Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice

Kawasaki, Shin; Takizawa, Hajime; Yoneyama, Hiroyuki; Nakayama, Takashi; Fujisawa, Ryuichi; Izumizaki, Masahiko; Imai, Toshio; Yoshie, Osamu; Homma, Ikuo; Yamamoto, Kazuhiko; Matsushima, Kouji

doi:10.4049/jimmunol.166.3.2055

Cited by 266Asthma and respiratory diseasesChemokine receptors and signalingAllergic Rhinitis and Sensitization

Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice

Kawasaki, Shin, Takizawa, Hajime, Yoneyama, Hiroyuki, Nakayama, Takashi, Fujisawa, Ryuichi, Izumizaki, Masahiko, Imai, Toshio, Yoshie, Osamu +3 more·2001·The Journal of Immunology

DOI 10.4049/jimmunol.166.3.2055

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Abstract

Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC chemokine that specifically chemoattracts CC chemokine receptor 4-positive (CCR4+) Th2 cells. To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against TARC could inhibit the induction of asthmatic reaction in mice elicited by OVA. TARC was constitutively expressed in the lung and was up-regulated in allergic inflammation. The specific Ab against TARC attenuated OVA-induced airway eosinophilia and diminished the degree of airway hyperresponsiveness with a concomitant decrease in Th2 cytokine levels. Our results for the first time indicate that TARC is a pivotal chemokine for the development of Th2-dominated experimental allergen-induced asthma with eosinophilia and AHR. This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine.

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The chemokines CCL17, CCL22 and their receptor CCR4 are each important in the development of allergic inflammation.
“The chemokines CCL17, CCL22 and their receptor CCR4, are each important in the development of allergic inflammation38–40.”
From The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation (2010) · cites this paper as [39]

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Authors: Kawasaki, S., Takizawa, H., Yoneyama, H., Nakayama, T., Fujisawa, R., Izumizaki, M., Imai, T., Yoshie, O., Homma, I., Yamamoto, K., & Matsushima, K.
Affiliations: The University of Tokyo (JP)
Kindai University (JP)
SHOWA Medical University (JP)
Corresponding author: Kawasaki, Shin
Takizawa, Hajime
Yamamoto, Kazuhiko
ORCID: Takizawa, Hajime
Nakayama, Takashi
Izumizaki, Masahiko
Imai, Toshio
Yoshie, Osamu
Yamamoto, Kazuhiko
Matsushima, Kouji
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2001-02-01
Volume: 166
Issue: 3
Pages: 2055-2062
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.166.3.2055
OpenAlex: W2161167143
Cited by: 261
References: 51
Citations by year: 2025: 3 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 9 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 12 · 2012: 11
FWCI: 14.73
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Keywords: CCL17, allergic airway inflammation, airway hyperresponsiveness, asthma, ovalbumin-induced asthma, eosinophilia, Th2 cytokines, CCR4, Th2 cells, CC chemokines
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Antibody Specificity, Asthma, Cell Movement, Disease Models, Animal, Immune Sera, Immunohistochemistry, Immunosuppressive Agents, Injections, Intraperitoneal, Lung, Lymphocyte Activation, Male, Mice, Inbred C57BL, Ovalbumin, Pulmonary Eosinophilia, RNA, Messenger, Thymus Gland, CD4-Positive T-Lymphocytes, Cytokines, Bronchial Hyperreactivity, Th2 Cells, Chemokines, CC, Mice, Chemokine CCL17

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Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice

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