The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation
Abstract
CTLA-4 engagement by mAbs inhibits, while CD28 enhances, IL-2 production and proliferation upon T cell activation. Here, we have analyzed the mechanisms involved in CTLA-4-mediated inhibition of T cell activation of naive CD4+ T cells using Ab cross-linking. CTLA-4 ligation inhibited CD3/CD28-induced IL-2 mRNA accumulation by inhibiting IL-2 transcription, which appears to be mediated in part through decreasing NF-AT accumulation in the nuclei. However, CTLA-4 ligation did not appear to affect the CD28-mediated stabilization of IL-2 mRNA. Further, CTLA-4 engagement inhibited progression through the cell cycle by inhibiting the production of cyclin D3, cyclin-dependent kinase (cdk)4, and cdk6 when the T cells were stimulated with anti-CD3/CD28 and with anti-CD3 alone. These results indicate that CTLA-4 signaling inhibits events early in T cell activation both at IL-2 transcription and at the level of IL-2-independent events of the cell cycle, and does not simply oppose CD28-mediated costimulation.
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Citations
Cites
Enhancement of Antitumor Immunity by CTLA-4 Blockade
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Self-citationInhibitors of mammalian G1 cyclin-dependent kinases.
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Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
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“CD4(1) lymph node T cells (LNT) were stimulated with Ab-coated beads, and proliferation assays were performed as previously described (8, 17).”
BackgroundMethodInfluentialSelf-citationCTLA-4 can function as a negative regulator of T cell activation
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The Role of the CD28 Receptor During T Cell Responses to Antigen
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Self-citationJNK is involved in signal integration during costimulation of T lymphocytes
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Cited by
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
Wei, S. C., Duffy, C. R., & Allison, J. P. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0367 · Cited by 3,088
Self-citationCheckpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Gubin, M. M., Zhang, X., Schuster, H., Caron, E., Ward, J. P., Noguchi, T., Ivanova, Y., Hundal, J., Arthur, C. D., Krebber, W.-J., et al. (2014) · Nature · doi:10.1038/nature13988 · Cited by 1,974
“…8,9,21,22 ; (b) whereas α CTLA-4 treatment eliminates Tregs, promotes T cell priming, and renders the host more susceptible to autoimmunity 13,22,23 ; α PD-1 promotes T cell activation acting as a rheostat of immune effector function 9,22,24,25 ; and (c) dual blockade of CTLA-4 and PD-1 is…”
Self-citationPhan, G. Q., Yang, J. C., Sherry, R. M., Hwu, P., Topalian, S. L., Schwartzentruber, D. J., Restifo, N. P., Haworth, L. R., Seipp, C. A., Freezer, L. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533209100 · Cited by 1,575
Self-citationThe CD28 Signaling Pathway Regulates Glucose Metabolism
Frauwirth, K. A., Riley, J. L., Harris, M. H., Parry, R. V., Rathmell, J. C., Plas, D. R., Elstrom, R. L., June, C. H., & Thompson, C. B. (2002) · Immunity · doi:10.1016/s1074-7613(02)00323-0 · Cited by 1,475
Attia, P., Phan, G. Q., Maker, A. V., Robinson, M. R., Quezado, M. M., Yang, J. C., Sherry, R. M., Topalian, S. L., Kammula, U. S., Royal, R. E., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.205 · Cited by 1,012
Metadata
- Authors
- Brunner, M. C., Chambers, C. A., Chan, F. K.-M., Hanke, J., Winoto, A., & Allison, J. P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-05
- Volume
- 162
- Issue
- 10
- Pages
- 5813-5820
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1542616270
- Cited by
- 419
- References
- 72
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brunner, M. C., Chambers, C. A., Chan, F. K.-M., Hanke, J., Winoto, A., & Allison, J. P. (1999). CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.10.5813
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
