Cited by 250Food Allergy and Anaphylaxis ResearchAllergic Rhinitis and SensitizationDrug-Induced Adverse Reactions

The DOI matches its Crossref record.

Allergenic properties of ovomucoid in man

Cooke, S K, Sampson, H A·1997·The Journal of Immunology

DOI 10.4049/jimmunol.159.4.2026

Open this paper in CoChat — free account

Abstract

Ovomucoid, the dominant allergen in hen’s egg, is a highly glycosylated protein comprising 186 amino acids arranged in three tandem domains (Gal d 1.1, 1.2, and 1.3). The purpose of this study was to evaluate the allergenic properties of ovomucoid. The three ovomucoid domains were isolated and evaluated with sera from egg allergic patients to determine B cell domain specificity, B cell epitopes, and the relative importance of linear and conformational structures and carbohydrate chains to B cell epitopes. Peripheral blood T cells from egg allergic patients were used to evaluate T-dominant domains and reactivity to reduced and oxidized ovomucoid. There was significantly more IgE activity to the second ovomucoid domain (median percentage of ovomucoid-specific IgE: Gal d 1.2, 40%; Gal d 1.1, 23%; Gal d 1.3, 26%). Quantities of patient IgG Ab were comparable for all three domains. Five IgE and seven IgG binding regions were identified. IgE Ab binding to reduced ovomucoid and IgG binding to oxidized ovomucoid were significantly reduced compared with that to native ovomucoid (28 and 69%, respectively). Peripheral blood T cells of 21 of 33 patients reacted to Gal d 1.3, 18 of 33 reacted to Gal d 1.2, and 18 of 33 reacted to Gal d 1.1. T cell proliferation in vitro in response to reduced and oxidized ovomucoid were significantly greater than that in response to the native protein. These results indicate a dichotomy between T and B cell domain dominance, and the presence of both unique and common IgE and IgG epitopes. Furthermore, the results suggest that conformational B cell epitopes play a more significant role in ovomucoid allergenicity than previously appreciated, and that carbohydrate moieties have a minor effect on allergenicity.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.159.4.2026

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Still being checked.

