The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance to Listeria monocytogenes Challenge
Abstract
Vertebrates have evolved innate immune defense mechanisms that recognize and respond to structural patterns that are specific to microbial molecules. One such pattern recognition system is based on unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs); these motifs are common in bacterial DNA but are under-represented (“CpG suppression”) and methylated in vertebrate DNA. Mice that are injected with bacterial DNA or synthetic oligodeoxynucleotides (ODNs) containing CpG motifs respond with a rapid production of IL-12 and IFN-γ. The serum levels of IL-12 were increased for at least 8 days after a single injection of CpG ODNs, but IFN-γ levels returned to baseline within 24 h. This Th1-like cytokine response to CpG motifs induces a state of resistance to infection by Listeria monocytogenes in susceptible specific pathogen-free BALB/c mice. Resistance developed within 48 h of pretreatment with CpG ODNs, persisted for at least 2 wk, and was dependent upon IFN-γ secretion. These data support the hypothesis that CpG DNA motifs are a “danger signal” that activates protective innate immune defenses and may have therapeutic potential.
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Cites
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
Self-citationImmune Response in Mice that Lack the Interferon-γ Receptor
Huang, S., Hendriks, W., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilček, J., Zinkernagel, R. M., & Aguet, M. (1993) · Science · doi:10.1126/science.8456301 · Cited by 1,548
Klinman, D. M., Yi, A. K., Beaucage, S. L., Conover, J., & Krieg, A. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2879 · Cited by 1,477
Self-citationRothe, J., Lesslauer, W., Lötscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R., Steinmetz, M., & Bluethmann, H. (1993) · Nature · doi:10.1038/364798a0 · Cited by 1,245
Pasparakis, M., Alexopoulou, L., Episkopou, V, & Kollias, G. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.4.1397 · Cited by 1,160
Immunity to Intracellular Bacteria
Kaufmann, S. H. E. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001021 · Cited by 1,059
Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization
Sato, Y., Roman, M., Tighe, H., Lee, D., Corr, M., Nguyen, M.-D., Silverman, G. J., Lotz, M., Carson, D. A., & Raz, E. (1996) · Science · doi:10.1126/science.273.5273.352 · Cited by 1,058
CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity
Chu, R. S., Targoni, O. S., Krieg, A. M., Lehmann, P. V., & Harding, C. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.10.1623 · Cited by 1,002
Self-citationImmunostimulatory DNA sequences function as T helper-1-promoting adjuvants
Roman, M., Martin-Orozco, E., Goodman, J. S., Nguyen, M.-D., Sato, Y., Ronaghy, A., Kornbluth, R. S., Richman, D. D., Carson, D. A., & Raz, E. (1997) · Nature Medicine · doi:10.1038/nm0897-849 · Cited by 908
Tripp, C. S., Wolf, S. F., & Unanue, E. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3725 · Cited by 776
Cited by
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells
Hartmann, G., & Krieg, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.944 · Cited by 605
Self-citationNucleic acid recognition by the innate immune system
Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577
Levin, A. A. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00140-2 · Cited by 438
Bacterial CpG DNA Activates Immune Cells to Signal Infectious Danger
Wagner, H. (1999) · Advances in Immunology · doi:10.1016/s0065-2776(08)60790-7 · Cited by 314
Metadata
- Authors
- Krieg, A. M., Love-Homan, L., Yi, A.-K., & Harty, J. T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-09-01
- Volume
- 161
- Issue
- 5
- Pages
- 2428-2434
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1591928190
- Cited by
- 379
- References
- 31
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance to Listeria monocytogenes Challenge. https://app.cochat.ai/papers/10.4049/jimmunol.161.5.2428
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- Krieg, A. M., Love-Homan, L., Yi, A.-K., & Harty, J. T. (1998). CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance to Listeria monocytogenes Challenge. The Journal of Immunology. https://doi.org/10.4049/jimmunol.161.5.2428
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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