Cited by 350Immune Cell Function and InteractionT-cell and B-cell ImmunologyReproductive System and Pregnancy

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns

Open access

Doherty, Derek G, Norris, Suzanne, Madrigal-Estebas, Laura, McEntee, Gerry, Traynor, Oscar, Hegarty, John E, O’Farrelly, Cliona·1999·The Journal of Immunology

DOI 10.4049/jimmunol.163.4.2314

Open this paper in CoChat — free account Open PDF

Abstract

The human liver contains significant numbers of T cells, NK cells, and lymphocytes that coexpress T and NK cell receptors. To evaluate their functional activities, we have compared the cytotoxic activities and cytokines produced by normal adult hepatic CD3+CD56− (T) cells, CD3−CD56+ (NK) cells, and CD3+CD56+ (natural T (NT)) cells. In cytotoxicity assays using immunomagnetic bead-purified NK cell, T cell, and NT cell subpopulations as effectors, fresh hepatic NK cells lysed K562 targets, while NT cells could be induced to do so by culturing with IL-2. Both NT and T cells were capable of redirected cytolysis of P815 cells using Abs to CD3. Flow cytometric analysis of cytokine production by fresh hepatic lymphocyte subsets activated by CD3 cross-linking or PMA and ionomycin stimulation indicated that NT cells and T cells could produce IFN-γ, TNF-α, IL-2, and/or IL-4, but little or no IL-5, while NK cells produced IFN-γ and/or TNF-α only. The majority of NT cells produced inflammatory (Th1) cytokines only; however, ∼6% of all hepatic T cells, which included 5% of Vα24 TCR-bearing NT cells and 2% of γδTCR+ cells, simultaneously produced IFN-γ and IL-4. The existence of such large numbers of cytotoxic lymphocytes with multiple effector functions suggests that the liver is an important site of innate immune responses, early regulation of adaptive immunity, and possibly peripheral deletion of autologous cells.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.163.4.2314

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Functional diversity of helper T lymphocytes
Abbas, A. K., MURPHY, K. M. M., & Sher, A. (1996) · Nature · doi:10.1038/383787a0 · Cited by 4,432
CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400
Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M. (1997) · Science · doi:10.1126/science.278.5343.1623 · Cited by 1,237
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
Groh, V., Steinle, A., Bauer, S., & Spies, T. A. (1998) · Science · doi:10.1126/science.279.5357.1737 · Cited by 1,142
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.
Lantz, O. J., & Bendelac, A. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,036
Recognition of a lipid antigen by CD1-restricted αβ+ T cells
Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994) · Nature · doi:10.1038/372691a0 · Cited by 977
CD1 Recognition by Mouse NK1 + T Lymphocytes
Bendelac, A. S., Lantz, O. J., Quimby, M. E., Yewdell, J. W., Bennink, J. R., & Brutkiewicz, R. R. (1995) · Science · doi:10.1126/science.7538697 · Cited by 912
CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens
Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T. T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., et al. (1995) · Science · doi:10.1126/science.7542404 · Cited by 727
Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes
Wilson, S. B., Kent, S. C., Patton, K. T., Orban, T., Jackson, R. A., Exley, M. A., Porcelli, S. A., Schatz, D., Atkinson, M. A., Balk, S. P., et al. (1998) · Nature · doi:10.1038/34419 · Cited by 646
CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution
Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P., & Kronenberg, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.8.1521 · Cited by 642

