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Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells
Abstract
Signal-regulatory proteins (SIRP) are transmembrane glycoproteins with three extracellular Ig-like domains, closely related to Ag receptors Ig, TCR, and MHC, and a cytoplasmic domain with two immunoreceptor with tyrosine-based inhibition motifs that can interact with src homology 2 domain-containing phosphatases. SIRP have previously been shown to inhibit signaling through receptor tyrosine kinases, but their physiologic function is unknown. Here we demonstrate by expression cloning that the mAbs ED9, ED17, and MRC-OX41 recognize rat SIRP. In addition, we show for the first time that rat SIRP is selectively expressed by myeloid cells (macrophages, monocytes, granulocytes, dendritic cells) and neurons. Moreover, SIRP ligation induces nitric oxide production by macrophages. This implicates SIRP as a putative recognition/signaling receptor in both immune and nervous systems.
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Citations
Cited by
Barclay, A. N., & van den Berg, T. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120142 · Cited by 841
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Chao, M. P., Weissman, I. L., & Majeti, R. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.01.010 · Cited by 649
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Bechmann, I., Galea, I., & Perry, V. H. (2007) · Trends in Immunology · doi:10.1016/j.it.2006.11.007 · Cited by 520
Inflammation, microglia, and alzheimer's disease
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Metadata
- Authors
- Adams, S., van der Laan, L. J. W., Vernon-Wilson, E., Renardel de Lavalette, C., Döpp, E. A., Dijkstra, C. D., Simmons, D. L., & van den Berg, T. K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-08
- Volume
- 161
- Issue
- 4
- Pages
- 1853-1859
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2127122881
- Cited by
- 258
- References
- 0
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Adams, S., van der Laan, L. J. W., Vernon-Wilson, E., Renardel de Lavalette, C., Döpp, E. A., Dijkstra, C. D., Simmons, D. L., & van den Berg, T. K. (1998). Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.161.4.1853
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
