IFN-γ Is Required for IL-12 Responsiveness in Mice with Candida albicans Infection
Abstract
To elucidate the role of IFN-γ in antifungal CD4+ Th-dependent immunity, 129/Sv/Ev mice deficient for IFN-γ receptor (IFN-γR−/−) were assessed for susceptibility to gastrointestinal or systemic Candida albicans infection and for parameters of innate and adaptive T helper immunity. IFN-γR−/− mice failed to mount protective Th1-mediated acquired immunity upon mucosal immunization or in response to a live vaccine strain of the yeast. The impaired Th1-mediated resistance correlated with defective IL-12 responsiveness, but not IL-12 production, and occurred in the presence of an increased innate antifungal resistance. The development of nonprotective Th2 responses was observed in IFN-γR−/− mice upon mucosal infection and subsequent reinfection. However, under experimental conditions of Th2 cell activation, the occurrence of Th2 cell responses was similar in IFN-γR−/− and in IFN-γR+/+ mice. These results indicate the complex immunoregulatory role of IFN-γ in the induction of mucosal and nonmucosal anticandidal Th cell responses; IFN-γ is not essential for the occurrence of Th2 responses but is required for development of IL-12-dependent protective Th1-dependent immunity.
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Th1 cells protect the host against fungal pathogens, including C. albicans.
“Th1 cells protect the host against fungal pathogens, including C. albicans [18,19].”
From The Emerging Fungal Pathogen Candida auris Induces IFNγ to Colonize the Skin (2025) · cites this paper as [19]
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- Authors
- Cenci, E., Mencacci, A., Del Sero, G., Fé d’Ostiani, C., Mosci, P., Bacci, A., Montagnoli, C., Kopf, M., & Romani, L.
- Affiliations
- University of Perugia (IT)
- Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia , Perugia ,
- Basel Institute of Immunology , Basel ,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-10-01
- Volume
- 161
- Issue
- 7
- Pages
- 3543-3550
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313310013
- Cited by
- 67
- References
- 57
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- interferon-gamma, IL-12, Candida albicans, antifungal immunity, Th1 cells, Th2 cells, mucosal immunity, innate immunity, CD4+ T cells, fungal infection susceptibility, reinfection
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