Cited by 67Antifungal resistance and susceptibilityT-cell and B-cell ImmunologyFungal and yeast genetics research

IFN-γ Is Required for IL-12 Responsiveness in Mice with Candida albicans Infection

Cenci, Elio, Mencacci, Antonella, Del Sero, Giuseppe, Fé d’Ostiani, Cristiana, Mosci, Paolo, Bacci, Angela, Montagnoli, Claudia, Kopf, Manfred +1 more·1998·The Journal of Immunology

Abstract

To elucidate the role of IFN-γ in antifungal CD4+ Th-dependent immunity, 129/Sv/Ev mice deficient for IFN-γ receptor (IFN-γR−/−) were assessed for susceptibility to gastrointestinal or systemic Candida albicans infection and for parameters of innate and adaptive T helper immunity. IFN-γR−/− mice failed to mount protective Th1-mediated acquired immunity upon mucosal immunization or in response to a live vaccine strain of the yeast. The impaired Th1-mediated resistance correlated with defective IL-12 responsiveness, but not IL-12 production, and occurred in the presence of an increased innate antifungal resistance. The development of nonprotective Th2 responses was observed in IFN-γR−/− mice upon mucosal infection and subsequent reinfection. However, under experimental conditions of Th2 cell activation, the occurrence of Th2 cell responses was similar in IFN-γR−/− and in IFN-γR+/+ mice. These results indicate the complex immunoregulatory role of IFN-γ in the induction of mucosal and nonmucosal anticandidal Th cell responses; IFN-γ is not essential for the occurrence of Th2 responses but is required for development of IL-12-dependent protective Th1-dependent immunity.

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Crossref · 10.4049/jimmunol.161.7.3543

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Authors
Cenci, E., Mencacci, A., Del Sero, G., Fé d’Ostiani, C., Mosci, P., Bacci, A., Montagnoli, C., Kopf, M., & Romani, L.
Affiliations
  • University of Perugia (IT)
  • Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia , Perugia ,
  • Basel Institute of Immunology , Basel ,
Venue
The Journal of Immunology
Published
1998-10-01
Volume
161
Issue
7
Pages
3543-3550
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W4313310013
Cited by
67
References
57
Citations by year
2026: 1 · 2025: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 1
FWCI
3.61
Type
journal article
Language
en
Open access
closed
Locations
The Journal of Immunology (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
interferon-gamma, IL-12, Candida albicans, antifungal immunity, Th1 cells, Th2 cells, mucosal immunity, innate immunity, CD4+ T cells, fungal infection susceptibility, reinfection

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