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A Novel Receptor Tyrosine Kinase, Mer, Inhibits TNF-α Production and Lipopolysaccharide-Induced Endotoxic Shock
Open accessAbstract
Abstract The regulation of monocyte function and the inhibition of TNF-α production during bacterial sepsis are critical in attenuating adverse host responses to endotoxemia. To study the function of a novel receptor tyrosine kinase, mer, that is expressed in monocytes, we generated mice (merkd) that lack the signaling tyrosine kinase domain. Upon LPS challenge, merkd animals died of endotoxic shock (15/17, 88.2%), whereas control wild-type mice survived (1/15, 6.7% died). Susceptible merkd mice exhibited edema, leukocyte infiltration, and signs of endotoxic shock that correlated with higher levels of TNF-α found in the serum of merkd mice as compared with wild-type control animals. Death due to LPS-induced endotoxic shock in merkd mice was blocked by administration of anti-TNF-α Ab, suggesting that overproduction of this cytokine was principally responsible for the heightened suseptibility. The increase in TNF-α production appeared to be the result of a substantial increase in the LPS-dependent activation of NF-κB nuclear translocation resulting in greater TNF-α production by macrophages from merkd mice. Thus, Mer receptor tyrosine kinase signaling participates in a novel inhibitory pathway in macrophages important for regulating TNF-α secretion and attenuating endotoxic shock.
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“Consistent with our findings, Camenish et al. showed that Mertk knockdown was associated with an enhanced Tnf response and exacerbated response to endotoxemia [32].”
From Multifaceted response of microglia in the cuprizone model of demyelination (2026) · cites this paper as [32]
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“Similar effects were observed in response to dying cells in macrophages lacking Rac1 or the efferocytosis receptors merTK and TIM4 (Cai et al., 2018; Camenisch et al., 1999; Martinez et al., 2011; Scott et al., 2001; Thorp et al., 2008), consistent with this idea.”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Camenisch et al., 1999
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Metadata
- Authors
- Camenisch, T. D., Koller, B. H., Earp, H. S., & Matsushima, G. K.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03
- Volume
- 162
- Issue
- 6
- Pages
- 3498-3503
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313344687
- Cited by
- 290
- References
- 31
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 21 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 18 · 2019: 17 · 2018: 16 · 2017: 17 · 2016: 13 · 2015: 13 · 2014: 12 · 2013: 13 · 2012: 5
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- Funders
- University of North Carolina at Chapel Hill
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- Mer receptor tyrosine kinase, TNF-alpha production, endotoxic shock, lipopolysaccharide, endotoxemia, sepsis, monocytes, macrophages, NF-κB nuclear translocation, anti-TNF-alpha antibody, receptor signaling
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