The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes
Abstract
Human monocyte/macrophages (Mφ) exposed to nonparticulate stimuli can express cell surface Fas ligand (FasL) and release active soluble FasL (sFasL). We now report that monocyte/Mφ-ingesting opsonized zymosan released sFasL and conditioned supernatants so that these triggered Fas-mediated apoptosis of “bystander” monocytes and FasL-negative neutrophils. Furthermore, identical results were seen with Mφ taking up apoptotic neutrophils, whereas medium conditioned by Mφ phagocytizing latex beads had no proapoptotic effects upon neutrophils despite the presence of sFasL. These data suggest the hitherto unrecognized existence of a feedback loop requiring soluble factors in addition to sFasL that may promote resolution of inflammation-phagocytic clearance of apoptotic cells leading to Fas-mediated killing of bystander leukocytes by phagocytizing macrophages.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,385
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 1×
“Indeed, our data support reports that Mf-ingesting apoptotic cells may generate antiinflammatory responses such as IL-10 release (33, 34), because M f-derived FasL might be expected to promote “antiinflammatory” elimination of other leukocytes, including eosinophils, monocytes, and activated T cells (8, 11, 13).”
Immunosuppressive effects of apoptotic cells
Voll, R. E., Herrmann, M., Roth, E. A., Stach, C., Kalden, J. R., & Girkontaite, I. (1997) · Nature · doi:10.1038/37022 · Cited by 1,787
Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536
Self-citationHaslett, C., Guthrie, L. A., Kopaniak, M. M., Johnston, R. B., & Henson, P. M. (1985) · PubMed Central · Cited by 779
Lee, A., Whyte, M. K. B., & Haslett, C. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.4.283 · Cited by 714
Downregulation of Fas ligand by shedding
Tanaka, M., Itai, T., Adachi, M., & Nagata, S. (1998) · Nature Medicine · doi:10.1038/nm0198-031 · Cited by 669
Coxon, A., Rieu, P., Barkalow, F. J., Askari, S., Sharpe, A. H., von Andrian, U. H., Arnaout, M. A., & Mayadas, T. N. (1996) · Immunity · doi:10.1016/s1074-7613(00)80278-2 · Cited by 627
Liles, W. C., Kiener, P. A., Ledbetter, J. A., Aruffo, A., & Klebanoff, S. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.2.429 · Cited by 557
Cited by
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
Self-citationClearance of apoptotic and necrotic cells and its immunological consequences
Krysko, D. V., D’Herde, K., & Vandenabeele, P. (2006) · Apoptosis · doi:10.1007/s10495-006-9527-8 · Cited by 316
Macrophages inhibit neovascularization in a murine model of age-related macular degeneration
Apte, R. S., Richter, J., Herndon, J., & Ferguson, T. A. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030310 · Cited by 249
Role of neutrophils in innate immunity: A systems biology-level approach
Kobayashi, S. D., & DeLeo, F. R. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.32 · Cited by 259
Allen, L., Dockrell, D. H., Pattery, T., Lee, D. G., Cornelis, P., Hellewell, P. G., & Whyte, M. K. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3643 · Cited by 257
Metadata
- Authors
- Brown, S. B., & Savill, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 162
- Issue
- 1
- Pages
- 480-485
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1681184579
- Cited by
- 276
- References
- 34
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes. https://app.cochat.ai/papers/10.4049/jimmunol.162.1.480
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- Brown, S. B., & Savill, J. (1999). Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.1.480
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
