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The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns
Open accessAbstract
The human liver contains significant numbers of T cells, NK cells, and lymphocytes that coexpress T and NK cell receptors. To evaluate their functional activities, we have compared the cytotoxic activities and cytokines produced by normal adult hepatic CD3+CD56− (T) cells, CD3−CD56+ (NK) cells, and CD3+CD56+ (natural T (NT)) cells. In cytotoxicity assays using immunomagnetic bead-purified NK cell, T cell, and NT cell subpopulations as effectors, fresh hepatic NK cells lysed K562 targets, while NT cells could be induced to do so by culturing with IL-2. Both NT and T cells were capable of redirected cytolysis of P815 cells using Abs to CD3. Flow cytometric analysis of cytokine production by fresh hepatic lymphocyte subsets activated by CD3 cross-linking or PMA and ionomycin stimulation indicated that NT cells and T cells could produce IFN-γ, TNF-α, IL-2, and/or IL-4, but little or no IL-5, while NK cells produced IFN-γ and/or TNF-α only. The majority of NT cells produced inflammatory (Th1) cytokines only; however, ∼6% of all hepatic T cells, which included 5% of Vα24 TCR-bearing NT cells and 2% of γδTCR+ cells, simultaneously produced IFN-γ and IL-4. The existence of such large numbers of cytotoxic lymphocytes with multiple effector functions suggests that the liver is an important site of innate immune responses, early regulation of adaptive immunity, and possibly peripheral deletion of autologous cells.
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“NKs represent the largest population of lymphocytes in the liver(72, 73).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [73]
Citations
Cites
Functional diversity of helper T lymphocytes
Abbas, A. K., MURPHY, K. M. M., & Sher, A. (1996) · Nature · doi:10.1038/383787a0 · Cited by 4,432
CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400
Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M. (1997) · Science · doi:10.1126/science.278.5343.1623 · Cited by 1,237
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
Groh, V., Steinle, A., Bauer, S., & Spies, T. A. (1998) · Science · doi:10.1126/science.279.5357.1737 · Cited by 1,142
Lantz, O. J., & Bendelac, A. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,036
Recognition of a lipid antigen by CD1-restricted αβ+ T cells
Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994) · Nature · doi:10.1038/372691a0 · Cited by 977
CD1 Recognition by Mouse NK1 + T Lymphocytes
Bendelac, A. S., Lantz, O. J., Quimby, M. E., Yewdell, J. W., Bennink, J. R., & Brutkiewicz, R. R. (1995) · Science · doi:10.1126/science.7538697 · Cited by 912
CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens
Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T. T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., et al. (1995) · Science · doi:10.1126/science.7542404 · Cited by 727
Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes
Wilson, S. B., Kent, S. C., Patton, K. T., Orban, T., Jackson, R. A., Exley, M. A., Porcelli, S. A., Schatz, D., Atkinson, M. A., Balk, S. P., et al. (1998) · Nature · doi:10.1038/34419 · Cited by 646
Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P., & Kronenberg, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.8.1521 · Cited by 642
Flagged first, then by citations
Research works printed but not linked: 52
- 1992, Hepatology, 816
- 1998, J. Hepatol., 84
- 1994, J. Exp. Med., 699
- 1997, Hepatology, 301
- 1995, Science, 1845
- 1996, J. Exp. Med., 2391
- 1997, J. Immunol., 2240
- 1994, J. Exp. Med., 1097
- 1995, Science, 863
- 1997, Science, 1626
- 1991, Cell Immunol., 486
- 1994, Eur. J. Immunol., 2294
- 1995, Science, 403
- 1995, Int. Immunol., 697
- 1997, J. Exp. Med., 109
- 1998, J. Exp. Med., 1521
