CoChat
Sign Up
Cited by 900

The DOI matches its Crossref record.

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

Basu, Sreyashi, Binder, Robert J., Ramalingam, Thirumalai, Srivastava, Pramod K.·2001·Immunity
DOI 10.1016/s1074-7613(01)00111-x
Open this paper in CoChat — free account

Abstract

Complexes of the heat shock protein gp96 and antigenic peptides are taken up by antigen-presenting cells and presented by MHC class I molecules. In order to explain the unusual efficiency of this process, the uptake of gp96 had been postulated to occur through a receptor, identified recently as CD91. We show here that complexes of peptides with heat shock proteins hsp90, calreticulin, and hsp70 are also taken up by macrophages and dendritic cells and re-presented by MHC class I molecules. All heat shock proteins utilize the CD91 receptor, even though some of the proteins have no homology with each other. Postuptake processing of gp96-chaperoned peptides requires proteasomes and the transporters associated with antigen processing, utilizing the classical endogenous antigen presentation pathway.

Overview

Integrity signals

Registry

Crossref · 10.1016/s1074-7613(01)00111-x

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • LRP1 is a plasma membrane receptor mediating endocytosis, phagocytosis, chemotaxis and signaling for extracellular ligands including ApoE, lipoproteins, α2-macroglobulin, proteases, extracellular matrix proteins, growth factors, complement factors, heat shock proteins and dozens of other natural ligands.

    “Low density lipoprotein (LDL) receptor related protein 1 (LRP1) is a plasma membrane receptor mediating endocytosis, phagocytosis, chemotaxis and signaling for extracellular ligands, including apolipoprotein E (ApoE), lipoproteins, α2-macroglobulin, proteases, extracellular matrix proteins, growth factors, complement factors, heat shock proteins and dozens of other natural ligands (1–5).”

    From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [2]

  • LRP1 and related LDL family receptors regulate a wide range of cellular processes, including endocytosis, phagocytosis, chemotaxis and signaling in response to dozens of ligands.

    “Outside the brain, LRP1 and related LDL family receptors regulate a wide range of cellular processes, including endocytosis, phagocytosis, chemotaxis and signaling in response to dozens of ligands (1–4).”

    From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [2]

