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IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis
Abstract
To examine the role of the Th2-type response during schistosomiasis mansoni we compared disease progression in wild type (wt), and Th2-response deficient IL-4(-/-) mice. Whereas wt C57BL/6 mice tolerate infection and develop chronic disease, IL-4(-/-) C57BL/6 animals are highly susceptible, exhibiting severe acute cachexia followed by death. Data point toward morbidity in the IL-4(-/-) C57BL/6 mice being mediated by TNF-alpha, possibly through the uncontrolled production of nitric oxide in target organs such as the ileum. We propose that IL-4 prevents severe disease during schistosomiasis by regulating macrophage activation.
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Citations
Cited by
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 958
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816
Self-citationHelminth infections and host immune regulation
McSorley, H. J., & Maizels, R. M. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.05040-11 · Cited by 499
Hoffmann, K. F., Cheever, A. W., & Wynn, T. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6406 · Cited by 473
Self-citationFallon, P. G., Richardson, E. J., McKenzie, G. J., & McKenzie, A. N. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2585 · Cited by 403
Metadata
- Authors
- Brunet, L. R., Finkelman, F. D., Cheever, A. W., Kopf, M. A., & Pearce, E. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-07
- Volume
- 159
- Issue
- 2
- Pages
- 777-785
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1906468352
- Cited by
- 271
- References
- 0
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis. https://app.cochat.ai/papers/10.4049/jimmunol.159.2.777
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- Brunet, L. R., Finkelman, F. D., Cheever, A. W., Kopf, M. A., & Pearce, E. J. (1997). IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.159.2.777
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