Flagged first, then by citations

Show all 53 references

Research works printed but not linked: 52

1992, Hepatology, 816
1998, J. Hepatol., 84
1994, J. Exp. Med., 699
1997, Hepatology, 301
1995, Science, 1845
1996, J. Exp. Med., 2391
1997, J. Immunol., 2240
1994, J. Exp. Med., 1097
1995, Science, 863
1997, Science, 1626
1991, Cell Immunol., 486
1994, Eur. J. Immunol., 2294
1995, Science, 403
1995, Int. Immunol., 697
1997, J. Exp. Med., 109
1998, J. Exp. Med., 1521
1998, J. Exp. Med., 1529
1997, J. Immunol., 5862
1999, Hum. Immunol., 20
1990, J. Immunol., 1039
1996, J. Immunol., 3366
1997, Science, 1623
1995, J. Immunol., 4333
1996, Int. Immunol., 1759
1997, Eur. J. Immunol., 183
1997, Int. Immunol., 73
1998, Eur. J. Immunol., 1507
1998, J. Immunol., 1239
1998, J. Immunol., 3527
1991, Hepatology, 495
1994, Transplantation, 496
1996, J. Immunol., 2436
1996, J. Immunol., 3886
1995, J. Immunol. Methods, 117
1995, Blood, 1408
1995, J. Exp. Med., 1357
1992, Hepatology, 1112
1997, Am. J. Physiol., G322
1996, Nature, 787
1997, J. Immunol., 3723
1989, Nature, 447
1990, Eur. J. Immunol., 703
1994, Nature, 691
1995, Science, 227
1994, J. Immunol., 3074
1995, J. Exp. Med., 1163
1998, Nature, 177
1994, Immunity, 741
1994, Int. Immunol., 533
1991, J. Immunol., 2907
1998, Science, 1737
1990, Int. J. Cancer, 373