Sorted by citations

Update on food allergy.
Sampson, H. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.014 · Cited by 844
Self-citation
EAACI Molecular Allergology User's Guide
Matricardi, P. M., Kleine‐Tebbe, J., Hoffmann, H. J., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R. C., Agache, I., Asero, R., Ballmer‐Weber, B., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12563 · Cited by 932
Food allergy. Part 1: Immunopathogenesis and clinical disorders
Sampson, H. A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70411-2 · Cited by 828
Self-citation
Immunologic changes in children with egg allergy ingesting extensively heated egg
Lemon-Mulé, H., Sampson, H. A., Sicherer, S. H., Shreffler, W. G., Noone, S. A., & Nowak-Wegrzyn, A. H. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.09.007 · Cited by 476
Self-citation
Dietary baked milk accelerates the resolution of cow’s milk allergy in children
Kim, J. S., Nowak-Wegrzyn, A. H., Sicherer, S. H., Noone, S. A., Moshier, E. L., & Sampson, H. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.036 · Cited by 424
Self-citation
Microarray immunoassay: Association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes
Shreffler, W. G., Beyer, K., Chu, T.-H. T., Burks, A. W., & Sampson, H. A. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.588 · Cited by 349
Self-citation
EAACI Molecular Allergology User's Guide 2.0
Dramburg, S., Hilger, C., Santos, A. F., Vecillas, L. D. L., Aalberse, R. C., Acevedo, N., Aglas, L., Altmann, F., Arruda, L. K., Asero, R., et al. (2023) · Pediatric Allergy and Immunology · doi:10.1111/pai.13854 · Cited by 342
Identification of IgE- and IgG-binding epitopes on αs1-casein: Differences in patients with persistent and transient cow's milk allergy
Chatchatee, P., Järvinen, K. M., Bardina, L., Beyer, K., & Sampson, H. A. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112372 · Cited by 298
Self-citation
Rare, medium, or well done? The effect of heating and food matrix on food protein allergenicity
Nowak-Wegrzyn, A. H., & Fiocchi, A. G. (2009) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32832b88e7 · Cited by 263
Common food allergens and their IgE-binding epitopes.
Matsuo, H., Yokooji, T., & Taogoshi, T. (2015) · Allergology International · doi:10.1016/j.alit.2015.06.009 · Cited by 235
Food allergy: a practice parameter.
Chapman, J., Bernstein, I., Lee, R. E., Oppenheimer, J., Nicklas, R., Portnoy, J., Sicherer, S., Schuller, D., Spector, S., Khan, D. A., et al. (2006) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)60926-x · Cited by 269
Food allergy
Sicherer, S. H. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09831-8 · Cited by 262
Future therapies for food allergies
Nowak-Wegrzyn, A. H., & Sampson, H. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.1098 · Cited by 256
Self-citation
Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy
Ando, H., Movérare, R., Kondo, Y., Tsuge, I., Tanaka, A., Borres, M. P., & Urisu, A. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.06.016 · Cited by 253
Resolution of peanut allergy: case-control studyScience commentary: Why do some children grow out of peanut allergy?
Hourihane, J. O., Berger, A., Roberts, S. A., & Warner, J. O. (1998) · BMJ · doi:10.1136/bmj.316.7140.1271 · Cited by 247
Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy
Vila, L., Beyer, K., Järvinen, K. M., Chatchatee, P., Bardina, L., & Sampson, H. A. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01218.x · Cited by 240
Self-citation
Scientific Opinion on the evaluation of allergenic foods and food ingredients for labelling purposes
EFSA Panel on Dietetic Products, N. A. A. (. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3894 · Cited by 254
Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy
Järvinen, K. ‐., Beyer, K., Vila, L., Bardina, L., Mishoe, M., & Sampson, H. A. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01332.x · Cited by 267
Self-citation
Structural, Biological, and Evolutionary Relationships of Plant Food Allergens Sensitizing via the Gastrointestinal Tract
Mills, E. N. C., Jenkins, J., Alcocer, M., & Shewry, P. (2004) · Critical reviews in food science and nutrition · doi:10.1080/10408690490489224 · Cited by 211
Identification of IgE and IgG binding epitopes on β‐ and κ‐casein in cow's milk allergic patients
Chatchatee, P., Järvinen, K. M., Bardina, L., Vila, L., Beyer, K., & Sampson, H. A. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01167.x · Cited by 209
Self-citation
Recent advances in the understanding of egg allergens: basic, industrial, and clinical perspectives
Mine, Y., & Yang, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8001153 · Cited by 196
