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CD8+ T cells clear influenza virus by perforin or Fas-dependent processes
Abstract
Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or perforin (P-/-). Virus-immune P+/+ and P-/- CD8+ T cells can thus function in, respectively, a Fas-/- or Fas+/+ lung environment. The obvious question is whether the P-/- CD8+ set is effective in Fas-/- mice, a conclusion that would tend to favor cytokine secretion as the mode of virus clearance. Short term chimeras were made with P-/- bone marrow, P+/+ or P-/- T cells, and Fas+/+ or Fas-/- irradiated recipients. While the P+/+ CD8+ population cleared the virus from Fas+/+ and Fas-/- respiratory epithelium, the P-/- effectors were operational only if there was the potential for Fas to be expressed on radiation-resistant lung cells. Target cell destruction mediated via the Fas or perforin pathways is clearly the primary mechanism used by CD8+ T cells to terminate this viral pneumonia.
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Citations
Cited by
Lymphocyte-Mediated Cytotoxicity
Russell, J. H., & Ley, T. J. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100201.131730 · Cited by 1,122
Wilkinson, T. M., Li, C. K. F., Chui, C. S. C., Huang, A. K. Y., Perkins, M., Liebner, J. C., Lambkin-Williams, R., Gilbert, A., Oxford, J., Nicholas, B., et al. (2012) · Nature Medicine · doi:10.1038/nm.2612 · Cited by 974
Jordan, M. B., Hildeman, D., Kappler, J., & Marrack, P. (2004) · Blood · doi:10.1182/blood-2003-10-3413 · Cited by 712
Cell-mediated Protection in Influenza Infection
Thomas, P. G., Keating, R., Hulse-Post, D. J., & Doherty, P. C. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1201.051237 · Cited by 466
Self-citationThe CD8 T Cell Response to Respiratory Virus Infections
Schmidt, M. E., & Varga, S. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00678 · Cited by 371
Metadata
- Authors
- Topham, D. J., Tripp, R. A., & Doherty, P. C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-12-01
- Volume
- 159
- Issue
- 11
- Pages
- 5197-5200
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1529149321
- Cited by
- 486
- References
- 0
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Topham, D. J., Tripp, R. A., & Doherty, P. C. (1997). CD8+ T cells clear influenza virus by perforin or Fas-dependent processes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.159.11.5197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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