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Cited by 371

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation

Kaliński, Paweł, Schuitemaker, Joost H N, Hilkens, Catharien M U, Kapsenberg, Martien L·1998·The Journal of Immunology
DOI 10.4049/jimmunol.161.6.2804
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Abstract

Activation of immature dendritic cells (DC) in peripheral tissues induces their migration to lymph nodes and their maturation into CD83+ DC, which are able to prime naive T cells. The inflammatory cytokines IL-1β and TNF-α induce mature DC, which can secrete IL-12 and promote the development of Th0/Th1-biased cells. DC maturation factors with a Th2-promoting function have not been described. Here we show that PGE2, although it does not induce final DC maturation by itself, synergizes with IL-1β and TNF-α, and allows their effectiveness at 100-fold lower concentrations. While being phenotypically identical with the DC matured in the presence of high concentrations of IL-1β and TNF-α alone, DC matured in the additional presence of PGE2 show impaired IL-12 production and bias naive Th cell development toward the Th2. The ability of DC to produce IL-12 is also suppressed by IL-10, which in contrast to PGE2, inhibits their maturation. The differences in the ability to produce IL-12, established during the final DC maturation, are stable after the removal of modulatory factors. Importantly, fully mature DC become unsusceptible to PGE2 and IL-10. This indicates that the levels of IL-12 production in vivo, in mature DC interacting with Th cells within the lymph nodes, are mainly predetermined at the stage of immature DC in peripheral tissues. These data imply that the character of pathogen-induced local inflammatory reaction can “instruct” local DC to initiate Th1 or Th2-biased responses.

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Metadata

Authors
Kaliński, P., Schuitemaker, J. H. N., Hilkens, C. M. U., & Kapsenberg, M. L.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
1998-09
Volume
161
Issue
6
Pages
2804-2809
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.161.6.2804
OpenAlex
W2123190790
Cited by
371
References
28
FWCI
8.72
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation. https://app.cochat.ai/papers/10.4049/jimmunol.161.6.2804
The paper
Kaliński, P., Schuitemaker, J. H. N., Hilkens, C. M. U., & Kapsenberg, M. L. (1998). Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.161.6.2804

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.