The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target
Abstract
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47 therefore functions as a “don't-eat-me” signal. Here, we discuss recent structural analysis of CD47-SIRPα interactions and implications of this for the function and evolution of SIRPα and paired receptors in general. Furthermore, we review the proposed roles of CD47-SIRPα interactions in phagocytosis, (auto)immunity, and host defense, as well as its potential significance as a therapeutic target in cancer and inflammation and for improving graft survival in xenotransplantation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CD47 antagonizes surface CALR by inhibiting phagocytosis by DCs and macrophages via SIRPA.
“Of note, in some preclinical and clinical instances, the activity of surface-exposed CALR is antagonized by CD47, which operates as a “don’t eat me” signal as it inhibits phagocytosis by DCs and macrophages upon interaction with signal regulatory protein alpha (SIRPA) [885, 886].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [885]
Cites
Role of CD47 as a Marker of Self on Red Blood Cells
Oldenborg, P., Zheleznyak, A., Fang, Y., Lagenaur, C. F., Gresham, H. D., & Lindberg, F. P. (2000) · Science · doi:10.1126/science.288.5473.2051 · Cited by 1,975 · see citing works
Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.045 · Cited by 1,752 · see citing works
Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P. D., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R. K., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,667 · see citing works
CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578 · see citing works
Licensing of natural killer cells by host major histocompatibility complex class I molecules
Kim, S., Poursine‐Laurent, J., Truscott, S. M., Lybarger, L. P., Song, Y.-J., Yang, L., French, A. R., Sunwoo, J. B., Lemieux, S., Hansen, T. H., et al. (2005) · Nature · doi:10.1038/nature03847 · Cited by 1,328 · see citing works
Chao, M. P., Alizadeh, A. A., Tang, C. Z., Myklebust, J. H., Varghese, B., Gill, S. I., Jan, M., Cha, A. C., Chan, C. K. F., Tan, B. T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.044 · Cited by 1,095 · see citing works
Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles
Rodriguez, P. L., Harada, T., Christian, D. A., Pantano, D. A., Tsai, R. K., & Discher, D. E. (2013) · Science · doi:10.1126/science.1229568 · Cited by 985 · see citing works
Integrin-associated protein (CD47) and its ligands
Brown, E. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01906-1 · Cited by 880 · see citing works
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
Agrawal, A., Eastman, Q. M., & Schatz, D. G. (1998) · Nature · doi:10.1038/29457 · Cited by 811 · see citing works
Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001375 · Cited by 776 · see citing works
A unique natural human IgG antibody with anti-alpha-galactosyl specificity.
Galili, U., Rachmilewitz, E. A., Peleg, A., & Flechner, I. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.5.1519 · Cited by 705 · see citing works
Tseng, D., Volkmer, J.-P., Willingham, S. B., Contreras-Trujillo, H., Fathman, J. W., Fernhoff, N. B., Seita, J., Inlay, M. A., Weiskopf, K., Miyanishi, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305569110 · Cited by 656 · see citing works
The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications
Chao, M. P., Weissman, I. L., & Majeti, R. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.01.010 · Cited by 648 · see citing works
Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice
Lindberg, F. P., Bullard, D. C., Caver, T. E., Gresham, H. D., Beaudet, A. L., & Brown, E. J. (1996) · Science · doi:10.1126/science.274.5288.795 · Cited by 606 · see citing works
Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells
Takenaka, K., Prasolava, T. K., Wang, J. C. Y., Mortin-Toth, S. M., Khalouei, S., Gan, O. I., Dick, J. E., & Danska, J. S. (2007) · Nature Immunology · doi:10.1038/ni1527 · Cited by 510 · see citing works
Molecular Interactions Mediating T Cell Antigen Recognition
van der Merwe, P. A., & Davis, S. J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141036 · Cited by 501 · see citing works
Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies
Weiskopf, K., Ring, A. M., Ho, C. C. M., Volkmer, J.-P., Levin, A. M., Volkmer, A. K., Özkan, E., Fernhoff, N. B., van de Rijn, M., Weissman, I. L., et al. (2013) · Science · doi:10.1126/science.1238856 · Cited by 493 · see citing works
Tsai, R. K., & Discher, D. E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708043 · Cited by 486 · see citing works
Functions and molecular mechanisms of the CD47–SIRPα signalling pathway
Matozaki, T., Murata, Y., Okazawa, H., & Ohnishi, H. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.12.001 · Cited by 477 · see citing works
Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor–Mediated Phagocytosis
Oldenborg, P., Gresham, H. D., & Lindberg, F. P. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.855 · Cited by 453 · see citing works
Fujioka, Y., Matozaki, T., Noguchi, T., Iwamatsu, A., Yamao, T., Takahashi, N., Tsuda, M., Takada, T., & Kasuga, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6887 · Cited by 448 · see citing works
The SIRP family of receptors and immune regulation
Barclay, A. N., & Brown, M. H. (2006) · Nature reviews. Immunology · doi:10.1038/nri1859 · Cited by 427 · see citing works
Self-citationTherapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia
Chao, M. P., Alizadeh, A. A., Tang, C. Z., Jan, M., Weissman-Tsukamoto, R., Zhao, F., Park, C. Y., Weissman, I. L., & Majeti, R. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2238 · Cited by 381 · see citing works
SHP‐1 and SHP‐2 in T cells: two phosphatases functioning at many levels
Lorenz, U. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00760.x · Cited by 370 · see citing works
Integrin-associated Protein Is a Ligand for the P84 Neural Adhesion Molecule
Jiang, P., Lagenaur, C. F., & Narayanan, V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.559 · Cited by 353 · see citing works
CD47 functions as a molecular switch for erythrocyte phagocytosis
Burger, P., Hilarius-Stokman, P., de Korte, D., van den Berg, T. K., & van Bruggen, R. (2012) · Blood · doi:10.1182/blood-2011-10-386805 · Cited by 338 · see citing works
Role for CD47-SIRPα signaling in xenograft rejection by macrophages
Ide, K., Wang, H., Tahara, H., Liu, J., Wang, X., Asahara, T., Sykes, M., Yang, Y., & Ohdan, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609661104 · Cited by 310 · see citing works
Hu, C. J., Fang, R. H., Luk, B. T., Chen, K. N. H., Carpenter, C. W., Gao, W., Zhang, K., & Zhang, L. (2013) · Nanoscale · doi:10.1039/c3nr00015j · Cited by 310 · see citing works