Sorted by citations

Items 101–200 of 349

Vdelta1 T lymphocytes expressing a Th1 phenotype are the major gammadelta T cell subset infiltrating the liver of HCV-infected persons.
Agrati, C., D’Offizi, G., Narciso, P., Abrignani, S., Ippolito, G., Colizzi, V., & Poccia, F. (2001) · PubMed Central · Cited by 60
Cytokines and chemokines in the immune response to hepatitis C infection
Heydtmann, M., Shields, P. L., McCaughan, G. W., & Adams, D. (2001) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200106000-00006 · Cited by 60
Intrahepatic natural killer T cell populations are increased in human hepatic steatosis
Adler, M. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i13.1725 · Cited by 57
Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterisation
Curry, M. P., Norris, S., Golden‐Mason, L., Doherty, D. G., Deignan, T., Collins, C., Traynor, O., McEntee, G., Hegarty, J. E., & O’Farrelly, C. (2000) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00204-0 · Cited by 57
Self-citation
Brief Butyltin Exposure Induces Irreversible Inhibition of the Cytotoxic Function on Human Natural Killer Cells, In Vitro
Whalen, M. M., Green, S. A., & Loganathan, B. G. (2002) · Environmental Research · doi:10.1006/enrs.2001.4318 · Cited by 57
Bronchoalveolar Immunologic Profile of Acute Human Lung Transplant Allograft Rejection
Gregson, A. L., Hoji, A., Saggar, R., Ross, D. J., Kubak, B., Jamieson, B. D., Weigt, S. S., Lynch, J. P., Ardehali, A. A., Belperio, J. A., et al. (2008) · Transplantation · doi:10.1097/tp.0b013e318169bd85 · Cited by 56
Vδ1T Lymphocytes Expressing a Th1 Phenotype Are the Major γδ T Cell Subset Infiltrating the Liver of HCV-infected Persons
Agrati, C., D’Offizi, G., Narciso, P., Abrignani, S., Ippolito, G., Colizzi, V., & Poccia, F. (2001) · Molecular Medicine · doi:10.1007/bf03401834 · Cited by 56
T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to α-galactosylceramide are impaired
O’Keeffe, J., Gately, C. M., Counihan, T. J., Hennessy, M. J., Leahy, T., Moran, A. P., & Hogan, E. L. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.07.007 · Cited by 53
The immunosuppressive tumor microenvironment in hepatocellular carcinoma
Pang, Y., Zhang, H., Peng, J., Pang, X., Yu, S., Xing, Q. R., Yu, X., Gong, L., Yin, Y., Zhang, Y. X., et al. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0603-5 · Cited by 53
EXPRESSION OF INTERLEUKIN 7 (IL-7) mRNA AND PROTEIN IN THE NORMAL ADULT HUMAN LIVER: IMPLICATIONS FOR EXTRATHYMIC T CELL DEVELOPMENT
Golden‐Mason, L., Kelly, A. M., Traynor, O., McEntee, G., Kelly, J., Hegarty, J. E., & O’Farrelly, C. (2001) · Cytokine · doi:10.1006/cyto.2001.0852 · Cited by 53
Self-citation
The liver as a central "hub" of the immune system: pathophysiological implications
Ronca, V., Gerussi, A., Collins, P., Parente, A., Oo, Y. H., & Invernizzi, P. (2025) · Physiological Reviews · doi:10.1152/physrev.00004.2023 · Cited by 59
Decrease in intrahepatic CD56+ lymphocytes in gastric and colorectal cancer patients with liver metastases
Gulubova, M. V., Manolova, I., Kyurkchiev, D. S., Julianov, A. E., & Altŭnkova, I. (2009) · Apmis · doi:10.1111/j.1600-0463.2009.02547.x · Cited by 51
Tissue-specific NK cell populations and their origin
Lysakova-Devine, T., & O’Farrelly, C. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1ru0514-241r · Cited by 54
Self-citation
Treatment of chronic hepatitis B virus infection via oral immune regulation toward hepatitis B virus proteins
Safadi, R., Israeli, E., Papo, O., Shibolet, O., Melhem, A., Bloch, A., Rowe, M., Alper, R., Klein, A., Hemed, N., et al. (2003) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(03)00706-8 · Cited by 50
Immune Cell Trafficking to the Liver
Chaudhry, S., Emond, J. C., & Griesemer, A. (2019) · Transplantation · doi:10.1097/tp.0000000000002690 · Cited by 51
CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes†
Ye, L., Wang, X., Wang, S., Wang, Y., Song, L., Hou, W., Zhou, L., Li, H., & Ho, W. (2008) · Hepatology · doi:10.1002/hep.22715 · Cited by 49
Therapeutic vaccination in chronic hepatitis B virus carriers
Pol, S., & Michel, M. (2006) · Expert Review of Vaccines · doi:10.1586/14760584.5.5.707 · Cited by 49
Progresses in biomarkers for cancer immunotherapy
Lin, X., Zong, C., Zhang, Z., Fang, W., & Xu, P. (2023) · MedComm · doi:10.1002/mco2.387 · Cited by 50
Candida albicans Stimulates IL-23 Release by Human Dendritic Cells and Downstream IL-17 Secretion by Vδ1 T Cells