Current understanding of egg allergy
Caubet, J., & Wang, J. (2011) · The Pediatric clinics of North America · doi:10.1016/j.pcl.2011.02.014 · Cited by 175
Effect of heat treatment on milk and egg proteins allergenicity
Bloom, K. A., Huang, F., Bencharitiwong, R., Bardina, L., Ross, A., Sampson, H. A., & Nowak-Wegrzyn, A. H. (2014) · Pediatric Allergy and Immunology · doi:10.1111/pai.12283 · Cited by 186
Self-citation
Identification of IgE‐binding epitopes on gliadins for patients with food allergy to wheat
Battais, F., Mothes, T., Moneret‐Vautrin, D. A., Pineau, F., Kanny, G., Popineau, Y., Bodinier, M., & Denery-Papini, S. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00795.x · Cited by 178
Adverse reactions to foods.
Nowak-Węgrzyn, A., & Sampson, H. (2006) · The Medical clinics of North America · doi:10.1016/j.mcna.2005.08.012 · Cited by 148
Self-citation
Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age
Ayuso, R., Sánchez-García, S., Lin, J., Fu, Z., Ibáñez, M. D., Carrillo, T., Blanco, C., Goldis, M., Bardina, L., Sastre, J., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.03.010 · Cited by 159
Self-citation
Measurement of peptide-specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts
Beyer, K., Ellman-Grunther, L., Järvinen, K. M., Wood, R. A., Hourihane, J. O., & Sampson, H. A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1621 · Cited by 149
Self-citation
Effect of Processing Technologies on the Allergenicity of Food Products
Jiménez‐Saiz, R., Benedé, S., Molina, E., & López‐Expósito, I. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.736435 · Cited by 132
Mechanisms underlying differential food allergy response to heated egg
Martos, G., Lopez-Exposito, I., Bencharitiwong, R., Berin, M. C., & Nowak-Węgrzyn, A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.057 · Cited by 145
Clinical Relevance of Cross-Reactivity in Food Allergy
Cox, A. L., Eigenmann, P., & Sicherer, S. H. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.09.030 · Cited by 127
Human Immunoglobulin E (IgE) Binding to Heated and Glycated Ovalbumin and Ovomucoid before and after in Vitro Digestion
Jiménez‐Saiz, R., Belloque, J., Molina, E., & López‐Fandiño, R. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2014638 · Cited by 127
Significance of ovomucoid- and ovalbumin-specific IgE/IgG4 ratios in egg allergy
Caubet, J., Bencharitiwong, R., Moshier, E. L., Godbold, J., Sampson, H. A., & Nowak-Wegrzyn, A. H. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.053 · Cited by 121
Self-citation
Food allergy: Past, present and future
Sampson, H. A. (2016) · Allergology International · doi:10.1016/j.alit.2016.08.006 · Cited by 122
Self-citation
Anaphylactic reactions to raw eggs after negative challenges with cooked eggs
Eigenmann, P. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.104255 · Cited by 113
Approaches to establish thresholds for major food allergens and for gluten in food.
Buchanan, R., Dennis, S., Gendel, S., Acheson, D., Assimon, S. A., Beru, N., Bolger, P., Carlson, D., Carvajal, R., Copp, C., et al. (2008) · Journal of Food Protection · doi:10.4315/0362-028x-71.5.1043 · Cited by 100
The role of immunoglobulin E-binding epitopes in the characterization of food allergy
Lin, J., & Sampson, H. A. (2009) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32832d05ba · Cited by 103
Self-citation
Ovomucoid (Gal d 1) specific IgE detected by microarray system predict tolerability to boiled hen's egg and an increased risk to progress to multiple environmental allergen sensitisation
Alessandri, C., Zennaro, D., Scala, E., Ferrara, R., Bernardi, M. L., Santoro, M., Palazzo, P., & Mari, A. (2012) · Clinical and Experimental Allergy · doi:10.1111/j.1365-2222.2011.03915.x · Cited by 65
State of the art and new horizons in the diagnosis and management of egg allergy
Benhamou, A., Caubet, J., Eigenmann, P., Grzyn, A. N., Marcos, C., Reche, M., & Urisu, A. (2010) · Allergy. European Journal of Allergy and Clinical Immunology · doi:10.1111/j.1398-9995.2009.02251.x · Cited by 100
Food allergen protein families and their structural characteristics and application in component-resolved diagnosis: new data from the EuroPrevall project
Hoffmann‐Sommergruber, K., & Mills, E. N. C. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2953-z · Cited by 94
Performance of a component‐based allergen‐microarray in the diagnosis of cow's milk and hen's egg allergy
D’Urbano, L. E., Pellegrino, K., Artesani, M. C., Donnanno, S., Lucianò, R., Riccardi, C., Tozzi, A. E., Ravà, L., Benedetti, F. D., & Cavagni, G. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03568.x · Cited by 94
Food allergies: prevalence, molecular characterization, and treatment/prevention strategies.
