Cited by 250Food Allergy and Anaphylaxis ResearchAllergic Rhinitis and SensitizationDrug-Induced Adverse Reactions

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Allergenic properties of ovomucoid in man

Cooke, S K, Sampson, H A·1997·The Journal of Immunology

DOI 10.4049/jimmunol.159.4.2026

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Abstract

Ovomucoid, the dominant allergen in hen’s egg, is a highly glycosylated protein comprising 186 amino acids arranged in three tandem domains (Gal d 1.1, 1.2, and 1.3). The purpose of this study was to evaluate the allergenic properties of ovomucoid. The three ovomucoid domains were isolated and evaluated with sera from egg allergic patients to determine B cell domain specificity, B cell epitopes, and the relative importance of linear and conformational structures and carbohydrate chains to B cell epitopes. Peripheral blood T cells from egg allergic patients were used to evaluate T-dominant domains and reactivity to reduced and oxidized ovomucoid. There was significantly more IgE activity to the second ovomucoid domain (median percentage of ovomucoid-specific IgE: Gal d 1.2, 40%; Gal d 1.1, 23%; Gal d 1.3, 26%). Quantities of patient IgG Ab were comparable for all three domains. Five IgE and seven IgG binding regions were identified. IgE Ab binding to reduced ovomucoid and IgG binding to oxidized ovomucoid were significantly reduced compared with that to native ovomucoid (28 and 69%, respectively). Peripheral blood T cells of 21 of 33 patients reacted to Gal d 1.3, 18 of 33 reacted to Gal d 1.2, and 18 of 33 reacted to Gal d 1.1. T cell proliferation in vitro in response to reduced and oxidized ovomucoid were significantly greater than that in response to the native protein. These results indicate a dichotomy between T and B cell domain dominance, and the presence of both unique and common IgE and IgG epitopes. Furthermore, the results suggest that conformational B cell epitopes play a more significant role in ovomucoid allergenicity than previously appreciated, and that carbohydrate moieties have a minor effect on allergenicity.

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Battais, F., Richard, C., & Leduc, V. (2007) · Revue Française d Allergologie et d Immunologie Clinique · doi:10.1016/j.allerg.2007.01.020 · Cited by 3
Update on egg allergy in children
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Tolerance to heated cow's milk and egg in children with allergy to this food
Krogulska, A., Białek, J., & Wąsowska‐Królikowska, K. (2011) · Advances in Dermatology and Allergology · Cited by 3
Isolation and purification of wheat germ agglutinin and analysis of its properties
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Retracted
Food Allergens of Plant and Animal Origin: Classification, Characteristics, and Properties
Moya, B., Dieguez, M. C., Crespo, J. F., & Cabanillas, B. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3453-0_1 · Cited by 2
Novel Strategies for Food Allergy Diagnosis
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Self-citation
Assessment of IgE Reactivity of β-Casein by Western Blotting After Digestion with Simulated Gastric Fluid
Benedé, S., López‐Fandiño, R., & Molina, E. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6925-8_13 · Cited by 2

Authors: Cooke, S. K., & Sampson, H. A.
Affiliations: Johns Hopkins University (US)
ORCID: Sampson, H A
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1997-08
Volume: 159
Issue: 4
Pages: 2026-2032
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.159.4.2026
OpenAlex: W1559185201
Cited by: 250
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 1 · 2023: 9 · 2022: 2 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 11 · 2017: 3 · 2016: 8 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 15
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01ai024439-11)
National Institute of Allergy and Infectious Diseases (AI 24439)
National Center for Research Resources (RR 000 52)
Topics: Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
Keywords: ovomucoid, egg allergy, B-cell epitopes, conformational epitopes, IgE binding, IgG binding, T cell proliferation, protein glycosylation, oxidized proteins, reduced protein
MeSH terms: Allergens, Amino Acid Sequence, Child, Food Hypersensitivity, Humans, Immunoglobulin E, Molecular Sequence Data, Ovomucin, T-Lymphocytes

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Allergenic properties of ovomucoid in man

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