Maher, C. O., Dunne, K., Comerford, R., O’Dea, S., Loy, A., Woo, J., Rogers, T. R., Mulcahy, F. M., Dunne, P. J., & Doherty, D. G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403066 · Cited by 50
Self-citation
(E)-4-Hydroxy-3-methyl-but-2 enyl pyrophosphate-stimulated Vγ9Vδ2 T cells possess T helper type 1-promoting adjuvant activity for human monocyte-derived dendritic cells
Dunne, M. R., Madrigal-Estebas, L., Tobin, L. M., & Doherty, D. G. (2010) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-010-0839-8 · Cited by 48
Self-citation
CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver
Iiai, T., Watanabe, H., Suda, T., OKAMOTO, H., Abo, T., & Hatakeyama, K. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01886.x · Cited by 48
Fetal liver development and implications for liver disease pathogenesis
Lotto, J., Stephan, T. L., & Hoodless, P. A. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00775-2 · Cited by 47
NK Cells and Other Cytotoxic Innate Lymphocytes in Colorectal Cancer Progression and Metastasis
Fionda, C., Scarno, G., Stabile, H., Molfetta, R., Censo, C. D., Gismondi, A., Paolini, R., Sozzani, S., Santoni, A., & Sciumè, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147859 · Cited by 47
Sustained response to interferon‐α plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells
Yamagiwa, S., Matsuda, Y., Ichida, T., Honda, Y., Takamura, M., Sugahara, S., Ishikawa, T., Ohkoshi, S., Sato, Y., & Aoyagi, Y. (2008) · Hepatology Research · doi:10.1111/j.1872-034x.2008.00317.x · Cited by 47
Increased numbers and functional activity of CD 56+ T cells in healthy cytomegalovirus positive subjects
Almehmadi, M. M., Flanagan, B., Khan, N., Alomar, S. Y., & Christmas, S. E. (2014) · Immunology · doi:10.1111/imm.12250 · Cited by 50
TLR7/8 Agonist-Loaded Nanoparticles Augment NK Cell-Mediated Antibody-Based Cancer Immunotherapy
Kim, H., Khanna, V., Kucaba, T. A., Zhang, W., Sehgal, D. N., Ferguson, D. M., Griffith, T. S., & Panyam, J. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00271 · Cited by 49
Butyltin Exposure Causes a Rapid Decrease in Cyclic AMP Levels in Human Lymphocytes
Whalen, M. M., & Loganathan, B. G. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.9121 · Cited by 46
Natural Killer–Dendritic Cell Interactions in Liver Cancer: Implications for Immunotherapy
Cazzetta, V., Franzese, S., Carenza, C., Bella, S. D., Mikulak, J., & Mavilio, D. (2021) · Cancers · doi:10.3390/cancers13092184 · Cited by 47
T Cells Infiltrating Diseased Liver Express Ligands for the NKG2D Stress Surveillance System
Huang, W., Easom, N. J. W., Tang, X.-Z. E., Gill, U. S., Singh, H., Robertson, F. P., Chang, C., Trowsdale, J., Davidson, B. R., Rosenberg, W. M., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601313 · Cited by 44
Stress kinases in the development of liver steatosis and hepatocellular carcinoma
Cicuéndez, B., Ruiz-Garrido, I., Mora, A., & Sabio, G. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101190 · Cited by 45
Role of Immune Cells in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma
Cho, H. J., & Cheong, J. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158011 · Cited by 51
Development of Immunocompetence: Role of Micronutrients and Microorganisms
Cunningham–Rundles, S., Ahrn�, S., Abuav-Nussbaum, R., & Dnistrian, A. M. (2002) · Nutrition Reviews · doi:10.1301/00296640260130777 · Cited by 44
Therapeutic vaccination against chronic hepatitis B virus infection
Michel, M., & Bourgine, M. (2005) · Journal of Clinical Virology · doi:10.1016/s1386-6532(05)80019-8 · Cited by 43
Association of NKG2A with treatment for chronic hepatitis C virus infection
Harrison, R. J., Ettorre, A., Little, A., & Khakoo, S. I. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04169.x · Cited by 42
Virus stimulation of human mast cells results in the recruitment of CD56 + T cells by a mechanism dependent on CCR5 ligands
McAlpine, S. M., Issekutz, T. B., & Marshall, J. S. (2011) · The FASEB Journal · doi:10.1096/fj.11-188979 · Cited by 42
CD56+dim and CD56+bright cell activation and apoptosis in hepatitis C virus infection
Lin, A., Gonzalez, S. A., Cunningham-Rundles, S., Dorante, G., MARSHALL, S., TIGNOR, A., HA, C., Jacobson, I. M., & Talal, A. H. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02523.x · Cited by 42
The role of natural killer T cells in B cell malignancies
Ghalamfarsa, G., Hadinia, A., Yousefi, M., & Jadidi‐Niaragh, F. (2013) · Tumor Biology · doi:10.1007/s13277-013-0743-x · Cited by 41