Seiffert, M., Cant, C., Chen, Z., Rappold, I., Brugger, W., Kanz, L., Brown, E. J., Ullrich, A., & Bühring, H. (1999) · Blood · doi:10.1182/blood.v94.11.3633 · Cited by 305 · see citing works
Negative Regulation of Phagocytosis in Macrophages by the CD47-SHPS-1 System
Okazawa, H., Motegi, S., Ohyama, N., Ohnishi, H., Tomizawa, T., Kaneko, Y., Oldenborg, P., Ishikawa, O., & Matozaki, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2004 · Cited by 303 · see citing works
Zhao, X. W., van Beek, E. M., Schornagel, K., van der Maaden, H., van Houdt, M., Otten, M. A., Finetti, P., van Egmond, M., Matozaki, T., Kraal, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106550108 · Cited by 275 · see citing works
Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells
Adams, S., van der Laan, L. J. W., Vernon-Wilson, E. F., de Lavalette, C. R., Döpp, E. A., Dijkstra, C. D., Simmons, D. L., & van den Berg, T. K. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.4.1853 · Cited by 260 · see citing works
Veillette, A., Thibaudeau, E., & Latour, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22719 · Cited by 247 · see citing works
One Step Ahead of the Game: Viral Immunomodulatory Molecules
Spriggs, M. K. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.101 · Cited by 242 · see citing works
Macrophages as mediators of tumor immunosurveillance
Jaiswal, S., Chao, M. P., Majeti, R., & Weissman, I. L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.04.001 · Cited by 241 · see citing works
Latour, S., Tanaka, H., Demeure, C. E., Mateo, V., Rubio, M., Brown, E. J., Maliszewski, C. R., Lindberg, F. P., Oldenborg, A., Ullrich, A., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2547 · Cited by 238 · see citing works
Oldenborg, P. (2013) · ISRN Hematology · doi:10.1155/2013/614619 · Cited by 235 · see citing works
Strowig, T., Rongvaux, A., Rathinam, C., Takizawa, H., Borsotti, C., Philbrick, W. M., Eynon, E. E., Manz, M. G., & Flavell, R. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109769108 · Cited by 228 · see citing works
Signal Regulatory Protein (SIRPα), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration
Liu, Y., Bühring, H., Zen, K., Burst, S. L., Schnell, F. J., Williams, I. R., & Parkos, C. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109720200 · Cited by 217 · see citing works
Olsson, M., Bruhns, P., Frazier, W. A., Ravetch, J. V., & Oldenborg, P. (2005) · Blood · doi:10.1182/blood-2004-08-2980 · Cited by 216 · see citing works
Hatherley, D., Graham, S. C., Turner, J., Harlos, K., Stuart, D. I., & Barclay, A. N. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.026 · Cited by 216 · see citing works
Self-citationAbi‐Rached, L., & Parham, P. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042558 · Cited by 212 · see citing works
van Spriel, A. B., Leusen, J. H. W., van Egmond, M., Dijkman, H. B. P. M., Assmann, K. J. M., Mayadas, T. N., & van de Winkel, J. G. J. (2001) · Blood · doi:10.1182/blood.v97.8.2478 · Cited by 210 · see citing works
Legrand, N., Huntington, N. D., Nagasawa, M., Bakker, A. Q., Schotte, R., Strick‐Marchand, H., de Geus, S. J., Pouw, S. M., Böhne, M., Voordouw, A. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101398108 · Cited by 206 · see citing works
Signal Regulatory Proteins in the Immune System
van Beek, E. M., Cochrane, F., Barclay, A. N., & van den Berg, T. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.7781 · Cited by 204 · see citing works
Self-citationSurfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα
Janssen, W. J., McPhillips, K. A., Dickinson, M. G., Linderman, D. J., Morimoto, K., Xiao, Y. Q., Oldham, K. M., Vandivier, R. W., Henson, P. M., & Gardai, S. J. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200711-1661oc · Cited by 203 · see citing works
Eck, M. J., Pluskey, S., Trüb, T., Harrison, S. C., & Shoelson, S. E. (1996) · Nature · doi:10.1038/379277a0 · Cited by 199 · see citing works
Chao, M. P., Tang, C. Z., Pachynski, R. K., Chin, R., Majeti, R., & Weissman, I. L. (2011) · Blood · doi:10.1182/blood-2011-02-338020 · Cited by 196 · see citing works
Nairz, M., Schroll, A., Moschen, A. R., Sonnweber, T., Theurl, M., Theurl, I., Taub, N., Jamnig, C., Neurauter, D., Huber, L. A., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.002 · Cited by 194 · see citing works
The Role of CD47 in Neutrophil Transmigration
Liu, Y., Merlin, D., Burst, S. L., Pochet, M., Madara, J., & Parkos, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104138200 · Cited by 191 · see citing works
Wang, Y., Xu, Z., Guo, S., Zhang, L., Sharma, A. K., Robertson, G. P., & Huang, L. (2013) · Molecular Therapy · doi:10.1038/mt.2013.135 · Cited by 191 · see citing works
Seiffert, M., Brossart, P., Cant, C., Cella, M., Colonna, M., Brugger, W., Kanz, L., Ullrich, A., & Bühring, H. (2001) · Blood · doi:10.1182/blood.v97.9.2741 · Cited by 183 · see citing works
Kretz-Rommel, A., Qin, F., Dakappagari, N. K., Ravey, E. P., McWhirter, J. R., Oltean, D. I., Frederickson, S., Maruyama, T., Wild, M. A., Nolan, M. J., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5595 · Cited by 175 · see citing works
CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPα 1
Vernon-Wilson, E. F., Kee, W.-J., Willis, A. C., Barclay, A. N., Simmons, D. L., & Brown, M. H. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(2000)30:18 · Cited by 175 · see citing works
Self-citationDietrich, J., Cella, M., Seiffert, M., Bühring, H., & Colonna, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.9 · Cited by 172 · see citing works
Brooke, G. P., Holbrook, J. D., Brown, M. H., & Barclay, A. N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2562 · Cited by 171 · see citing works
Self-citationJanus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice
Han, M. H., Lundgren, D. H., Jaiswal, S., Chao, M., Graham, K. L., Garris, C. S., Axtell, R. C., Ho, P. P., Lock, C. B., Woodard, J. I., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20101974 · Cited by 157 · see citing works
Gitik, M., Zaltsman, S. L., Oldenborg, P., Reichert, F., & Rotshenker, S. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-24 · Cited by 148 · see citing works
Tsai, R. K., Rodriguez, P. L., & Discher, D. E. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.02.016 · Cited by 143 · see citing works
Yamauchi, T., Takenaka, K., Urata, S., Shima, T., Kikushige, Y., Tokuyama, T., Iwamoto, C., Nishihara, M., Iwasaki, H., Miyamoto, T., et al. (2013) · Blood · doi:10.1182/blood-2012-06-440354 · Cited by 143 · see citing works
Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2
Tsuda, M., Matozaki, T., Fukunaga, K., Fujioka, Y., Imamoto, A., Noguchi, T., Takada, T., Yamao, T., Takeda, H., Ochi, F., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13223 · Cited by 143 · see citing works
