Chemokine receptors in allergic diseases

Castan, L.; Magnan, A.; Bouchaud, G.

doi:10.1111/all.13089

Cited by 80Chemokine receptors and signalingAsthma and respiratory diseasesAllergic Rhinitis and Sensitization

Chemokine receptors in allergic diseases

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Castan, L., Magnan, A., Bouchaud, G.·2017·Allergy

DOI 10.1111/all.13089

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Abstract

Under homeostatic conditions, as well as in various diseases, leukocyte migration is a crucial issue for the immune system that is mainly organized through the activation of bone marrow‐derived cells in various tissues. Immune cell trafficking is orchestrated by a family of small proteins called chemokines. Leukocytes express cell‐surface receptors that bind to chemokines and trigger transendothelial migration. Most allergic diseases, such as asthma, rhinitis, food allergies, and atopic dermatitis, are generally classified by the tissue rather than the type of inflammation, making the chemokine/chemokine receptor system a key point of the immune response. Moreover, because small antagonists can easily block such receptors, various molecules have been developed to suppress the recruitment of immune cells during allergic reactions, representing potential new drugs for allergies. We review the chemokines and chemokine receptors that are important in asthma, food allergies, and atopic dermatitis and their respectively developed antagonists.

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T cells are recruited by locally produced chemotactic mediators, and inhibiting their migration is an appealing strategy.
“T cells are recruited by locally produced chemotactic mediators, and inhibition of their migration represents an appealing strategy18,54,149,150.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [149]

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Authors: Castan, L., Magnan, A., & Bouchaud, G.
Affiliations: Centre National de la Recherche Scientifique (FR)
Biopolymères Interactions Assemblages (FR)
Corresponding author: Bouchaud, G.
ORCID: Castan, L.
Magnan, A.
Bouchaud, G.
Venue: Allergy
Publisher: Wiley
Published: 2016-12-09
Volume: 72
Issue: 5
Pages: 682-690
ISSN: 0105-4538 (ISSN-L)
1398-9995
DOI: 10.1111/all.13089
OpenAlex: W2549078849
Cited by: 80
References: 97
Citations by year: 2026: 4 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 6 · 2019: 2 · 2018: 13 · 2017: 4
FWCI: 0.64
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Allergy (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, cc-by-sa)
Funders: Fondation pour la Recherche Médicale
Ontario Ministry of Research, Innovation and Science
Seventh Framework Programme (624910)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Keywords: chemokine receptors, chemokines, allergic diseases, asthma, food allergy, atopic dermatitis, rhinitis, leukocyte migration, immune cell trafficking, chemokine antagonists, antiallergic drugs
MeSH terms: Animals, Asthma, Dermatitis, Atopic, Food Hypersensitivity, Humans, Hypersensitivity, Immune System, Chemokines, Anti-Asthmatic Agents, Receptors, Chemokine

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