Sullivan, G. C., Collins, J. K., & Shanahan, F. (1999) · Immunology Today · doi:10.1016/s0167-5699(98)01382-6 · Cited by 232
Metadata
- Authors
- Cascino, I., Papoff, G., De Maria, R., Testi, R., & Ruberti, G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-01-01
- Volume
- 156
- Issue
- 1
- Pages
- 13-17
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1772617136
- Cited by
- 169
- References
- 0
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis. https://app.cochat.ai/papers/10.4049/jimmunol.156.1.13
- The paper
- Cascino, I., Papoff, G., De Maria, R., Testi, R., & Ruberti, G. (1996). Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.156.1.13
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