Campbell, I., Freemont, P. S., Foulkes, W. D., & Trowsdale, J. (1992) · PubMed · Cited by 140 · see citing works
Face off — the interplay between activating and inhibitory immune receptors
Lanier, L. L. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00222-3 · Cited by 139 · see citing works
Yamao, T., Noguchi, T., Takeuchi, O., Nishiyama, U., Morita, H., Hagiwara, T., Akahori, H., Kato, T., Inagaki, K., Okazawa, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203287200 · Cited by 139 · see citing works
Kaur, S., Soto‐Pantoja, D. R., Stein, E. V., Liu, C., ELKAHLOUN, A. G., Pendrak, M. L., Nicolae, A., SINGH, S. P., Nie, Z., Levens, D., et al. (2013) · Scientific Reports · doi:10.1038/srep01673 · Cited by 138 · see citing works
SHPS‐1 regulates integrin‐mediated cytoskeletal reorganization and cell motility
Inagaki, K., Yamao, T., Noguchi, T., Matozaki, T., Fukunaga, K., Takada, T., Hosooka, T., Akira, S., & Kasuga, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6721 · Cited by 138 · see citing works
Theocharides, A. P. A., Jin, L., Cheng, P.-Y., Prasolava, T. K., Malko, A. V., Ho, J., Poeppl, A. G., van Rooijen, N., Minden, M. D., Danska, J. S., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120502 · Cited by 136 · see citing works
de Vries, H. E., Hendriks, J. J. A., Honing, H., de Lavalette, C. R., van der Pol, S. M. A., Hooijberg, E., Dijkstra, C. D., & van den Berg, T. K. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5832 · Cited by 135 · see citing works
Richards, D. F., Fernandez, M., Caulfield, J., & Hawrylowicz, C. M. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(2000)30:8 · Cited by 133 · see citing works
Kong, X., Yan, H., Chen, L., Dong, L., Yang, W., Liu, Q., Yu, L., Huang, D., Liu, S., Liu, H., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062611 · Cited by 131 · see citing works
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47
Wang, H., VerHalen, J., Madariaga, M. L. L., Xiang, S., Wang, S., Lan, P., Oldenborg, P., Sykes, M., & Yang, Y. (2006) · Blood · doi:10.1182/blood-2006-04-019794 · Cited by 130 · see citing works
Piccio, L. M., Vermi, W., Boles, K. S., Fuchs, A. G., Strader, C., Facchetti, F., Cella, M., & Colonna, M. (2004) · Blood · doi:10.1182/blood-2004-07-2823 · Cited by 124 · see citing works
Takada, T., Matozaki, T., Takeda, H., Fukunaga, K., Noguchi, T., Fujioka, Y., Okazaki, I., Tsuda, M., Yamao, T., Ochi, F., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.9234 · Cited by 112 · see citing works
Timms, J. F., Swanson, K. D., Marie‐Cardine, A., Raab, M., Rudd, C. E., Schraven, B. L., & Neel, B. G. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80401-1 · Cited by 111 · see citing works
Thrombospondin-1 Regulates Blood Flow via CD47 Receptor–Mediated Activation of NADPH Oxidase 1
Csányi, G., Yao, M., Rodriguez, A. I., Ghouleh, I. A., Sharifi‐Sanjani, M., Frazziano, G., Huang, X., Kelley, E. E., Isenberg, J. S., & Pagano, P. J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300031 · Cited by 109 · see citing works
Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice
Oldenborg, P. (2002) · Blood · doi:10.1182/blood.v99.10.3500 · Cited by 108 · see citing works
Bian, Z., Guo, Y.-L., Ha, B., Zen, K., & Liu, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101736 · Cited by 107 · see citing works
Evolution of the Ly49 and Nkrp1 recognition systems
Carlyle, J. R., Mesci, A., Fine, J. H., Chen, P., Bélanger, S., Tai, L., & Makrigiannis, A. P. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.05.004 · Cited by 103 · see citing works
Kim, M. J., Lee, J.-C., Lee, J., Kim, S., Lee, S. G., Park, S., Sung, M. W., & Heo, D. S. (2008) · Tumor Biology · doi:10.1159/000132568 · Cited by 101 · see citing works
Subsets of migrating intestinal dendritic cells
Milling, S. W. F., Yrlid, U., Cerovic, V., & MacPherson, G. G. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00866.x · Cited by 101 · see citing works
Stefanidakis, M., Newton, G. A., Lee, W. Y., Parkos, C. A., & Luscinskas, F. W. (2008) · Blood · doi:10.1182/blood-2008-01-134429 · Cited by 99 · see citing works
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47 null cells
Wang, H., Madariaga, M. L. L., Wang, S., van Rooijen, N., Oldenborg, P., & Yang, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702881104 · Cited by 94 · see citing works
On the origins of adaptive immunity: innate immune receptors join the tale
VandenBerg, T., Yoder, J. A., & Litman, G. W. (2003) · Trends in Immunology · doi:10.1016/j.it.2003.11.006 · Cited by 93 · see citing works
Self-citationCell polarisation and the immunological synapse
Angus, K. L., & Griffiths, G. M. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.013 · Cited by 93 · see citing works
Van, V. Q., Lesage, S., Bouguermouh, S., Gautier, P., Rubio, M., Lévesque, M., Nguyen, S., Galibert, L., & Sarfati, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601415 · Cited by 92 · see citing works
CD200R signaling in tumor tolerance and inflammation: A tricky balance
Rygiel, T. P., & Meyaard, L. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.01.002 · Cited by 88 · see citing works
Role of the CD47–SHPS‐1 system in regulation of cell migration
Motegi, S., Okazawa, H., Ohnishi, H., Sato, R., Kaneko, Y., Kobayashi, H., Tomizawa, K., Ito, T., Honma, N., Bühring, H., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg278 · Cited by 87 · see citing works
How the immune system talks to itself: the varied role of synapses
Xie, J., Tato, C. M., & Davis, M. M. (2012) · Immunological Reviews · doi:10.1111/imr.12017 · Cited by 85 · see citing works
Jackson, A., Nanton, M. R., O’Donnell, H., Akue, A. D., & McSorley, S. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001198 · Cited by 85 · see citing works
Raymond, M., Rubio, M., Fortin, G., Shalaby, K. H., Hammad, H., Lambrecht, B. N., & Sarfati, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.021 · Cited by 84 · see citing works
A role for CD47 in the development of experimental colitis mediated by SIRPα+CD103− dendritic cells
Fortin, G., Raymond, M., Van, V. Q., Rubio, M., Gautier, P., Sarfati, M., & Franchimont, D. P. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082805 · Cited by 80 · see citing works
Hatherley, D., Harlos, K., Dunlop, D. C., Stuart, D. I., & Barclay, A. N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611511200 · Cited by 78 · see citing works
Self-citationvan den Berg, T. K., & van der Schoot, C. E. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.02.004 · Cited by 78 · see citing works
Cameron, C., Barrett, J. W., Mann, M. J., Lucas, A., & McFadden, G. (2005) · Virology · doi:10.1016/j.virol.2005.03.037 · Cited by 74 · see citing works
Su, X., Johansen, M. L., Looney, M. R., Brown, E. J., & Matthay, M. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6947 · Cited by 70 · see citing works