- 1998, J. Exp. Med., 1529
- 1997, J. Immunol., 5862
- 1999, Hum. Immunol., 20
- 1990, J. Immunol., 1039
- 1996, J. Immunol., 3366
- 1997, Science, 1623
- 1995, J. Immunol., 4333
- 1996, Int. Immunol., 1759
- 1997, Eur. J. Immunol., 183
- 1997, Int. Immunol., 73
- 1998, Eur. J. Immunol., 1507
- 1998, J. Immunol., 1239
- 1998, J. Immunol., 3527
- 1991, Hepatology, 495
- 1994, Transplantation, 496
- 1996, J. Immunol., 2436
- 1996, J. Immunol., 3886
- 1995, J. Immunol. Methods, 117
- 1995, Blood, 1408
- 1995, J. Exp. Med., 1357
- 1992, Hepatology, 1112
- 1997, Am. J. Physiol., G322
- 1996, Nature, 787
- 1997, J. Immunol., 3723
- 1989, Nature, 447
- 1990, Eur. J. Immunol., 703
- 1994, Nature, 691
- 1995, Science, 227
- 1994, J. Immunol., 3074
- 1995, J. Exp. Med., 1163
- 1998, Nature, 177
- 1994, Immunity, 741
- 1994, Int. Immunol., 533
- 1991, J. Immunol., 2907
- 1998, Science, 1737
- 1990, Int. J. Cancer, 373
Cited by
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Items 201–300 of 349
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Naidenko, O. V., Koezuka, Y., & Kronenberg, M. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00363-4 · Cited by 21
Functional evaluation of ex vivo expanded cord blood lymphocytes
Azuma, H., Yamada, Y., Shibuya-Fujiwara, N., Yamaguchi, M., Murahashi, H., Fujihara, M., Sato, N., Fukazawa, K., Ikebuchi, K., & Ikeda, H. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00776-2 · Cited by 21
Cross-talk between hepatic stellate cells and T lymphocytes in liver fibrosis
Li, H., Ding, P., Peng, B., & Ming, Y. (2021) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2021.04.007 · Cited by 21
Chen, G., Hu, X., Huang, Y., Xiang, X., Pan, S., Chen, R., & Xu, X. (2023) · MedComm · doi:10.1002/mco2.444 · Cited by 22
Effects of organochlorine pesticides on interleukin secretion from lymphocytes
Beach, T. M., & Whalen, M. M. (2006) · Human & Experimental Toxicology · doi:10.1177/0960327106070072 · Cited by 20
Larner, D. P., Morgan, S., Gathercole, L., Doig, C. L., Guest, P., Weston, C. J., Hazeldine, J., Tomlinson, J., Stewart, P. M., & Lavery, G. G. (2016) · Endocrinology · doi:10.1210/en.2016-1357 · Cited by 21
α-Fetoprotein and other tumour-associated antigens for immunotherapy of hepatocellular cancer
Evdokimova, V. N., & Butterfield, L. H. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.3.325 · Cited by 20
Hepatic expression of IL-15 mRNA is associated with liver graft acceptance
Cookson, S., Doherty, D. G., Todryk, S. M., Gibbs, P., Portmann, B. C., O’Grady, J., Rela, M., Heaton, N. D., & Norris, S. (2003) · Transplant Immunology · doi:10.1016/s0966-3274(02)00143-0 · Cited by 20
Self-citationConroy, M. J., Nicholas, R. M., Grealy, R., Taylor, M., Otegbayo, J. A., O’Dea, S., Mulcahy, F. M., Ryan, T., Norris, S., & Doherty, D. G. (2014) · Journal of Viral Hepatitis · doi:10.1111/jvh.12299 · Cited by 19
Self-citationSynergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells
Tu, Z., Hamalainen-Laanaya, H. K., Crispe, I. N., & Orloff, M. S. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.07.006 · Cited by 19
Reduced Degranulation of NK Cells in Patients with Frequently Recurring Herpes
Владимирович, М. В., Zuikova, I. N., Евгеньевна, М. Н., Евгеньевич, Ш. А., Pinegin, B. V., & Pashenkov, M. V. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.05084-11 · Cited by 19
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Cohavy, O., Shih, D. Q., Doherty, T. M., Ware, C. F., & Targan, S. R. (2011) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi.1.2011.1.9 · Cited by 19
Conroy, M., Galvin, K. C., Doyle, S., Kavanagh, M., Mongan, A., Cannon, A., Moore, G., Reynolds, J., & Lysaght, J. (2016) · Inflammation · doi:10.1007/s10753-016-0407-2 · Cited by 18