Immunomodulation of human natural killer cell cytotoxic function by organochlorine pesticides
Reed, A., Dzon, L., Loganathan, B. G., & Whalen, M. M. (2004) · Human & Experimental Toxicology · doi:10.1191/0960327104ht477oa · Cited by 41
HBV infection decreases risk of liver metastasis in patients with colorectal cancer: A cohort study
Qiu, H. B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i6.804 · Cited by 40
Functional and Vβ repertoire characterization of human CD8+ T‐cell subsets with natural killer cell markers, CD56+ CD57− T cells, CD56+ CD57+ T cells and CD56− CD57+ T cells
Takayama, E., Koike, Y., Ohkawa, T., Majima, T., Fukasawa, M., Shinomiya, N., Yamaguchi, T., Konishi, M., Hiraide, H., Tadakuma, T., et al. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01575.x · Cited by 40
Preferential Th1 Cytokine Profile of Phosphoantigen-Stimulated Human Vγ9Vδ2 T Cells
Dunne, M. R., Mangan, B. A., Madrigal-Estebas, L., & Doherty, D. G. (2010) · Mediators of Inflammation · doi:10.1155/2010/704941 · Cited by 40
Self-citation
Detection and Characterization of Hemopoietic Stem Cells in the Adult Human Small Intestine
Lynch, L., O’Donoghue, D., Dean, J., O'Sullivan, J. N., O’Farrelly, C., & Golden‐Mason, L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5199 · Cited by 41
Self-citation
Necroinflammatory Liver Disease in BALB/c Background, TGF-β1-Deficient Mice Requires CD4+ T Cells
Rudner, L. A., Lin, J. T., Park, I., Cates, J., Dyer, D. A., Franz, D., French, M. A., Duncan, E. M., White, H. D., & Gorham, J. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4785 · Cited by 40
Autoreactive CD1b-restricted T cells: a new innate-like T-cell population that contributes to immunity against infection
Li, S., Choi, H.-J., Felio, K., & Wang, C.-R. (2011) · Blood · doi:10.1182/blood-2011-03-341941 · Cited by 39
Virological analysis and phenotypic characterization of peripheral blood lymphocytes of hepatitis C virus-infected patients with and without mixed cryoglobulinaemia
Sansonno, D. E., Lauletta, G., Montrone, M., Tucci, F. A., Nisi, L., & Dammacco, F. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02987.x · Cited by 39
Infiltration of invariant natural killer T cells occur and accelerate brain infarction in permanent ischemic stroke in mice
Wang, Z.-K., Li, X., Wang, T., Wang, X., & Su, Z. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.09.010 · Cited by 38
Isolation, purification and flow cytometric analysis of human intrahepatic lymphocytes using an improved technique
Morsy, M. A., Norman, P. J., Mitry, R. R., Rela, M., Heaton, N. D., & Vaughan, R. W. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700219 · Cited by 38
Immunological alterations in newly diagnosed primary Sjögren's syndrome characterized by skewed peripheral T‐cell subsets and inflammatory cytokines
Szodoray, P., Gál, I., Baráth, S., Aleksza, M., Horváth, I. F., Gergely, P., Szegedi, G., Nakken, B., & Zeher, M. (2008) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740801910361 · Cited by 38
Decidual Lymphocytes of Human Spontaneous Abortions Induce Apoptosis but Not Necrosis in JEG-3 Extravillous Trophoblast Cells1
Olivares, E. G., Muñoz, R., Tejerizo, G., Montes, M. J., Gómez-Molina, F., & Abadía‐Molina, A. C. (2002) · Biology of Reproduction · doi:10.1095/biolreprod67.4.1211 · Cited by 38
Lymphocyte recruitment to the liver in alcoholic liver disease
Haydon, G. H., Lalor, P. F., Hübscher, S. G., & Adams, D. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00208-2 · Cited by 38
Chemokine receptors support infiltration of lymphocyte subpopulations in human hepatocellular carcinoma
Liu, Y., Poon, R. T. P., Hughes, J., Feng, X., Yu, W. C., & Fan, S. T. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.10.006 · Cited by 37
Characterization of the inflammatory cell infiltrate and expression of costimulatory molecules in chronic echinococcus granulosus infection of the human liver
Vatankhah, A., Halász, J., Piurkó, V., Barbai, T., Rásó, E., & Tı́már, J. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-1252-x · Cited by 37
Simultaneous expression of th1 cytokines and IL-4 confers severe characteristics to type I autoimmune hepatitis in children
Cherñavsky, A. C., Paladino, N., Rubio, A. E., Biasio, M. B. D., Períolo, N., Cuarterolo, M. L., Goñi, J., Galoppo, C., Cañero-Velasco, M. C., Muñoz, A., et al. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.03.004 · Cited by 37