Kuriyama, T., Takenaka, K., Kohno, K., Yamauchi, T., Daitoku, S., Yoshimoto, G., Kikushige, Y., Kishimoto, J., Abe, Y., Harada, N., et al. (2012) · Blood · doi:10.1182/blood-2012-02-408864 · Cited by 67 · see citing works
Subramanian, S., Boder, E. T., & Discher, D. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603923200 · Cited by 66 · see citing works
Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47
Soto‐Pantoja, D. R., Stein, E. V., Rogers, N. M., Sharifi‐Sanjani, M., Isenberg, J. S., & Roberts, D. D. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.733699 · Cited by 65 · see citing works
Mi, Z. P., Jiang, P., Weng, W., Lindberg, F. P., Narayanan, V., & Lagenaur, C. F. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000117)416:3 · Cited by 65 · see citing works
The Counterbalance Theory for Evolution and Function of Paired Receptors
Barclay, A. N., & Hatherley, D. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.004 · Cited by 65 · see citing works
Self-citationStructures of CD200/CD200 Receptor Family and Implications for Topology, Regulation, and Evolution
Hatherley, D., Lea, S. M., Johnson, S., & Barclay, A. N. (2013) · Structure · doi:10.1016/j.str.2013.03.008 · Cited by 65 · see citing works
Self-citationMacrophage Activation by Immunostimulatory DNA
Stacey, K. J., Sester, D. P., Sweet, M. J., & Hume, D. A. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59672-8_3 · Cited by 64 · see citing works
Dual Regulation of SIRPα Phosphorylation by Integrins and CD47
Johansen, M. L., & Brown, E. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701565200 · Cited by 59 · see citing works
Liu, Y., O’Connor, M. B., Mandell, K. J., Zen, K., Ullrich, A., Bühring, H., & Parkos, C. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2578 · Cited by 58 · see citing works
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement
Alenghat, F. J., Baca, Q. J., Rubin, N. T., Pao, L. I., Matozaki, T., Lowell, C. A., Golan, D. E., Neel, B. G., & Swanson, K. D. (2012) · Journal of Cell Science · doi:10.1242/jcs.111260 · Cited by 58 · see citing works
Molecular Recognition of Paired Receptors in the Immune System
Kuroki, K., Furukawa, A., & Maenaka, K. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00429 · Cited by 56 · see citing works
Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia
Uno, S., Kinoshita, Y., Azuma, Y., Tsunenari, T., Yoshimura, Y., Iida, S., Kikuchi, Y., Yamada‐Okabe, H., & Fukushima, N. (2007) · Oncology Reports · doi:10.3892/or.17.5.1189 · Cited by 56 · see citing works
Expression of CD200 on AML blasts directly suppresses memory T-cell function
Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S., Darley, R. L., & Tonks, A. (2012) · Leukemia · doi:10.1038/leu.2012.77 · Cited by 55 · see citing works
Baba, N., Van, V. Q., Wakahara, K., Rubio, M., Fortin, G., Panzini, B., Soucy, G., Wassef, R., Richard, C. S., Tamaz, R., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122037 · Cited by 54 · see citing works
Signal Regulatory Proteins (SIRPS) Are Secreted Presynaptic Organizing Molecules
Umemori, H., & Sanes, J. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805729200 · Cited by 53 · see citing works
Tomizawa, T., Kaneko, Y., Kaneko, Y., Saito, Y., Ohnishi, H., Okajo, J., Okuzawa, C., Ishikawa-Sekigami, T., Murata, Y., Okazawa, H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.869 · Cited by 52 · see citing works
Dong, L., Kong, X., Yan, H., Yu, L., Chen, L., Yang, W., Liu, Q., Huang, D., Wu, M., & Wang, H. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.03.012 · Cited by 50 · see citing works
An essential role for the association of CD47 to SHPS-1 in skeletal remodeling
Maile, L. A., DeMambro, V., Wai, C., Aday, A. W., Capps, B. E., Beamer, W. G., Rosen, C. J., & Clemmons, D. R. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.441 · Cited by 45 · see citing works
The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35/CD300L
Viertlboeck, B. C., Schmitt, R., & Göbel, T. (2006) · Immunogenetics · doi:10.1007/s00251-006-0091-8 · Cited by 45 · see citing works
Structure of Signal-regulatory Protein α
Hatherley, D., Graham, S. C., Harlos, K., Stuart, D. I., & Barclay, A. N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017566 · Cited by 44 · see citing works
Self-citationNovel CD47-dependent intercellular adhesion modulates cell migration
Rebres, R. A., Kajihara, K. K., & Brown, E. J. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20379 · Cited by 44 · see citing works
Fukunaga, A., Nagai, H., Noguchi, T., Okazawa, H., Matozaki, T., Yu, X., Lagenaur, C. F., Honma, N., Ichihashi, M., Kasuga, M., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4091 · Cited by 44 · see citing works
How do pathogens drive the evolution of paired receptors?
Akkaya, M., & Barclay, A. N. (2012) · European Journal of Immunology · doi:10.1002/eji.201242896 · Cited by 42 · see citing works
Self-citationCD47 Is Required for Suppression of Allograft Rejection by Donor-Specific Transfusion
Wang, H., Wu, X., Wang, Y., Oldenborg, P., & Yang, Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901550 · Cited by 39 · see citing works
Barros, M. M. O., Yamamoto, M., Figueiredo, M. S., Cançado, R. D., Kimura, E. Y. S., Langhi, D. M., CHIATTONE, C. S., & Bordin, J. O. (2008) · Transfusion · doi:10.1111/j.1537-2995.2008.01936.x · Cited by 39 · see citing works
Signal Regulatory Protein α Regulates the Homeostasis of T Lymphocytes in the Spleen
Sato‐Hashimoto, M., Saito, Y., Ohnishi, H., Iwamura, H., Kanazawa, Y., Kaneko, T., Kusakari, S., Kotani, T., Mori, M., Murata, Y., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100528 · Cited by 37 · see citing works
SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone.
Carter‐Su, C., Rui, L., & Stofega, M. R. (2000) · PubMed · Cited by 36 · see citing works
Braun, D., Galibert, L., Nakajima, T., Saito, H., Van, V. Q., Rubio, M., & Sarfati, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8550 · Cited by 36 · see citing works
On the mechanism of CD47 targeting in cancer
Zhao, X. W., Matlung, H. L., Kuijpers, T. W., & van den Berg, T. K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209265109 · Cited by 35 · see citing works
Sagawa, M., Shimizu, T., Fukushima, N., Kinoshita, Y., Ohizumi, I., Uno, S., Kikuchi, Y., Ikeda, Y., Yamada‐Okabe, H., & Kizaki, M. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01925.x · Cited by 34 · see citing works
A Nomenclature for Signal Regulatory Protein Family Members
van den Berg, T. K., van Beek, E. M., Bühring, H.-J., Colonna, M., Hamaguchi, M., Howard, C. J., Kasuga, M., Liu, Y., Matozaki, T., Neel, B. G., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.7788 · Cited by 33 · see citing works
Self-citationIs targeting of CD47-SIRPα enough for treating hematopoietic malignancy?