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 34

  1. Arnold-Schild, 1999, Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells, J. Immunol., 162, 3757, 10.4049/jimmunol.162.7.3757 · DOI
  2. Basu, 1999, Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity, J. Exp. Med., 189, 797, 10.1084/jem.189.5.797 · DOI
  3. Basu, 2000, Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a maturation signal to dendritic cells and activate the NFκB pathway, Int. Immunol., 12, 1539, 10.1093/intimm/12.11.1539 · DOI
  4. Bevan, 1976, Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay, J. Exp. Med., 143, 1283, 10.1084/jem.143.5.1283 · DOI
  5. Binder, 2000, CD91, Nature Immunol., 2, 151, 10.1038/77835 · DOI
  6. Binder, 2000, Saturation, competition and specificity in interaction of heat shock proteins (hsp) gp96, hsp90, and hsp70 with CD11b+ cells, J. Immunol., 165, 2582, 10.4049/jimmunol.165.5.2582 · DOI
  7. Blachere, 1997, Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity, J. Exp. Med., 186, 1315, 10.1084/jem.186.8.1315 · DOI
  8. Breloer, 1998, Isolation of processed, H-2Kb-binding ovalbumin-derived peptides associated with the stress proteins HSP70 and gp96, Eur. J. Immunol., 28, 1016, 10.1002/(SICI)1521-4141(199803)28:03<1016::AID-IMMU1016>3.0.CO;2-G · DOI
  9. Castellino, 2000, Receptor-mediated uptake of antigen/heat shock protein complex results in major histocompatibility complex class I antigen presentation via two distinct processing pathways, J. Exp. Med., 191, 1957, 10.1084/jem.191.11.1957 · DOI
  10. Chiang, 1989, A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins, Science., 246, 382, 10.1126/science.2799391 · DOI
  11. Goretzki, 1998, Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein, Biochem. J., 336, 381, 10.1042/bj3360381 · DOI · Paper page
  12. Huang, 1996, The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product, Proc. Natl. Acad. Sci. USA, 93, 9730, 10.1073/pnas.93.18.9730 · DOI
  13. Ishii, 1999, Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96, J. Immunol., 162, 1303, 10.4049/jimmunol.162.3.1303 · DOI
  14. Lutz, 1999, An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow, J. Immunol. Methods, 223, 77, 10.1016/S0022-1759(98)00204-X · DOI
  15. Ohashi, 2000, Cutting edge, J. Immunol., 164, 558, 10.4049/jimmunol.164.2.558 · DOI
  16. Panjwani, 2000, The CD36 scavenger receptor as a receptor for gp96, Cell Stress and Chaperones, 5, 391
  17. Prodromou, 1997, Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone, Cell, 90, 65, 10.1016/S0092-8674(00)80314-1 · DOI
  18. Sandberg, 1996, TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity, Eur. J. Immunol., 26, 288, 10.1002/eji.1830260203 · DOI
  19. Singh-Jasuja, 2000, The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor, Eur. J. Immunol., 30, 2211, 10.1002/1521-4141(2000)30:8<2211::AID-IMMU2211>3.0.CO;2-0 · DOI
  20. Srivastava, P.K. (1982). Studies on cell surfaces during normal and abnormal growth: purification of a tumor-associated antigen and a tumor rejection antigen from a rat hepatoma. PhD thesis, Osmania University, Hyderabad, India.
  21. Srivastava, 1994, Heat shock proteins in immune response to cancer, Experientia, 50, 1054, 10.1007/BF01923461 · DOI
  22. Srivastava, 1997, Purification of heat shock protein-peptide complexes for use in vaccination against cancers and intracellular pathogens, Methods, 12, 165, 10.1006/meth.1997.0464 · DOI
  23. Srivastava, 1984, The serologically unique cell surface antigen of Zajdela ascitic hepatoma is also its tumor-associated transplantation antigen, Int. J. Cancer., 33, 417, 10.1002/ijc.2910330321 · DOI
  24. Srivastava, 1986, Tumor rejection antigens of chemically induced sarcomas of inbred mice, Proc. Natl. Acad. Sci. USA, 83, 3407, 10.1073/pnas.83.10.3407 · DOI
  25. Srivastava, 1994, Heat shock proteins transfer peptides during antigen processing and CTL priming, Immunogenetics, 39, 93, 10.1007/BF00188611 · DOI
  26. Srivastava, 1998, Heat shock proteins come of age, Immunity, 8, 657, 10.1016/S1074-7613(00)80570-1 · DOI
  27. Stebbins, 1997, Crystal structure of an Hsp90-geldanamycin complex, Cell, 89, 239, 10.1016/S0092-8674(00)80203-2 · DOI
  28. Suto, 1995, A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides, Science, 269, 1585, 10.1126/science.7545313 · DOI
  29. Udono, 1993, Heat shock protein 70-associated peptides elicit specific cancer immunity, J. Exp. Med., 178, 1391, 10.1084/jem.178.4.1391 · DOI
  30. Udono, 1994, Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90 and hsp70, J. Immunol., 152, 5398, 10.4049/jimmunol.152.11.5398 · DOI
  31. Udono, 1994, Cellular requirements for tumor-specific immunity elicited by heat shock proteins, Proc. Natl. Acad. Sci. USA, 91, 3077, 10.1073/pnas.91.8.3077 · DOI
  32. Ullrich, 1986, A mouse tumor-specific transplantation antigen is a heat shock-related protein, Proc. Natl. Acad. Sci. USA, 83, 3118, 10.1073/pnas.83.10.3121 · DOI
  33. Wang, 2000, Characterization of native interaction of hsp110 with hsp25 and hsc70, FEBS Lett., 465, 98, 10.1016/S0014-5793(99)01733-0 · DOI
  34. Zhu, 1996, Structural analysis of substrate binding by the molecular chaperone DnaK, Science., 272, 1606, 10.1126/science.272.5268.1606 · DOI

Cited by

Sorted by citations

Metadata

Authors
Basu, S., Binder, R. J., Ramalingam, T., & Srivastava, P. K.
Venue
Immunity
Publisher
Elsevier BV
Published
2001-03
Volume
14
Issue
3
Pages
303-313
ISSN
1074-7613
DOI
10.1016/s1074-7613(01)00111-x
Cited by
900
References
0
Language
en
Licence
Funders
National Institutes of Health (CA64394)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review