Peripheral Blood Mononuclear Cells Immunophenotyping in Pulmonary Tuberculosis Patients before and after Treatment
Barcelos, W., Martins‐Filho, O. A., Guimarães, T. M. P. D., Oliveira, M. H. P., de Miranda, S. S., Carvalho, B. N., & de Toledo, V. D. P. C. P. (2006) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2006.tb03834.x · Cited by 37
Hepatic inflammation and immunity: A summary of a conference on the function of the immune system within the liver
Bertolino, P., Klimpel, G. R., & Lemon, S. M. (2000) · Hepatology · doi:10.1053/jhep.2000.8376 · Cited by 37
Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts
Zhang, I. W., López‐Vicario, C., Duran‐Güell, M., & Clària, J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.772174 · Cited by 37
Immune Control in Hepatocellular Carcinoma Development and Progression: Role of Stromal Cells
Sprinzl, M. F., & Galle, P. R. (2014) · Seminars in Liver Disease · doi:10.1055/s-0034-1394138 · Cited by 36
PD-1 blockade improves the anti-tumor potency of exhausted CD3 + CD56 + NKT-like cells in patients with primary hepatocellular carcinoma
Tao, L., Wang, S., Kang, G., Jiang, S., Yin, W., Zong, L., Li, J., & Wang, X. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.2002068 · Cited by 36
Isolation of murine hepatic lymphocytes using mechanical dissection for phenotypic and functional analysis of NK1.1+cells
Dong, Z. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i13.1928 · Cited by 36
Identification of a FOXP3+CD3+CD56+ population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma
Li, X., Peng, J., Pang, Y., Yu, S., Yu, X., Chen, P., Wang, W., Han, W., Zhang, J., Yin, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep14757 · Cited by 34
Identification of a distinct NK-like hepatic T-cell population activated by NKG2C in a TCR-independent manner
Koh, J., Rha, M., Choi, S. J., Lee, H. S., Han, J. W., Nam, H., Kim, D.-U., Lee, J. G., Kim, M. S., Park, J. Y., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.05.020 · Cited by 33
Cytokine-Activated Natural Killer Cells Exert Direct Killing of Hepatoma Cells Harboring Hepatitis C Virus Replicons
Larkin, J. D., Bost, A. G., Glass, J. I., & Tan, S. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.854 · Cited by 34
CD56 Marks an Effector T Cell Subset in the Human Intestine
Cohavy, O., & Targan, S. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5524 · Cited by 34
Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy
Norris, S., Doherty, D. G., Curry, M., McEntee, G., Traynor, O., Hegarty, J. E., & O’Farrelly, C. (2003) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-002-0331-1 · Cited by 34
Self-citation
NK Cells Suppress Experimental Cholestatic Liver Injury by an Interleukin-6-mediated, Kupffer Cell-dependent Mechanism
Cheng, C.-W., Duwaerts, C. C., van Rooijen, N., Wintermeyer, P., Mott, S., & Gregory, S. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.07.018 · Cited by 31
Having it all? Stem cells, haematopoiesis and lymphopoiesis in adult human liver
Golden‐Mason, L., & O’Farrelly, C. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01066.x · Cited by 33
Self-citation
NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?
Stary, V., & Stary, G. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00208 · Cited by 31
Molecular pathogenesis of T lymphocyte-induced liver injury in alcoholic hepatitis
Batey, R. G. (2002) · Frontiers in bioscience · doi:10.2741/a870 · Cited by 32
Simultaneous evaluation of lymphocyte subpopulations in the liver and in peripheral blood mononuclear cells of HCV-infected patients: relationship with histological lesions
Pernollet, M., Jouvin‐Marche, E., Leroy, V., Vigan-Womas, I., Zarski, J., & Marche, P. N. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01996.x · Cited by 32
Upregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin Users
Ye, L., Wang, X., Metzger, D. S., Riedel, E., Montaner, L. J., & Ho, W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009602 · Cited by 32
Animal models of autoimmune liver disease
Peters, M. G. (2002) · Immunology and Cell Biology · doi:10.1046/j.0818-9641.2001.01059.x · Cited by 31
Selective decrease in colonic CD56+ T and CD161+ T cells in the inflamed mucosa of patients with ulcerative colitis
Shimamoto, M., Ueno, Y., Tanaka, S., Onitake, T., Hanaoka, R., Yoshioka, K., Hatakeyama, T., & Chayama, K. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.13.5995 · Cited by 30