Zhao, X. W., Kuijpers, T. W., & van den Berg, T. K. (2012) · Blood · doi:10.1182/blood-2011-11-391367 · Cited by 32 · see citing works
SIRPα Controls the Activity of the Phagocyte NADPH Oxidase by Restricting the Expression of gp91phox
van Beek, E. M., Zárate, J. Á., van Bruggen, R., Schornagel, K., Tool, A. T. J., Matozaki, T., Kraal, G., Roos, D., & van den Berg, T. K. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.027 · Cited by 31 · see citing works
Wang, C., Wang, H., Ide, K., Wang, Y., van Rooijen, N., Ohdan, H., & Yang, Y. (2011) · Cell Transplantation · doi:10.3727/096368911x566253 · Cited by 31 · see citing works
Navarro–Álvarez, N., & Yang, Y. (2013) · Cell Transplantation · doi:10.3727/096368913x663604 · Cited by 31 · see citing works
Inhibition of Macrophage Activation by the Myxoma Virus M141 Protein (vCD200)
Zhang, L., Stanford, M. M., Liu, J., Barrett, C., Jiang, L., Barclay, A. N., & McFadden, G. (2009) · Journal of Virology · doi:10.1128/jvi.01078-09 · Cited by 31 · see citing works
Self-citationBeattie, L., Svensson, M., Bune, A. J., Brown, N., Maroof, A., Zubairi, S., Smith, K. R., & Kaye, P. M. (2009) · European Journal of Immunology · doi:10.1002/eji.200939863 · Cited by 30 · see citing works
Fournier, B., Andargachew, R., Robin, A. Z., Laur, O., Voelker, D. R., Lee, W. Y., Weber, D. A., & Parkos, C. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324533 · Cited by 28 · see citing works
The CD47 pathway is deregulated in human immune thrombocytopenia
Catani, L., Sollazzo, D., Ricci, F., Polverelli, N., Palandri, F., Baccarani, M., Vianelli, N., & Lemoli, R. M. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2010.12.011 · Cited by 27 · see citing works
Structural Insight into the Specific Interaction between Murine SHPS-1/SIRPα and Its Ligand CD47
Nakaishi, A., Hirose, M., Yoshimura, M., Oneyama, C., Saito, K., Kuki, N., Matsuda, M., Honma, N., Ohnishi, H., Matozaki, T., et al. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.10.085 · Cited by 25 · see citing works
Soto‐Pantoja, D. R., Miller, T. W., Frazier, W. A., & Roberts, D. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205441109 · Cited by 25 · see citing works
Resistance to collagen-induced arthritis in SHPS-1 mutant mice
Okuzawa, C., Kaneko, Y., Murata, Y., Miyake, A., Saito, Y., Okajo, J., Tomizawa, T., Kaneko, Y., Okazawa, H., Ohnishi, H., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.124 · Cited by 25 · see citing works
CD47high Expression on CD4 Effectors Identifies Functional Long-Lived Memory T Cell Progenitors
Van, V. Q., Raymond, M., Baba, N., Rubio, M., Wakahara, K., Susín, S. A., & Sarfati, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102702 · Cited by 25 · see citing works
Okajo, J., Kaneko, Y., Murata, Y., Tomizawa, T., Okuzawa, C., Saito, Y., Kaneko, Y., Ishikawa-Sekigami, T., Okazawa, H., Ohnishi, H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6164 · Cited by 24 · see citing works
Verdrengh, M., Lindberg, F. P., Rydèn, C., & Tarkowski, A. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)80076-8 · Cited by 24 · see citing works
Paired Receptor Systems of the Innate Immune System
Yamada, E., & McVicar, D. W. (2008) · Current Protocols in Immunology · doi:10.1002/0471142735.ima01xs81 · Cited by 22 · see citing works
Waern, J., Yuan, Q., Rüdrich, U., Becker, P. D., Schulze, K., Strick‐Marchand, H., Huntington, N. D., Zacher, B. J., Wursthorn, K., Santo, J. P. D., et al. (2012) · Hepatology · doi:10.1002/hep.25816 · Cited by 22 · see citing works
Yu, X., Fukunaga, A., Nagai, H., Oniki, S., Honma, N., Ichihashi, M., Matozaki, T., Nishigori, C., & Horikawa, T. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700176 · Cited by 20 · see citing works
Bian, Z., Guo, Y.-L., Luo, Y., Tremblay, A., Zhang, X., Dharma, S. S., Mishra, A., & Liu, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201963 · Cited by 19 · see citing works
Essential roles of SHPS-1 in induction of contact hypersensitivity of skin
Motegi, S., Okazawa, H., Murata, Y., Kanazawa, Y., Saito, Y., Kobayashi, H., Ohnishi, H., Oldenborg, P., Ishikawa, O., & Matozaki, T. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.08.005 · Cited by 18 · see citing works
Irandoust, M. I., Zárate, J. Á., Hubeek, I., van Beek, E. M., Schornagel, K., Broekhuizen, A. J. F., Akyuz, M., van de Loosdrecht, A. A., Delwel, R., Valk, P. J. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052143 · Cited by 18 · see citing works
Targeting SIRP‐α protects from type 2‐driven allergic airway inflammation
Raymond, M., Van, V. Q., Rubio, M., Welzenbach, K., & Sarfati, M. (2010) · European Journal of Immunology · doi:10.1002/eji.201040797 · Cited by 17 · see citing works
Kobayashi, M., Ohnishi, H., Okazawa, H., Murata, Y., Hayashi, Y., Kobayashi, H., Kitamura, T., & Matozaki, T. (2008) · Endocrinology · doi:10.1210/en.2008-0236 · Cited by 17 · see citing works
Ahrens, N., Pagenkopf, C., Kiesewetter, H., & Salama, A. (2006) · Transfusion Medicine · doi:10.1111/j.1365-3148.2006.00688.x · Cited by 17 · see citing works
Nettleship, J. E., Ren, J., Scott, D. J., Rahman, N., Hatherley, D., Zhao, Y., Stuart, D. I., Barclay, A. N., & Owens, R. J. (2013) · BMC Structural Biology · doi:10.1186/1472-6807-13-13 · Cited by 14 · see citing works
Self-citationBaral, P., & Utaisincharoen, P. (2012) · Infection and Immunity · doi:10.1128/iai.00718-12 · Cited by 14 · see citing works
Increased Susceptibility to Salmonella Infection in Signal Regulatory Protein α-Deficient Mice
Li, L., Atif, S. M., Schmiel, S. E., Lee, S., & McSorley, S. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200429 · Cited by 13 · see citing works
Survival and function of CD47‐deficient thymic grafts in mice
Wang, Y., Wang, H., Wang, S., Fu, Y., & Yang, Y. (2010) · Xenotransplantation · doi:10.1111/j.1399-3089.2010.00578.x · Cited by 11 · see citing works
Tanaka, K., Horikawa, T., Suzuki, S., Kitaura, K., Watanabe, J. A., Gotoh, A., Shiobara, N., Itoh, T., Yamane, S., Suzuki, R., et al. (2008) · The Journal of Rheumatology · doi:10.3899/jrheum.080369 · Cited by 9 · see citing works
Requirement of SIRPα for protective immunity against Leishmania major
Morimoto, N., Murata, Y., Motegi, S., Suzue, K., Saito, Y., Okazawa, H., Ohnishi, H., Kotani, T., Kusakari, S., Ishikawa, O., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.062 · Cited by 5 · see citing works
Lymphoma spread? Target CD47-SIRPα!
