Proliferation of Bone Marrow Pro-B Cells Is Dependent on Stimulation by the Pituitary/Thyroid Axis
Abstract
The frequency and absolute number of pro-B, pre-B, and B cells in the bone marrow of the hypothyroid strain of mice are significantly reduced compared with those of their normal littermates. To investigate why this is the case, various B cell developmental processes were examined in the thyroid hormone-deficient mice. These studies revealed that the frequency of pro-B cells in the S-G2/M phase of the cell cycle was significantly reduced in hypothyroid mice. That thyroid hormone deficiency was responsible for this proliferation defect was established by demonstrating that treatment of hypothyroid mice with thyroxine resulted in a specific increase in the frequency and total number of cycling pro-B cells. The latter effect was paralleled by increases in the frequency and number of bone marrow B lineage cells. Additional in vitro experiments revealed that at least some thyroid hormone effects were directly mediated on the bone marrow. Taken together, these data demonstrate that thyroid hormones are required for normal B cell production in the bone marrow through regulation of pro-B cell proliferation and establish a role for the pituitary/thyroid axis in B cell development.
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Thyroid hormones are required for normal B-cell production in the bone marrow.
“Thyroid hormones are required for normal B-cell production in the bone marrow [130].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [130]
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Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“duction in the bone marrow [130].”
Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts
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- Authors
- Foster, M. P., Montecino-Rodriguez, E., & Dorshkind, K.
- Affiliations
- University of California, Los Angeles (US)
- Department of Pathology and Laboratory Medicine and Jonsson Comprehensive Cancer Center, School of Medicine, University of California , Los Angeles, CA 90095
- ORCID
- Dorshkind, Kenneth
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-12-01
- Volume
- 163
- Issue
- 11
- Pages
- 5883-5890
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2155455544
- Cited by
- 75
- References
- 60
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 1 · 2017: 2 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA-16 042, P30CA016042)
- National Institute of Allergy and Infectious Diseases (AI21256)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- pro-B cells, B cell development, thyroid hormones, hypothyroidism, thyroxine, pituitary-thyroid axis, bone marrow, cell cycle, B-cell lineage, B cell proliferation
- MeSH terms
- Animals, B-Lymphocytes, Bone Marrow, Cell Division, Cells, Cultured, Fluorouracil, Hematopoietic Stem Cells, Hypothyroidism, Immunoglobulin M, Mice, Mutant Strains, Pituitary Gland, Receptors, Antigen, B-Cell, Thyroid Gland, Thyroid Hormones, Triiodothyronine, Apoptosis, Leukocyte Common Antigens, Cell Lineage, Mice
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