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Easom, N. J. W., Marks, M., Jobe, D., Gillmore, R., Meyer, T., Maini, M. K., & Njie, R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00971 · Cited by 19
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Rennert, C., Tauber, C., Fehrenbach, P., Heim, K., Bettinger, D., Sogukpinar, O., Schuch, A., Zecher, B. F., Bengsch, B., Lang, S. A., et al. (2021) · Cells · doi:10.3390/cells10061369 · Cited by 19
CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver
Kenna, T., O’Brien, M., Hogan, A. E., Exley, M. A., Porcelli, S. A., Hegarty, J. E., O’Farrelly, C., & Doherty, D. G. (2006) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-006-0215-x · Cited by 19
Self-citationKelly, A. (2004) · Cytokine · doi:10.1016/j.cyto.2003.11.012 · Cited by 19
Comparison ofp53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma
Gökgöz, N., Wunder, J. S., Mousses, S., Eskandarian, S., Bell, R. S., & Andrulis, I. L. (2001) · Cancer · doi:10.1002/1097-0142(20011015)92:8 · Cited by 125
Self-citationLiver immunity and tumour surveillance
Canning, C., O’Brien, M., Hegarty, J. E., & O’Farrelly, C. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.07.002 · Cited by 20
Self-citationOKUMURA, A., ISHIKAWA, T., Maeno, T., SATO, K., Ayada, M., HOTTA, N., Yamauchi, T., FUKUZAWA, Y., & Kakumu, S. (2005) · Hepatology Research · doi:10.1016/j.hepres.2005.02.008 · Cited by 19
Donadon, M., Lleò, A., Tommaso, L. D., Soldani, C., Franceschini, B., Roncalli, M. G., & Torzilli, G. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00181 · Cited by 20
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Jameson, G., & Robinson, M. W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.649311 · Cited by 19
O’Keeffe, J., Gately, C. M., O’Donoghue, Y., Zulquernain, S. A., Stevens, F. M., & Moran, A. P. (2008) · Helicobacter · doi:10.1111/j.1523-5378.2008.00641.x · Cited by 17
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Morishita, A., Oura, K., Tadokoro, T., Fujita, K., Tani, J., & Masaki, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073554 · Cited by 17
Vacani-Martins, N., Meuser-Batista, M., dos Santos, C. D. L. P., Hasslocher‐Moreno, A. M., & Henriques‐Pons, A. (2021) · Pathogens · doi:10.3390/pathogens10091074 · Cited by 17
Hus, I., Starosławska, E., Bojarska-Junak, A. A., Dobrzyńska‐Rutkowska, A., Surdacka, A., Wdowiak, P., Wasiak, M., Kusz, M. L., Twardosz, A., Dmoszyńska, A., et al. (2011) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.2011.0025 · Cited by 17
Li, N., Yung, G. P., Pradier, A., Toso, C., Giostra, E., Morard, I., Spahr, L., & Seebach, J. D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00061 · Cited by 18
Matsui, T., Nagai, H., Sumino, Y., & Miki, K. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0618-1 · Cited by 17
Prell, C., Konstantopoulos, N., Heinzelmann, B., Frankenberger, B., Reinhardt, D., Schendel, D. J., & Krauss‐Etschmann, S. (2003) · Immunobiology · doi:10.1078/0171-2985-00284 · Cited by 17
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Michalak, T. I. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7903-3_5 · Cited by 16
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Adar, T., & Ilan, Y. (2008) · Journal of Immunotoxicology · doi:10.1080/15476910802129620 · Cited by 15
Saikh, K. U., Kissner, T. L., & Ulrich, R. G. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01446.x · Cited by 15
Immunologic States of Autoimmune Diseases
Abo, T., Kawamura, T., & Watanabe, H. (2005) · Immunologic Research · doi:10.1385/ir:33:1:023 · Cited by 15
Sekiguchi, T. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i13.2089 · Cited by 14
Control or persistence of hepatitis B virus: The critical role of initial host–virus interactions
Webster, G. J. M., & Bertoletti, A. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01060.x · Cited by 14