Spaargaren, M. (2011) · Blood · doi:10.1182/blood-2011-09-375139 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Targeting macrophages: therapeutic approaches in cancer
Cassetta, L., & Pollard, J. W. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.169 · Cited by 2,057 · see citing works
Tumor microenvironment as a therapeutic target in cancer
Xiao, Y. Q., & Yu, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107753 · Cited by 1,977 · see citing works
Apoptosis and Clearance of Apoptotic Cells
Nagata, S. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053010 · Cited by 1,107 · see citing works
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000 · see citing works
Phagocytosis of apoptotic cells in homeostasis
Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959 · see citing works
Targeting tumor-associated macrophages in cancer
Pathria, P., Louis, T. L., & Varner, J. A. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.02.003 · Cited by 933 · see citing works
Phagocytosis checkpoints as new targets for cancer immunotherapy
Feng, M., Jiang, W., Kim, B. Y. S., Zhang, C. C., Fu, Y., & Weissman, I. L. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0183-z · Cited by 914 · see citing works
An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure
Segawa, K., & Nagata, S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.08.003 · Cited by 778 · see citing works
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
Liu, X., Pu, Y., Cron, K. R., Deng, L., Kline, J. P., Frazier, W. A., Xu, H., Peng, H., Fu, Y., & Xu, M. M. (2015) · Nature Medicine · doi:10.1038/nm.3931 · Cited by 770 · see citing works
Xia, Q., Zhang, Y., Li, Z., Hou, X., & Feng, N. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.01.011 · Cited by 671 · see citing works
Sloan, S. A., Darmanis, S., Huber, N., Khan, T. A., Birey, F., Caneda, C., Reimer, R., Quake, S. R., Barres, B. A., & Paşca, S. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.035 · Cited by 593 · see citing works
The CD47‐SIRPα signaling axis as an innate immune checkpoint in cancer
Matlung, H. L., Szilagyi, K., Barclay, N., & van den Berg, T. K. (2017) · Immunological Reviews · doi:10.1111/imr.12527 · Cited by 563 · see citing works
SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy
Veillette, A., & Chen, J. (2018) · Trends in Immunology · doi:10.1016/j.it.2017.12.005 · Cited by 476 · see citing works
Beyond immune checkpoint blockade: emerging immunological strategies
Kubli, S. P., Berger, T., Araújo, D. V., Siu, L. L., & Mak, T. W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00155-y · Cited by 460 · see citing works
How macrophages deal with death
Lemke, G. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0167-y · Cited by 437 · see citing works
Platelet membrane-camouflaged magnetic nanoparticles for ferroptosis-enhanced cancer immunotherapy
Jiang, Q., Wang, K., Zhang, X., Ouyang, B., Liu, H., Pang, Z., & Yang, W. (2020) · Small · doi:10.1002/smll.202001704 · Cited by 426 · see citing works
Gholamin, S., Mitra, S. S., Feroze, A. H., Liu, J., Kahn, S. A., Zhang, M., Esparza, R., Richard, C., Ramaswamy, V., Remke, M., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2968 · Cited by 422 · see citing works
Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis
Matlung, H. L., Babes, L., Zhao, X. W., van Houdt, M., Treffers, L. W., van Rees, D. J., Franke, K., Schornagel, K., Verkuijlen, P., Janssen, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.082 · Cited by 406 · see citing works
Phenotype, function, and differentiation potential of human monocyte subsets
Boyette, L. B., Macedo, C., Hadi, K., Elinoff, B. D., Walters, J., Ramaswami, B., Chalasani, G., Taboas, J. M., Lakkis, F. G., & Metes, D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176460 · Cited by 401 · see citing works
Jiang, Q., Liu, Y., Guo, R., Yao, X., Sung, S., Pang, Z., & Yang, W. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.021 · Cited by 400 · see citing works
Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles
Kroll, A. V., Fang, R. H., & Zhang, L. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00569 · Cited by 386 · see citing works
Durable antitumor responses to CD47 blockade require adaptive immune stimulation
Sockolosky, J. T., Dougan, M., Ingram, J. R., Ho, C. C. M., Kauke, M. J., Almo, S. C., Ploegh, H. L., & Garcia, K. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604268113 · Cited by 366 · see citing works
Harnessing tumor‐associated macrophages as aids for cancer immunotherapy
Li, X., Liu, R., Su, X., Pan, Y., Han, X., Shao, C., & Shi, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1102-3 · Cited by 364 · see citing works
NK Cell-Based Immune Checkpoint Inhibition
Khan, M. B., Arooj, S., & Wang, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00167 · Cited by 359 · see citing works
Cancer immunotherapy targeting the CD47/SIRPα axis
Weiskopf, K. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.02.013 · Cited by 356 · see citing works
Shaw, A. E., Hughes, J., Gu, Q., Behdenna, A., Singer, J. B., Dennis, T. P. W., Orton, R. J., Varela, M., Gifford, R. J., Wilson, S. J., et al. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2004086 · Cited by 341 · see citing works
Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies
Kumari, N., & Choi, S. H. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02272-x · Cited by 324 · see citing works
Xu, M. M., Yang, P., Han, D., Shi, Y., Cao, X., Liang, H. L., Chen, X., Li, X.-D., Deng, L., Chen, Z. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.016 · Cited by 315 · see citing works
Immune Regulation in the Aging Retina
Chen, M., Luo, C., Zhao, J., Devarajan, G., & Xu, H. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.10.003 · Cited by 305 · see citing works
Macrophages are critical effectors of antibody therapies for cancer
Weiskopf, K., & Weissman, I. L. (2015) · mAbs · doi:10.1080/19420862.2015.1011450 · Cited by 294 · see citing works
Bispecific T cell engagers: an emerging therapy for management of hematologic malignancies
Tian, Z., Liu, M., Zhang, Y., & Wang, X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01084-4 · Cited by 288 · see citing works
SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin
Chen, J., Zhong, M., Guo, H., Davidson, D., Mishel, S., Lü, Y., Rhee, I., Pérez‐Quintero, L., Zhang, S., Cruz‐Munoz, M., et al. (2017) · Nature · doi:10.1038/nature22076 · Cited by 287 · see citing works
Emerging phagocytosis checkpoints in cancer immunotherapy
Liu, Y., Wang, Y., Yang, Y., Weng, L., Wu, Q., Zhang, J., Zhao, P., Fang, L., Shi, Y., & Wang, P. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01365-z · Cited by 287 · see citing works
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity
Ring, N. G., Herndler‐Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J.-P., George, B. M., Lietzenmayer, M., McKenna, K. M., Naik, T. J., McCarty, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710877114 · Cited by 281 · see citing works
From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis
Klei, T. R. L., Meinderts, S. M., van den Berg, T. K., & van Bruggen, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00073 · Cited by 262 · see citing works
