Cited by 480Stress Responses and CortisolAdrenal Hormones and DisordersCancer, Stress, Anesthesia, and Immune Response

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Stress-induced changes in blood leukocyte distribution. Role of adrenal steroid hormones

Dhabhar, F S, Miller, A H, McEwen, B S, Spencer, R L·1996·The Journal of Immunology

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Abstract

The numbers and proportions of leukocytes in the blood provide an important representation of the state of activation of the immune system, and of the pattern of distribution of immune cells in the body. We have shown previously that acute stress induces large, rapid, and reversible changes in the distribution of peripheral blood leukocyte subpopulations in the rat. The studies described here specifically investigate the role played by adrenal steroid hormones in mediating stress-induced changes in blood leukocyte distribution. Since adrenal steroids act at two distinct receptor subtypes that show a heterogeneity of expression in immune cells and tissues, the role played by each subtype in mediating changes in leukocyte distribution is also investigated. Cyanoketone, a corticosterone (CORT) synthesis inhibitor, significantly reduced the decrease in lymphocyte numbers observed during stress and significantly enhanced the increase in neutrophil numbers observed after the cessation of stress. Acute administration of aldosterone (a specific type I adrenal steroid receptor agonist) to adrenalectomized animals did not have a significant effect on blood leukocyte numbers. In contrast, acute administration of CORT (the endogenous type I and type II receptor agonist), or RU28362 (a specific type II receptor agonist), to adrenalectomized animals produced changes in leukocyte distribution that were similar to those observed in intact animals during stress. These results suggest that CORT, acting at the type II adrenal steroid receptor, is a major mediator of the stress-induced changes in blood lymphocyte and monocyte distribution.

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Crossref · 10.4049/jimmunol.157.4.1638

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“Glucocorticoids are naturally increased at the end of pregnancy for fetal brain and lung development [32] and act as major mediators of leukocyte distribution [33].”
Background
EFFECT OF OXIDATIVE STRESS ON LIPID PROFILE AND BLOOD PARAMETERS TO A SAMPLE OF STUDENTS AT UNIVERSITY OF ZAKHO DURING EXAMES
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“Finally, resilience is a condition between eustress and distress in which physiologic systems allow host survival for long periods of time under exhausting demands.([9]) The activation of the hypothalamic pituitary adrenal axis (HPAA) and the sympathetic nervous system (SNS) in response to various types of stressors i…”
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Glucocorticoids
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“As noted by Sopinka et al. (2016), stress conditions can trigger an increase in the number of total WBC (A. K. Davis et al., 2008; Dhabhar et al., 1996).”
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“There 35348510. m (F.H. Wattoo). y. Production and hosting by Saud University. lsevier are evidences in the literature that stress may reduce the effectiveness of human immune system and increase the risk of infections and diseases (Dhabhar et al., 1996).”
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“This effect is mediated by acute elevation of glucocorticoids (Dhabhar et al., 1996) and is sensible from an evolutionary perspective as acute stressors would often have been associated with wounding and potential infection; thus, it would not be adaptive for acute increases in glucocorticoids to…”
Background
Dietary Fiber Source and Length of Feeding Partitions Differentially Affected Behavior, Immune Status, and Productivity of Group-Housed Dry Sows
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Background
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“Simultaneous decrease in lymphocytes and increase in neutrophils, leading to an increase in the neutrophil: lymphocyte ratio occurs under stressful conditions (Dhabhar et al., 1996).”
Background
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Background
Regulation of the Injury-Immune Response in the Central Nervous System
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Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation
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Short communication: Reliability testing and applied use of a measure of neutrophil activation in stress research
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Rat Basophilic Leukemia Cells (RBL-2H3) Generate Prostaglandin D 2 (PGD 2 ) after Regulated upon Activation, Normal T-cell Expressed and Secreted (RANTES) activation
Castellani, M. L., Petrarca, C., Frydas, S., et al. (2006) · The International Journal of Biological Markers · doi:10.1177/172460080602100403 · Cited by 2
“Cytokines are secreted under stress, and it has been shown that acute stress induces trafficking of leukocytes and augments immune responses (33-35).”
Background

Authors: Dhabhar, F. S., Miller, A. H., McEwen, B. S., & Spencer, R. L.
Affiliations: Rockefeller University (US)
University of Colorado Boulder (US)
ORCID: Dhabhar, F S
Miller, A H
Spencer, R L
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1996-08
Volume: 157
Issue: 4
Pages: 1638-1644
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.157.4.1638
OpenAlex: W2127386463
Cited by: 480
References: 0
Citations by year: 2026: 4 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 13 · 2021: 15 · 2020: 13 · 2019: 17 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 21 · 2014: 21 · 2013: 13 · 2012: 23
FWCI: 5.48
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Keywords: acute stress, adrenal steroids, corticosterone, type II glucocorticoid receptor, aldosterone, lymphocyte distribution, adrenalectomy, cyanoketone, immune activation
MeSH terms: Adrenal Cortex, Adrenal Cortex Hormones, Adrenalectomy, Aldosterone, Animals, Corticosterone, Cyanoketone, Enzyme Inhibitors, Leukocyte Count, Male, Receptors, Glucocorticoid, Restraint, Physical, Stress, Psychological, 3-Hydroxysteroid Dehydrogenases, Lymphocyte Subsets, Rats, Sprague-Dawley, Receptors, Mineralocorticoid, Rats

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Stress-induced changes in blood leukocyte distribution. Role of adrenal steroid hormones

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