Lee, L. A., & Burks, A. (2006) · Annual review of nutrition · doi:10.1146/annurev.nutr.26.061505.111211 · Cited by 86
Identification of two pistachio allergens, Pis v 1 and Pis v 2, belonging to the 2S albumin and 11S globulin family
Ahn, K., Bardina, L., Grishina, G. T., Beyer, K., & Sampson, H. A. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03259.x · Cited by 89
Self-citation
Clinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87
Tolerance to cooked egg in an egg allergic population
Roches, A. D., Nguyen, M., Paradis, L. P., Primeau, M., & Singer, S. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01134.x · Cited by 86
Decrease in Antigenic and Allergenic Potentials of Ovomucoid by Heating in the Presence of Wheat Flour: Dependence on Wheat Variety and Intermolecular Disulfide Bridges
Kato, Y., Eri, O., & Matsuda, T. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0102766 · Cited by 83
The Influence of the Time and Temperature of Heat Treatment on the Allergenicity of Egg White Proteins
Shin, M., Han, Y., & Ahn, K. (2013) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2013.5.2.96 · Cited by 82
Egg proteins as allergens and the effects of the food matrix and processing
Benedé, S., López‐Expósito, I., Molina, E., & López‐Fandiño, R. (2014) · Food & Function · doi:10.1039/c4fo01104j · Cited by 83
Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy
Kim, E., Perry, T. T., Wood, R. A., Leung, D. Y. M., Berin, M. C., Burks, A. W., Cho, C. B., Jones, S. M., Scurlock, A. M., Sicherer, S. H., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.040 · Cited by 78
Self-citation
The Impact of Baked Egg and Baked Milk Diets on IgE- and Non-IgE-Mediated Allergy
Upton, J. E. M., & Nowak-Wegrzyn, A. H. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8669-0 · Cited by 77
Oral Food Challenge
Calvani, M., Bianchi, A., Reginelli, C., Peresso, M., & Testa, A. (2019) · Medicina · doi:10.3390/medicina55100651 · Cited by 84
Novel B and T cell epitopes of chicken ovomucoid (Gal d 1) induce T cell secretion of IL‐6, IL‐13, and IFN‐γ
Holen, E., Bolann, B., & Elsayed, S. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01102.x · Cited by 76
Molecular diagnosis of egg allergy
Caubet, J., Kondo, Y., Urisu, A., & Nowak-Wegrzyn, A. H. (2011) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3283464d1b · Cited by 75
Cellular immune responses to ovalbumin and house dust mite in egg‐allergic children
Ng, T. ‐., Holt, P. G., & Prescott, S. L. (2002) · Allergy · doi:10.1034/j.1398-9995.2002.1o3369.x · Cited by 71
Identification and Fine Mapping of IgG and IgE Epitopes in Ovomucoid
Mine, Y., & Wei Zhang, J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6725 · Cited by 87
Food processing: effects on allergenicity
Maleki, S. J. (2004) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200406000-00018 · Cited by 69
Novel Bead-Based Epitope Assay is a sensitive and reliable tool for profiling epitope-specific antibody repertoire in food allergy
Suprun, M., Getts, R. C., Raghunathan, R. R., Grishina, G. T., Witmer, M. V., Giménez, G., Sampson, H. A., & Suárez‐Fariñas, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-54868-7 · Cited by 69
Self-citation
Optimizing the Diagnosis of Food Allergy
Kattan, J. D., & Sicherer, S. H. (2014) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2014.09.009 · Cited by 70
Bringing the Next Generation of Food Allergy Diagnostics Into the Clinic
Santos, A. F., Kulis, M. D., & Sampson, H. A. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.09.009 · Cited by 66
Self-citation
Hen's Egg Allergy
Urisu, A., Kondo, Y., & Tsuge, I. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000375416 · Cited by 64
IgE Food Sensitization in Infants with Eczema Attending a Dermatology Department
Hill, D. J., Heine, R. G., Hosking, C. S., Brown, J. V. E., Thiele, L., Allen, K. J., Su, J. C., Varigos, G., & Carlin, J. B. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.04.070 · Cited by 64
Wheat grain allergies: an update on wheat allergens.
Battais, F., Richard, C., Jacquenet, S., Denery-Papini, S., & Moneret‐Vautrin, D. A. (2008) · PubMed · Cited by 63
Biologically Active Hen Egg Components in Human Health and Disease
Mine, Y., & Kovacs-Nolan, J. (2004) · The Journal of Poultry Science · doi:10.2141/jpsa.41.1 · Cited by 64
IGE-MEDIATED FOOD ALLERGY – EXTENSIVE REVIEW OF THE LITERATURE
Ebo, D., & Stevens, W. J. (2001) · Acta Clinica Belgica · doi:10.1179/acb.2001.035 · Cited by 71
Recent advances in component resolved diagnosis in food allergy
Borres, M. P., Maruyama, N., Sato, S., & Ebisawa, M. (2016) · Allergology International · doi:10.1016/j.alit.2016.07.002 · Cited by 58