Huang, X., Dong, W., Milewska, A., Gołda, A., Qi, Y., Zhu, Q. K., Marasco, W. A., Baric, R. S., Sims, A. M., Pyrć, K., et al. (2015) · Journal of Virology · doi:10.1128/jvi.00854-15 · Cited by 257 · see citing works
Bissonnette, É. Y., Lauzon‐Joset, J., Debley, J. S., & Ziegler, S. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583042 · Cited by 253 · see citing works
Decker, W. K., da Silva, R. F., Sanabria, M. H., Angelo, L. S., Guimarães, F., Burt, B. M., Kheradmand, F., & Paust, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00829 · Cited by 245 · see citing works
Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors
Sloas, D. C., Gill, S. I., & Klichinsky, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.783305 · Cited by 240 · see citing works
He, W., Kapate, N., Shields, C. W., & Mitragotri, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.12.001 · Cited by 237 · see citing works
Hawkins, F. J., Krämer, P., Jacob, A., Driver, I. H., Thomas, D. C., McCauley, K. B., Skvir, N. J., Crane, A. M., Kurmann, A. A., Hollenberg, A. N., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89950 · Cited by 232 · see citing works
Engineering universal cells that evade immune detection
Lanza, R., Russell, D. W., & Nagy, A. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0200-1 · Cited by 230 · see citing works
Non-self recognition by monocytes initiates allograft rejection
Oberbarnscheidt, M. H., Zeng, Q., Li, Q., Dai, H., Williams, A. L., Shlomchik, W. D., Rothstein, D. M., & Lakkis, F. G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74370 · Cited by 222 · see citing works
Macrophage targeting in cancer
Lopez‐Yrigoyen, M., Cassetta, L., & Pollard, J. W. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14377 · Cited by 220 · see citing works
The development and improvement of immunodeficient mice and humanized immune system mouse models
Chen, J., Liao, S., Xiao, Z., Pan, Q., Wang, X., Shen, K., Wang, S., Yang, L., Guo, F., Liu, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1007579 · Cited by 209 · see citing works
The SIRPα–CD47 immune checkpoint in NK cells
Deuse, T., Hu, X., Agbor-Enoh, S. T., Jang, M. K., Alawi, M., Saygı, C., Gravina, A., Tediashvili, G., Nguyen, V. Q., Liu, Y., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200839 · Cited by 208 · see citing works
CD47: role in the immune system and application to cancer therapy
Hayat, S. M. G., Bianconi, V., Pirro, M., Jaafari, M. R., Hatamipour, M., & Sahebkar, A. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00469-5 · Cited by 204 · see citing works
Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials
Egen, J. G., Ouyang, W., & Wu, L. C. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.010 · Cited by 197 · see citing works
A comprehensive review of immune checkpoint inhibitors for cancer treatment
Hossain, M. A. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113365 · Cited by 196 · see citing works
Ramesh, A., Kumar, S., Nandi, D., & Kulkarni, A. A. (2019) · Advanced Materials · doi:10.1002/adma.201904364 · Cited by 191 · see citing works
Is CD47 an innate immune checkpoint for tumor evasion?
Liu, X., Kwon, H., Li, Z., & Fu, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0381-z · Cited by 188 · see citing works
Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles
Zeng, Z., & Pu, K. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202004397 · Cited by 181 · see citing works
Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
Ding, X., Wang, J., Huang, M., Chen, Z., Liu, J., Zhang, Q., Zhang, C., Xiang, Y., Zen, K., & Li, L. (2021) · Nature Communications · doi:10.1038/s41467-021-22301-1 · Cited by 180 · see citing works
Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies
Zhu, S., Yi, M., Wu, Y., Dong, B., & Wu, K. (2021) · Experimental Hematology and Oncology · doi:10.1186/s40164-021-00252-z · Cited by 178 · see citing works
Functions of Thrombospondin-1 in the Tumor Microenvironment
Kaur, S., Bronson, S. M., Pal-Nath, D., Miller, T. W., Soto‐Pantoja, D. R., & Roberts, D. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094570 · Cited by 177 · see citing works
Macrophage phagocytosis after spinal cord injury: when friends become foes
Broeckhoven, J. V., Sommer, D., Dooley, D., Hendrix, S., & Franssen, A. J. P. M. (2021) · Brain · doi:10.1093/brain/awab250 · Cited by 177 · see citing works
CD47 signaling pathways controlling cellular differentiation and responses to stress
Soto‐Pantoja, D. R., Kaur, S., & Roberts, D. D. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1014024 · Cited by 174 · see citing works
Wu, B., Shi, X., Jiang, M., & Liu, H. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01748-4 · Cited by 173 · see citing works
Activation of immune signals during organ transplantation
Li, Q., & Lan, P. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01377-9 · Cited by 173 · see citing works
The CD47-SIRP signalling system: its physiological roles and therapeutic application
Murata, Y., Kotani, T., Ohnishi, H., & Matozaki, T. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu017 · Cited by 171 · see citing works
Thangaraju, K., Neerukonda, S. N., Katneni, U., & Buehler, P. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010153 · Cited by 164 · see citing works
Humanized hemato-lymphoid system mice
Theocharides, A. P. A., Rongvaux, A., Fritsch, K., Flavell, R. A., & Manz, M. G. (2015) · Haematologica · doi:10.3324/haematol.2014.115212 · Cited by 163 · see citing works
Targeting cancer‐related inflammation in the era of immunotherapy
Nakamura, K., & Smyth, M. J. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.126 · Cited by 163 · see citing works
Immune targets in the tumor microenvironment treated by radiotherapy
Ozpiskin, O. M., Zhang, L., & Li, J. J. (2019) · Theranostics · doi:10.7150/thno.32648 · Cited by 163 · see citing works
The promising role of tumor-associated macrophages in the treatment of cancer
Wang, H., Wang, X., Zhang, X., & Xu, W. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101041 · Cited by 157 · see citing works
CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer
Zhao, H., Wang, J., Kong, X., Li, E., Liu, Y., Du, X., Kang, Z., Tang, Y. C., Kuang, Y., Yang, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep29719 · Cited by 152 · see citing works
Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy
Yanagita, T., Murata, Y., Tanaka, D., Motegi, S., Arai, E., Daniwijaya, E. W., Hazama, D., Washio, K., Saito, Y., Kotani, T., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.89140 · Cited by 151 · see citing works
CD47/SIRPα axis: bridging innate and adaptive immunity
van Duijn, A. V. D. P. , van der Burg, S. H., & Scheeren, F. A. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004589 · Cited by 149 · see citing works
Dheilly, E., Moine, V., Broyer, L., Salgado-Pires, S., Johnson, Z., Papaioannou, A., Cons, L., Calloud, S., Majocchi, S., Nelson, R. J., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.11.006 · Cited by 146 · see citing works
Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention
Zhou, X., Liu, X., & Huang, L. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202006220 · Cited by 145 · see citing works
Grabiec, A. M., & Hussell, T. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0555-3 · Cited by 144 · see citing works
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer
Hubert, M., Gobbini, É., Couillault, C., Manh, T. V., Doffin, A., Berthet, J., Rodriguez, C., Ollion, V., Kielbassa, J., Sajous, C., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aav3942 · Cited by 143 · see citing works
Engineered CD47 protects T cells for enhanced antitumour immunity
Yamada‐Hunter, S. A., Theruvath, J. L., McIntosh, B. J., Freitas, K. A., Lin, F. H. S., Radosevich, M., Leruste, A., Dhingra, S., Martínez-Vélez, N., Xu, P., et al. (2024) · Nature · doi:10.1038/s41586-024-07443-8 · Cited by 142 · see citing works
Bian, Z., Shi, L., Guo, Y.-L., Lv, Z., Tang, C., Niu, S., Tremblay, A., Venkataramani, M., Culpepper, C. D., Li, L., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521069113 · Cited by 139 · see citing works
Localized CD47 blockade enhances immunotherapy for murine melanoma
Ingram, J. R., Blomberg, O. S., Sockolosky, J. T., Ali, L. R., Schmidt, F. I., Pishesha, N., Espinosa, C. A., Dougan, S. K., García, K. C., Ploegh, H. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710776114 · Cited by 138 · see citing works
Exploring the Emerging Role of the Gut Microbiota and Tumor Microenvironment in Cancer Immunotherapy
Qiu, Q., Lin, Y., Ma, Y., Li, X., Liang, J. B., Chen, Z., Liu, K., Huang, Y., Luo, H., Huang, R., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.612202 · Cited by 137 · see citing works
Lian, S., Xie, R., Ye, Y., Xie, X., Li, S., Lu, Y., Li, B., Cheng, Y., Katanaev, V. L., & Jia, L. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.018 · Cited by 137 · see citing works
Tumor-associated macrophages: A promising target for a cancer immunotherapeutic strategy
Zhang, S., Song, X., Yang, L., Ye, L., Zhou, Q., & Yang, W.-B. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105111 · Cited by 135 · see citing works
Tumor-Associated Macrophages: A Potential Target for Cancer Therapy
Tan, Y., Wang, M., Zhang, Y., Ge, S., Zhong, F., Xia, G., & Sun, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.693517 · Cited by 134 · see citing works
Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts
Dai, H., Friday, A. J., Abou‐Daya, K. I., Williams, A. L., Mortin-Toth, S. M., Nicotra, M. L., Rothstein, D. M., Shlomchik, W. D., Matozaki, T., Isenberg, J. S., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aam6202 · Cited by 132 · see citing works
Cell membrane camouflaged nanoparticles: a new biomimetic platform for cancer photothermal therapy
Wu, M., Le, W., Mei, T., Wang, Y., Chen, B., Liu, Z., & Xue, C. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s200284 · Cited by 130 · see citing works
de Charette, M., & Houot, R. (2018) · Haematologica · doi:10.3324/haematol.2017.184192 · Cited by 129 · see citing works
Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer
Alhosin, M., Omran, Z., Zamzami, M. A., Al-Malki, A. L., Choudhry, H., Mousli, M., & Bronner, C. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0453-5 · Cited by 126 · see citing works
Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion
Liu, X., Liu, L., Ren, Z., Yang, K., Xu, H., Luan, Y., Fu, K., Guo, J., Peng, H., Zhu, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.062 · Cited by 126 · see citing works
Qadri, S. M., Bissinger, R., Solh, Z., & Oldenborg, P. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.06.001 · Cited by 125 · see citing works
Wang, H., Sun, Y., Zhou, X., Chen, C., Jiao, L., Li, W., Gou, S., Li, Y., Du, J., Chen, G., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000905 · Cited by 123 · see citing works
Targeting tumor-associated macrophages for cancer immunotherapy
Shu, Y., & Cheng, P. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188434 · Cited by 122 · see citing works
Regulation of CD47 expression in cancer cells
Huang, C.-Y., Ye, Z.-H., Huang, M., & Lu, J. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100862 · Cited by 119 · see citing works
Nanomedicine in Cancer Therapeutics: Current Perspectives from Bench to Bedside
Abdullah, K. M., Sharma, G., Singh, A. P., & Siddiqui, J. A. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02368-w · Cited by 117 · see citing works
Buatois, V., Johnson, Z., Salgado-Pires, S., Papaioannou, A., Hatterer, E., Chauchet, X., Richard, F., Barba, L., Daubeuf, B., Cons, L., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-1095 · Cited by 115 · see citing works
Jalil, A. R., Andrechak, J. C., & Discher, D. E. (2020) · Antibody Therapeutics · doi:10.1093/abt/tbaa006 · Cited by 115 · see citing works
Wang, Y., Ni, H., Zhou, S., He, K., Gao, Y., Wu, W., Wu, M. H., Wu, Z., Qiu, X., Zhou, Y., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02679-5 · Cited by 115 · see citing works
Lv, Z., Bian, Z., Shi, L., Niu, S., Ha, B., Tremblay, A., Li, L., Zhang, X., Paluszynski, J. P., Liu, M., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401719 · Cited by 114 · see citing works
Cho, E., Nam, G., Hong, Y., Kim, Y. K., Kim, D., Yang, Y., & Kim, I. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.04.037 · Cited by 114 · see citing works
CRISPRed Macrophages for Cell-Based Cancer Immunotherapy
Ray, M., Lee, Y.-W., Hardie, J. M., Mout, R., Tonga, G. Y., Farkas, M. E., & Rotello, V. M. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00768 · Cited by 113 · see citing works
Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications
Zhang, X., Xu, Q., Zi, Z., Liu, Z., Wan, C., Crisman, L., Shen, J., & Liu, X. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.11.007 · Cited by 113 · see citing works
The Role of Peritoneal Macrophages in Endometriosis
Ramírez-Pavez, T. N., Martinez‐Esparza, M., Ruiz‐Alcaraz, A. J., Marín‐Sánchez, P., Machado‐Linde, F., & García–Peñarrubia, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910792 · Cited by 113 · see citing works
Yi, T., Li, J., Chen, H., Wu, J., An, J., Xu, Y., Hu, Y., Lowell, C. A., & Cyster, J. G. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.021 · Cited by 111 · see citing works
From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins
Kourtzelis, I., Mitroulis, I., von Renesse, J., Hajishengallis, G., & Chavakis, T. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0117-024r · Cited by 110 · see citing works
- Authors
- Barclay, A. N., & van den Berg, T. K.
- Affiliations
- University of Oxford (GB)
- Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands;
- ORCID
- Barclay, A. Neil
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2014-03-21
- Volume
- 32
- Issue
- 1
- Pages
- 25-50
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2139418176
- Cited by
- 841
- References
- 155
- Citations by year
- 2026: 63 · 2025: 107 · 2024: 108 · 2023: 84 · 2022: 77 · 2021: 89 · 2020: 89 · 2019: 51 · 2018: 44 · 2017: 60 · 2016: 32 · 2015: 26 · 2014: 11
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- CD47, SIRPα, don't eat me signal, phagocytosis, immune evasion, autoimmunity, host defense, cancer immunotherapy, inflammation, xenotransplantation, graft survival, receptor evolution
- MeSH terms
- Animals, Antigens, Differentiation, Autoimmune Diseases, Dendritic Cells, Multigene Family, Hematologic Diseases, Humans, Neoplasms, Phagocytosis, Protein Binding, Receptors, Immunologic, T-Lymphocytes, Signal Transduction, CD47 Antigen, Immunological Synapses, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
