Chemokines in cancer

Vicari, Alain P; Caux, Christophe

doi:10.1016/s1359-6101(01)00033-8

Cited by 352Chemokine receptors and signalingAngiogenesis and VEGF in CancerImmune cells in cancer

Chemokines in cancer

Vicari, Alain P, Caux, Christophe·2002·Cytokine & Growth Factor Reviews

DOI 10.1016/s1359-6101(01)00033-8

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Abstract

Chemokines participate, by regulating cell trafficking and controlling angiogenesis, in the host response during infection and inflammation. Most of these mechanisms are also operating in cancer. The stimulation of angiogenesis and tumor growth--directly or indirectly through the recruitment of tumor-associated macrophages--are typical situations where chemokines promote tumor development. On the other hand, chemokines could be used to the benefit of cancer patients as they act in the recruitment of dendritic cells (DC) or/and effector cells or for their angiostatic properties. However, chemokine-mediated recruitment of immature DC within tumors, due to factors produced by the tumor milieu, could lead to the induction of immune tolerance and, therefore, novel strategies to eradicate tumors based on chemokines should attempt to avoid this risk.

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From Inflammation and cancer (2002) · cites this paper as [44]

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CX3CR1 Is Expressed by Prostate Epithelial Cells and Androgens Regulate the Levels of CX3CL1/Fractalkine in the Bone Marrow: Potential Role in Prostate Cancer Bone Tropism
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Tumor Promotion by Tumor-Associated Macrophages
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Molecular Imaging of Chemokine Receptor CXCR4
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Intratumoral CC chemokine ligand 5 overexpression delays tumor growth and increases tumor cell infiltration
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Migration of cytotoxic T lymphocytes toward melanoma cells in three‐dimensional organotypic culture is dependent on CCL2 and CCR4
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CXC chemokines and chemokine receptors in gastric cancer: From basic findings towards therapeutic targeting
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Anti-Inflammatory Agents as Cancer Therapeutics
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Chemokine Decoy Receptor D6 Plays a Negative Role in Human Breast Cancer
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Defective antitumor responses in CX3CR1‐deficient mice
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The chemokine network: A target in cancer biology?
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Transforming Growth Factor-β Receptor Blockade Augments the Effectiveness of Adoptive T-Cell Therapy of Established Solid Cancers
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Systemic Blockade of Transforming Growth Factor-β Signaling Augments the Efficacy of Immunogene Therapy
Kim, S., Buchlis, G., Fridlender, Z. G., Sun, J., Kapoor, V., Cheng, G., Haas, A. R., Cheung, H. K., Zhang, X., Corbley, M. J., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1494 · Cited by 84 · see citing works
Materials for Improving Immune Cell Transfection
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Macrophages and tumor angiogenesis
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An Essential Role of Th1 Responses and Interferon-gamma in Infection-Mediated Suppression of Neoplastic Growth
Rankin, E. B., & Yu, D. (2003) · Cancer Biology & Therapy · doi:10.4161/cbt.2.6.557 · Cited by 82 · see citing works
Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer
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Chemokines: key players in cancer
Arya, M., PATEL, H. R. H., & Williamson, M. P. (2003) · Current Medical Research and Opinion · doi:10.1185/030079903125002216 · Cited by 80 · see citing works
G protein-coupled receptors in natural killer cells
Maghazachi, A. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103019 · Cited by 80 · see citing works
Tissue Microenvironment Modulates CXCR4 Expression and Tumor Metastasis in Neuroblastoma
Zhang, L., Yeger, H., Das, B., Irwin, M. S., & Baruchel, S. (2007) · Neoplasia · doi:10.1593/neo.06670 · Cited by 79 · see citing works
CXCR4 expression reflects tumor progression and regulates motility of bladder cancer cells
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In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis
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Immunohistological characterisation of tumour infiltrating lymphocytes in melanocytic skin lesions
Hussein, M. R., Elsers, D., Fadel, S. A., & Omar, A.-E. M. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.028860 · Cited by 79 · see citing works
The relevance of cytokines for development of protective immunity and rational design of vaccines
Chabalgoity, J. A., Baz, A., Rial, A., & Grille, S. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.01.016 · Cited by 78 · see citing works
Up‐regulation of the interferon γ (IFN‐γ)‐inducible chemokines IFN‐inducible T‐cell α chemoattractant and monokine induced by IFN‐γ and of their receptor CXC receptor 3 in human renal cell carcinoma
Suyama, T., Furuya, M., Nishiyama, M., Kasuya, Y., Kimura, S., Ichikawa, T., Ueda, T., Nikaido, T., Itô, H., & Ishikura, H. (2004) · Cancer · doi:10.1002/cncr.20747 · Cited by 78 · see citing works
Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming
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Inflammation-Induced Hepatocellular Carcinoma Is Dependent on Ccr5 in Mice
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PET imaging of CXCR4 using copper-64 labeled peptide antagonist
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Tumor-Associated Macrophages and Dendritic Cells as Prototypic Type II Polarized Myeloid Populations
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Authors: Vicari, A. P., & Caux, C.
Corresponding author: Vicari, Alain P
ORCID: Caux, Christophe
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2002-04
Volume: 13
Issue: 2
Pages: 143-154
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/s1359-6101(01)00033-8
OpenAlex: W2092021793
Cited by: 351
References: 173
Citations by year: 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 14 · 2019: 11 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 20 · 2013: 18 · 2012: 21
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: chemokines, cancer, angiogenesis, tumor growth, tumor-associated macrophages, dendritic cell recruitment, immune tolerance, tumor microenvironment, cell trafficking
MeSH terms: Animals, Dendritic Cells, Humans, Killer Cells, Natural, Leukocytes, Models, Biological, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, T-Lymphocytes, Chemokines

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