The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System
Abstract
Mammalian 60-kDa heat-shock protein (hsp60) is a key target of T cell and Ab responses in chronic inflammation or atherosclerosis. We show in this study that human hsp60 is also an Ag recognized by cells of the innate immune system, such as macrophages. Both mouse and human macrophages respond to contact with exogenous human hsp60 with rapid release of TNF-α; mouse macrophages in addition produce nitric oxide. The proinflammatory macrophage response is hsp60 dose dependent and similar in kinetics and extent to LPS stimulation. Human hsp60 was found to synergize with IFN-γ in its proinflammatory activity. Finally, human hsp60 induces gene expression of the Th1-promoting cytokines IL-12 and IL-15. These findings identify autologous hsp60 as a danger signal for the innate immune system, with important implications for a role of local hsp60 expression/release in chronic Th1-dependent tissue inflammation.
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Cites
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Cited by
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
Danger signals: SOS to the immune system
Gallucci, S., & Matzinger, P. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00191-6 · Cited by 1,204
Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
Bogdan, C., Röllinghoff, M., & Diefenbach, A. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00052-7 · Cited by 939
The Inflammatory Response to Cell Death
Rock, K. L., & Kono, H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151456 · Cited by 912
Type 1/Type 2 Immunity in Infectious Diseases
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Metadata
- Authors
- Chen, W., Syldath, U., Bellmann, K., Burkart, V., & Kolb, H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03
- Volume
- 162
- Issue
- 6
- Pages
- 3212-3219
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1518351006
- Cited by
- 468
- References
- 42
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, W., Syldath, U., Bellmann, K., Burkart, V., & Kolb, H. (1999). Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.6.3212
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