Dysfunction of circulating CD3+CD56+ NKT-like cells in type 2 diabetes mellitus
Tang, L., Wang, H., Cao, K., Xu, C., Ma, A., Zheng, M., Xu, Y., & Zhang, M. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.83317 · Cited by 13
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Lapierre, P., & Álvarez, F. (2007) · médecine/sciences · doi:10.1051/medsci/20072311985 · Cited by 13
Dean, J., McCarthy, D., Lawler, M., Doherty, D. G., O’Farrelly, C., & Golden‐Mason, L. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.08.017 · Cited by 13
Self-citationMadrigal-Estebas, L., Doherty, D. G., OʼDonoghue, D. P., Feighery, C., & O’Farrelly, C. (2002) · Mediators of Inflammation · doi:10.1080/09629350210000015728 · Cited by 13
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Saeki, Y., Ishiyama, K., Ishida, N., Tanaka, Y., & Ohdan, H. (2019) · Scientific Reports · doi:10.1038/s41598-018-37395-9 · Cited by 11
Doyle, E., Aloman, C., El‐Shamy, A., Eng, F. J., Rahman, A. H., Klepper, A. L., Haydel, B., Florman, S. S., Fiel, M. I., Schiano, T. D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80819-8 · Cited by 12
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Lǐ, J. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i16.2357 · Cited by 12
Miyakawa, R., Ichida, T., Yamagiwa, S., Miyaji, C., Watanabe, H., Sato, Y., Yokoyama, H., Tsukada, C., Ishimoto, Y., Sugahara, S., et al. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.03245.x · Cited by 12
Li, X., Dai, D., Song, X., Liu, J., Zhu, L., Zhu, X., Ma, W., & Xu, W. (2017) · Oncology Letters · doi:10.3892/ol.2017.5808 · Cited by 10
Koike, Y., SEKI, S., OHKAWA, T., Kaneko, T., Kogawa, K., Fujitsuka, S., Hiraide, H., & Sekine, I. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01958.x · Cited by 11
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Buxbaum, J. L., Qian, P., Khuu, C., Shneider, B. L., Daikh, D., Gershwin, M. E., Allen, P. M., & Peters, M. G. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.020 · Cited by 11
CD56+ T cells inhibit HIV-1 infection of macrophages
Hou, W., Ye, L., & Ho, W. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0312146 · Cited by 11
Au, K. P., Chok, K., Chan, A. C. Y., Dai, W. C., Cheung, T. T., & Lo, C. M. (2018) · World Journal of Surgery · doi:10.1007/s00268-018-4483-3 · Cited by 10
Cheng, Z., Ferris, C. P., Crowe, M. A., Ingvartsen, K. L., Grelet, C., Vanlierde, A., Foldager, L., Becker, F. O., & Wathes, D. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129906 · Cited by 13
Zhong, Y., Xu, M., Hu, J., Huang, X., Lin, N., & Deng, M. (2021) · Aging · doi:10.18632/aging.202425 · Cited by 11
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Nassiri, I., Masoudi‐Nejad, A., Jalili, M., & Moeini, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039643 · Cited by 10
Human NKT cells in health and disease
Tarazona, R., DelaRosa, O., Peralbo, E., Peña, J., Solana, R., & Sofía, R. (2003) · Cited by 10
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Thulesen, S., Nissen, M. H., Ødum, N., & Röpke, C. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/107999001753289514 · Cited by 10
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Saikh, K. U., Dyas, B. K., Kissner, T. L., & Ulrich, R. G. (2003) · Clinical and Vaccine Immunology · doi:10.1128/cdli.10.6.1065-1073.2003 · Cited by 10
Cao, K., Wang, X., Wang, H. ‐., Xu, C., Ma, A., Zhang, Y., Zheng, M., Xu, Y., & Tang, L. (2024) · The FASEB Journal · doi:10.1096/fj.202301743r · Cited by 9
Wu, N., Zhang, X.-Y., Huang, B., Zhang, N., Zhang, X., Guo, X., Chen, X., Zhang, Y., Wu, H., Li, S., et al. (2015) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2015.08.006 · Cited by 9
Epidemiology of hepatitis B, C, D and G viruses and cytokine levels among intravenous drug users
Li, J., Wang, J., Kunlun, T., Wang, Y., Zhang, L., & Hanju, H. (2006) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/bf02895821 · Cited by 9