Is it possible to make a diagnosis of raw, heated, and baked egg allergy in children using cutoffs? A systematic review
Calvani, M., Arasi, S., Bianchi, A., Caimmi, D. P., Cuomo, B., Dondi, A., Indirli, G. C., Grutta, S. L., Panetta, V., & Verga, M. C. (2015) · Pediatric Allergy and Immunology · doi:10.1111/pai.12432 · Cited by 58
Egg-specific IgE and basophil activation but not egg-specific T-cell counts correlate with phenotypes of clinical egg allergy
Berin, M. C., Grishin, A. V., Masilamani, M., Leung, D. Y. M., Sicherer, S. H., Jones, S. M., Burks, A. W., Henning, A. K., Dawson, P. M., Grabowska, J. A., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.01.044 · Cited by 53
Self-citation
Food-induced anaphylaxis
Järvinen, K. (2011) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32834694d8 · Cited by 32
Egg allergy in childhood: an update
Tey, D., & Heine, R. (2009) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32832b1f00 · Cited by 63
Specific immunoglobulin E responses in ZAP‐70‐deficient patients are mediated by Syk‐dependent T‐cell receptor signalling
Toyabe, S., Watanabe, A., Harada, W., Karasawa, T., & Uchiyama, M. (2001) · Immunology · doi:10.1046/j.1365-2567.2001.01246.x · Cited by 49
Future Approaches to Food Allergy
Nowak-Wegrzyn, A. H. (2003) · PEDIATRICS · doi:10.1542/peds.111.s3.1672 · Cited by 49
Phenotypes and endotypes of food allergy: A path to better understanding the pathogenesis and prognosis of food allergy
Baker, M. G., & Sampson, H. A. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.01.027 · Cited by 48
Self-citation
Clinical Significance of IgE–Binding Activity to Enzymatic Digests of Ovomucoid in the Diagnosis and the Prediction of the Outgrowing of Egg White Hypersensitivity
Urisu, A., Yamada, K., Tokuda, R., Ando, H., Wada, E., Kondo, Y., & Morita, Y. (1999) · International Archives of Allergy and Immunology · doi:10.1159/000024267 · Cited by 48
Kinetic Analysis of Pepsin Digestion of Chicken Egg White Ovomucoid and Allergenic Potential of Pepsin Fragments
Takagi, K., Teshima, R., Okunuki, H., Itoh, S., Kawasaki, N., Kawanishi, T., Hayakawa, T., Kohno, Y., Urisu, A., & Sawada, J.-I. (2005) · International Archives of Allergy and Immunology · doi:10.1159/000082581 · Cited by 55
Oral immunotherapy for food allergy: mechanisms and role in management
Nowak-Wegrzyn, A. H., & Albin, S. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12382 · Cited by 47
Utility of Component-Resolved Diagnostics in Food Allergy
Tuano, K. S., & Davis, C. M. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0534-0 · Cited by 49
T lymphocytes in food allergy: Overview of an intricate network of circulating and organ‐resident cells
Eigenmann, P. (2002) · Pediatric Allergy and Immunology · doi:10.1034/j.1399-3038.2002.01015.x · Cited by 47
The Influence of the Presence of Wheat Flour on the Antigenic Activities of Egg White Proteins
Shin, M., Lee, J., Ahn, K., Lee, S. I., & Han, Y. (2012) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2013.5.1.42 · Cited by 45
Effect of 4-hydroxy-2-nonenal treatment on the IgE binding capacity and structure of shrimp (Metapenaeus ensis) tropomyosin
Lv, L., Lin, H., Li, Z., Yuan, F., Gao, Q., & Ma, J. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.152 · Cited by 45
Mapping of the IgE and IgG4 Sequential Epitopes of Ovomucoid with a Peptide Microarray Immunoassay
Martínez-Botas, J., Cerecedo, I., Zamora, J., Vlaicu, C., Dieguez, M. C., Gómez-Coronado, D., de Dios, V., Terrados, S., & de la Hoz, B. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000343040 · Cited by 48
Identification and characterization of linear B-cell epitopes of β-globulin, a major allergen of sesame seeds
Wolff, N., Yannai, S., Karin, N., Levy, Y., Reifen, R. M., Dalal, I., & Cogan, U. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.07.038 · Cited by 44
Effect of Heat Treatment on the Quantitative Detection of Egg Protein Residues by Commercial Enzyme-Linked Immunosorbent Assay Test Kits
Fu, T., Maks, N. D., & Banaszewski, K. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903536z · Cited by 43
Extensively heated milk and egg as oral immunotherapy
Huang, F., & Nowak-Wegrzyn, A. H. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3283535bc3 · Cited by 43
Peptic digestibility of raw and heat-coagulated hen's egg white proteins at acidic pH range
Yoshino, K., Sakai, K., Mizuha, Y., Shimizuike, A., & Yamamoto, S. (2004) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480412331350173 · Cited by 43
Egg allergy: An update
Tan, J., & Joshi, P. (2013) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.12408 · Cited by 40
The Natural Course of Immediate-Type Cow’s Milk and Egg Allergies in Children
