The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells
Abstract
Immunization with heat shock proteins (HSPs) induces Ag-specific CTL responses. The specificity of the immune response is based on peptides associated with HSPs. To investigate how exogenous HSP/peptide complexes gain access to the MHC class I-restricted Ag presentation pathway, we incubated the monocytic cell line P388D1 and the dendritic cell line D2SC/1 with gold-labeled HSPs gp96 and HSC70. We show that HSPs bind specifically to the surface of these APCs and are internalized spontaneously by receptor-mediated endocytosis, demonstrating the existence of specific receptors for HSPs on these cells. In addition, we observe colocalization of internalized HSPs and surface MHC class I molecules in early and late endosomal structures. These findings provide possible explanations for the immunogenicity of HSP/peptide complexes and for the transfer of HSP-associated peptides onto MHC class I molecules.
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Cites
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A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides
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CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES
Watts, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.821 · Cited by 763
Heat shock protein 70-associated peptides elicit specific cancer immunity.
Udono, H., & Srivastava, P. K. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.4.1391 · Cited by 621
Heat shock proteins transfer peptides during antigen processing and CTL priming
Srivastava, P., Udono, H., Blachere, N., & Li, Z. (1994) · Immunogenetics · doi:10.1007/bf00188611 · Cited by 569
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Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World
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Cited by
Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin
Basu, S., Binder, R. J., Ramalingam, T., & Srivastava, P. K. (2001) · Immunity · doi:10.1016/s1074-7613(01)00111-x · Cited by 900
Vabulas, R. M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C. J., Häcker, H., & Wagner, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103217200 · Cited by 805
CD40, an extracellular receptor for binding and uptake of Hsp70–peptide complexes
Becker, T., Hartl, F.-U., & Wieland, F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200208083 · Cited by 355
Le Naour, F., Hohenkirk, L., Grolleau, A., Misek, D. E., Lescure, P., Geiger, J. D., Hanash, S., & Beretta, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100156200 · Cited by 284
Metadata
- Authors
- Arnold-Schild, D., Hanau, D., Spehner, D., Schmid, C., Rammensee, H.-G., de la Salle, H., & Schild, H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-04-01
- Volume
- 162
- Issue
- 7
- Pages
- 3757-3760
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1574881121
- Cited by
- 398
- References
- 17
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells. https://app.cochat.ai/papers/10.4049/jimmunol.162.7.3757
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- Arnold-Schild, D., Hanau, D., Spehner, D., Schmid, C., Rammensee, H.-G., de la Salle, H., & Schild, H. (1999). Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.7.3757
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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