Ex vivo purification and characterization of human invariant natural killer T cells
Sharma, A., Chew, L. H., Ladd, M., Jen, R., & Lavoie, P. M. (2011) · Journal of Immunological Methods · doi:10.1016/j.jim.2011.08.002 · Cited by 9
Zhang, G., Nichols, R. D., Taniguchi, M., Nakayama, T., & Parmely, M. J. (2003) · Infection and Immunity · doi:10.1128/iai.71.5.2468-2477.2003 · Cited by 9
Guo, C., Shen, X., Fu, B., Liu, Y., Chen, Y., Ni, F., Ye, Y., Sun, R., Li, J., Tian, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep25567 · Cited by 8
Shawa, I. T., Felmlee, D. J., Hegazy, D., Sheridan, D. A., & Cramp, M. (2017) · Journal of Viral Hepatitis · doi:10.1111/jvh.12720 · Cited by 8
Sakaguchi, E. (2002) · Hepatology Research · doi:10.1016/s1386-6346(02)00090-6 · Cited by 8
Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model
Fahrner, R., Gröger, M., Settmacher, U., & Mosig, A. S. (2023) · BMC Research Notes · doi:10.1186/s13104-023-06575-w · Cited by 7
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Sho, T., Hachisuga, T., Koi, C., Kurita, T., Kagami, S., Kawagoe, T., Matsuura, Y., Yoshimura, K., & Hisaoka, M. (2017) · Climacteric · doi:10.1080/13697137.2017.1377173 · Cited by 7
Sung, P. S., Choi, H. B., Kim, S., Hong, S. W., Park, C.-H., Song, M. J., Lee, S. W., You, C. R., Choi, S. W., Han, N. I., et al. (2011) · Journal of Korean Medical Science · doi:10.3346/jkms.2011.26.11.1483 · Cited by 7
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Innate Immune Mechanisms in the Liver
O’Farrelly, C., & Doherty, D. G. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-518-3_4 · Cited by 6
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Li, X., Gu, Y., Xiaobo, G., Gu, L., Zhou, L., Wu, X., Wang, X., Stamataki, Z., & Huang, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-06192-1 · Cited by 6
Dai, H., Zhou, Y., Tong, C., Guo, Y., Shi, F., Wang, Y., & Shen, P. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2018.07.003 · Cited by 6
MHC class II‐expressing thymocytes suppress invariant NKT cell development
Li, W., Sofi, M. H., Wei, D. G., Du, W., Gervay‐Hague, J., Renukaradhya, G. J., Brutkiewicz, R. R., & Chang, C. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.78 · Cited by 6
den Dulk, M., & Bishop, G. A. (2003) · PubMed · Cited by 6
Davey, M. P., Rosen, H. R., Woody, C. N., Haley, D. P., Kurkinen, J., & Lewinsohn, D. M. (2001) · Liver Transplantation · doi:10.1053/jlts.2001.26058 · Cited by 6
Alterations in NK Cell Phenotype in Relation to Liver Steatosis in Children with Chronic Hepatitis C
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Metadata
- Authors
- Doherty, D. G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J. E., & O’Farrelly, C.
- Affiliations
- University College Dublin (IE)
- St. Vincent's University Hospital (IE)
- Corresponding author
- Norris, Suzanne
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 163
- Issue
- 4
- Pages
- 2314-2321
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2139250003
- Cited by
- 350
- References
- 53
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 15 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 11 · 2012: 7
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- hepatic lymphocytes, natural killer cells, T cells, CD3+CD56+ cells, cytotoxicity, cytokine production, Th1 cytokines, Th2 cytokines, interleukin-2, interferon-gamma, TNF-α, IL-4, γδ T cells, innate immunity, liver
- MeSH terms
- Adult, Cell Separation, Cells, Cultured, Cytotoxicity, Immunologic, Humans, Killer Cells, Natural, Liver, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic, Killer Cells, Lymphokine-Activated, Lymphocyte Subsets, Cytokines, CD3 Complex, Th1 Cells, Th2 Cells, CD56 Antigen
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