Phagocytosis and clearance of apoptotic cells is mediated by MER

Scott, Rona S.; McMahon, Eileen J.; Pop, Shannon M.; Reap, Elizabeth A.; Caricchio, Roberto; Cohen, Philip L.; Earp, H. Shelton; Matsushima, Glenn K.

doi:10.1038/35075603

Cited by 1,215Phagocytosis and Immune RegulationSystemic Lupus Erythematosus ResearchCell death mechanisms and regulation

Phagocytosis and clearance of apoptotic cells is mediated by MER

Scott, Rona S., McMahon, Eileen J., Pop, Shannon M., Reap, Elizabeth A., Caricchio, Roberto, Cohen, Philip L., Earp, H. Shelton, Matsushima, Glenn K.·2001·Nature

DOI 10.1038/35075603

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Abstract

Apoptosis is fundamental to the development and maintenance of animal tissues and the immune system. Rapid clearance of apoptotic cells by macrophages is important to inhibit inflammation and autoimmune responses against intracellular antigens. Here we report a new function for Mer, a member of the Axl/Mer/Tyro3 receptor tyrosine kinase family. mer(kd) mice with a cytoplasmic truncation of Mer had macrophages deficient in the clearance of apoptotic thymocytes. This was corrected in chimaeric mice reconstituted with bone marrow from wild-type animals. Primary macrophages isolated from mer(kd) mice showed that the phagocytic deficiency was restricted to apoptotic cells and was independent of Fc receptor-mediated phagocytosis or ingestion of other particles. The inability to clear apoptotic cells adequately may be linked to an increased number of nuclear autoantibodies in mer(kd) mice. Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus.

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MERTK plays a key role in a variety of phagocytic events, including microglial phagocytosis, macrophage phagocytosis, and phagocytosis by Sertoli cells.
“In general, MERTK plays a key role in a variety of phagocytic events, such as microglial phagocytosis to mediate synaptic pruning (Chung et al., 2013), macrophage phagocytosis to remove apoptotic immune cells (Scott et al., 2001), and phagocytosis of apoptotic germ cells and the residual body from maturing sperm by Sertoli cells in the testes (Breucker et al., 1985).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Scott et al., 2001

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Authors: Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K.
Affiliations: University of North Carolina at Chapel Hill (US)
AlphaVax (United States) (US)
University of Pennsylvania (US)
UNC Lineberger Comprehensive Cancer Center (US)
Corresponding author: Matsushima, Glenn K.
ORCID: Scott, Rona S.
Caricchio, Roberto
Cohen, Philip L.
Earp, H. Shelton
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-05
Volume: 411
Issue: 6834
Pages: 207-211
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35075603
OpenAlex: W2011617127
Cited by: 1,215
References: 31
Citations by year: 2026: 27 · 2025: 32 · 2024: 61 · 2023: 44 · 2022: 29 · 2021: 39 · 2020: 61 · 2019: 50 · 2018: 40 · 2017: 50 · 2016: 39 · 2015: 44 · 2014: 60 · 2013: 51 · 2012: 45
FWCI: 21.24
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Research Councils UK
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: Mer receptor tyrosine kinase, efferocytosis, phagocytosis, macrophages, systemic lupus erythematosus, autoimmunity, inflammation, thymocytes
MeSH terms: c-Mer Tyrosine Kinase, Animals, Antibodies, Antinuclear, Cell Adhesion, Cells, Cultured, Crosses, Genetic, Cytochalasin B, Dexamethasone, Female, Flow Cytometry, Immunohistochemistry, Listeria monocytogenes, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Microscopy, Electron, Scanning, Microspheres, Mutation, Phagocytosis, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Radiation Chimera, Receptors, Fc, Thymus Gland, Bone Marrow Transplantation, Apoptosis, Macrophages, Peritoneal, Receptor Protein-Tyrosine Kinases, Mice

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Phagocytosis and clearance of apoptotic cells is mediated by MER

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