Kim, M., Lee, J. Y., Yang, H.-K., Won, H. J., Kim, K., Kim, J., & Ahn, K. (2019) · International Archives of Allergy and Immunology · doi:10.1159/000503749 · Cited by 40
T-Cell Epitopes of Food Allergens
Bohle, B. (2006) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:30:2:97 · Cited by 40
Recent Advances in Electrochemical Sensing Strategies for Food Allergen Detection
Curulli, A. (2022) · Biosensors · doi:10.3390/bios12070503 · Cited by 39
Fast amperometric immunoplatform for ovomucoid traces determination in fresh and baked foods
Benedé, S., Montiel, V. R., Povedano, E., Villalba, M., Mata, L., Galán‐Malo, P., Torrente-Rodríguez, R. M., Vargas, E., Reviejo, Á. J., Campuzano, S., et al. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.03.075 · Cited by 39
Avian Egg: A Multifaceted Biomaterial for Tissue Engineering
Mahdavi, S., Amirsadeghi, A., Jafari, A., Niknezhad, S. V., & Bencherif, S. A. (2021) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.1c03085 · Cited by 39
Epitope mapping and the effects of various factors on the immunoreactivity of main allergens in egg white
Gazme, B., Rezaei, K., & Udenigwe, C. C. (2021) · Food & Function · doi:10.1039/d1fo01867a · Cited by 39
Characterization of a cashew allergen, 11S globulin (Ana o 2), conformational epitope
Robotham, J. M., Xia, L., Willison, L. N., Teuber, S. S., Sathe, S. K., & Roux, K. H. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2009.12.009 · Cited by 39
Diagnosing Peanut Allergy with Fewer Oral Food Challenges
Koplin, J. J., Perrett, K. P., & Sampson, H. A. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.11.010 · Cited by 38
Self-citation
Native and denatured egg white protein IgE tests discriminate hen's egg allergic from egg‐tolerant children
Benhamou, A. H., Borres, M. P., & Eigenmann, P. (2014) · Pediatric Allergy and Immunology · doi:10.1111/pai.12317 · Cited by 37
Management of Cow’s Milk Allergy from an Immunological Perspective: What Are the Options?
Knol, E. F., de Jong, N. W., Ulfman, L. H., & Tiemessen, M. M. (2019) · Nutrients · doi:10.3390/nu11112734 · Cited by 36
Ovomucoid epitope‐specific repertoire of IgE, IgG4, IgG1, IgA1, and IgD antibodies in egg‐allergic children
Suprun, M., Getts, R. C., Grishina, G. T., Tsuang, A. J., Suárez‐Fariñas, M., & Sampson, H. A. (2020) · Allergy · doi:10.1111/all.14357 · Cited by 37
Self-citation
An unfolded variant of the major peanut allergen Ara h 2 with decreased anaphylactic potential
Starkl, P. M., Felix, F., Krishnamurthy, D., Stremnitzer, C., Roth‐Walter, F., Prickett, S. R., Voskamp, A. L., Willensdorfer, A., Szalai, K., Weichselbaumer, M., et al. (2012) · Clinical & Experimental Allergy · doi:10.1111/cea.12031 · Cited by 35
Oral Immunotherapy for Food Allergies
Feuille, E. J., & Nowak-Wegrzyn, A. H. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000445391 · Cited by 35
Standardization ofin vitromethods
Yman, L. (2001) · Allergy · doi:10.1111/j.1398-9995.2001.00921.x · Cited by 35
Characterization of allergenic food proteins for improved diagnostic methods
Beyer, K. (2003) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200306000-00007 · Cited by 35
Mapping Sequential IgE-Binding Epitopes on Major and Minor Egg Allergens
Suprun, M., Sicherer, S. H., Wood, R. A., Jones, S. M., Leung, D. Y. M., Burks, A. W., Dunkin, D., Witmer, M. V., Grishina, G. T., Getts, R. C., et al. (2021) · International Archives of Allergy and Immunology · doi:10.1159/000519618 · Cited by 33
Self-citation

Authors: Cooke, S. K., & Sampson, H. A.
Affiliations: Johns Hopkins University (US)
ORCID: Sampson, H A
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1997-08
Volume: 159
Issue: 4
Pages: 2026-2032
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.159.4.2026
OpenAlex: W1559185201
Cited by: 250
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 1 · 2023: 9 · 2022: 2 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 11 · 2017: 3 · 2016: 8 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 15
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01ai024439-11)
National Institute of Allergy and Infectious Diseases (AI 24439)
National Center for Research Resources (RR 000 52)
Topics: Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
Keywords: ovomucoid, egg allergy, B-cell epitopes, conformational epitopes, IgE binding, IgG binding, T cell proliferation, protein glycosylation, oxidized proteins, reduced protein
MeSH terms: Allergens, Amino Acid Sequence, Child, Food Hypersensitivity, Humans, Immunoglobulin E, Molecular Sequence Data, Ovomucin, T-Lymphocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Allergenic properties of ovomucoid in man

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks