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Cited by 367

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis

Open access
Zimmermann, Stefan, Egeter, Oliver, Hausmann, Susanne, Lipford, Grayson B, Röcken, Martin, Wagner, Hermann, Heeg, Klaus·1998·The Journal of Immunology
DOI 10.4049/jimmunol.160.8.3627
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Abstract

Synthetic oligodeoxynucleotides containing CpG dinucleotides (CpG-ODN) mimic the immunostimulatory qualities of bacterial DNA. We asked whether immunostimulation by CpG-ODN predisposes for a commitment toward a Th1 vs a Th2 response in Leishmania major infection, a model for a lethal Th2-driven disease, in BALB/c mice. CpG-ODN induced Th1 effector T cells in vitro and conveyed protective immunity to disease-prone BALB/c mice in vivo. Conversion to a Th1-driven resistant phenotype was associated with IL-12 production and maintained the expression of IL-12R β2-chains. Most strikingly, CpG-ODN were even curative when given as late as 20 days after lethal L. major infection, indicating that CpG-ODN revert an established Th2 response. These findings imply an important role of bacterial DNA and CpG-ODN in the instruction of adaptive immune responses. They also point to the therapeutic potential of CpG-ODN in redirecting curative Th1 responses in Th2-driven disorders.

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Metadata

Authors
Zimmermann, S., Egeter, O., Hausmann, S., Lipford, G. B., Röcken, M., Wagner, H., & Heeg, K.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
1998-04
Volume
160
Issue
8
Pages
3627-3630
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.160.8.3627
OpenAlex
W4313342408
Cited by
367
References
27
FWCI
45.03
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis. https://app.cochat.ai/papers/10.4049/jimmunol.160.8.3627
The paper
Zimmermann, S., Egeter, O., Hausmann, S., Lipford, G. B., Röcken, M., Wagner, H., & Heeg, K. (1998). Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.160.8.3627

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.