Basic Tetrapeptides as Potent Intracellular Inhibitors of Type A Botulinum Neurotoxin Protease Activity
Hale, M. L., Oyler, G. A., Swaminathan, S., & Ahmed, S. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.146464 · Cited by 28
Natural killer cells in hepatitis B virus infection
Wu, S.-F., Wang, W., & Gao, Y. (2015) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2015.05.006 · Cited by 28
Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing
Liu, H., Zhao, R., Qin, R., Sun, H., Huang, Q., Liu, L., Tian, Z., Nashan, B., Sun, C., & Sun, R. (2022) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0050 · Cited by 27
Combinational IL-2/IL-15 induction does not further enhance IL-15-induced lymphokine-activated killer cell cytotoxicity against human leukemia/lymphoma cells
OZDEMIR, O., & Savaşan, S. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.01.008 · Cited by 27
Host–virus interactions in hepatitis B and hepatitis C infection
Yoshio, S., & Kanto, T. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1183-3 · Cited by 28
Natural Killer Cells in Liver Disease
Stegmann, K. A., Easom, N. J. W., Maini, M. K., & Male, V. H. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1603946 · Cited by 27
Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: Implications for hepatic anti-tumour immunity
KELLY, A., Golden‐Mason, L., Traynor, O., Geoghegan, J., McEntee, G., HEGARTY, J., & O’Farrelly, C. (2006) · Cytokine · doi:10.1016/j.cyto.2006.07.019 · Cited by 27
Self-citation
Trafficking of recirculating lymphocytes in the rat liver: rapid transmigration into the portal area and then to the hepatic lymph
Xu, X., Ueta, H., Shu, Z., Shi, C., Koga, D., Ushiki, T., & Matsuno, K. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01671.x · Cited by 27
Tumor Antigen Pulsed Dendritic Cells Enhance the Cytolytic Activity of Tumor Infiltrating Lymphocytes in Human Hepatocellular Cancer
Friedl, J., Stift, A., Paolini, P., Roth, E., Steger, G. G., Mader, R. M., Jakesz, R., & Gnant, M. (2000) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2000.15.477 · Cited by 27
Amelioration of fumonisin B1 hepatotoxicity in mice by depletion of T cells with anti-Thy-1.2
Sharma, N., He, Q., & Sharma, R. P. (2006) · Toxicology · doi:10.1016/j.tox.2006.03.021 · Cited by 26
Human CD8+ T-Cell Populations That Express Natural Killer Receptors
Koh, J., Kim, D.-U., Moon, B.-H., & Shin, E. (2023) · Immune Network · doi:10.4110/in.2023.23.e8 · Cited by 27
T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases
Pugh, S. A., Harrison, R. J., Primrose, J. M., & Khakoo, S. I. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-180 · Cited by 26
Dendritic cells: regulators of hepatic immunity or tolerance?
Doherty, D. G., & O’Farrelly, C. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(00)00020-9 · Cited by 25
Self-citation
The role of intrahepatic CD8+ T cell trapping and NK1.1+ cells in liver-mediated immune regulation
Shibolet, O., Alper, R., Zolotarov, L., Trop, S., Thalenfeld, B. E., Engelhardt, D., Rabbani, E., & Ilan, Y. (2004) · Clinical Immunology · doi:10.1016/j.clim.2003.12.001 · Cited by 25
Immune responses and immunity in hepatitis C virus infection
Mizukoshi, E., & Rehermann, B. (2001) · Journal of Gastroenterology · doi:10.1007/s005350170001 · Cited by 25
Molecular pathogenesis of T lymphocyte-induced liver injury in alcoholic hepatitis
Robert, G. B. (2002) · Frontiers in bioscience · doi:10.2741/batey · Cited by 24
The role of immune regulation in HBV infection and hepatocellular carcinogenesis
Zheng, H., Xu, B., Fan, Y., Tuekprakhon, A., Stamataki, Z., & Wang, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1506526 · Cited by 26
Expression of Inhibitory Receptors in Natural Killer (CD3−CD56+) Cells and CD3+CD56+ Cells in the Peripheral Blood Lymphocytes and Tumor Infiltrating Lymphocytes in Patients with Primary Hepatocellular Carcinoma
Yuen, M., & Norris, S. (2001) · Clinical Immunology · doi:10.1006/clim.2001.5110 · Cited by 23
Self-citation
Differentiation-dependent and subset-specific recruitment of T-helper cells into murine liver
Klugewitz, K., Topp, S. A., Dahmen, U., Kaiser, T., Sommer, S., Kury, E., & Hamann, A. (2002) · Hepatology · doi:10.1053/jhep.2002.31310 · Cited by 23
Mechanisms of Superior Anti-Tumor Cytotoxic Response of Interleukin 15-Induced Lymphokine-Activated Killer Cells
zdemir, N., Ravindranath, Y., & Sava??an, S. (2004) · Journal of Immunotherapy · doi:10.1097/00002371-200501000-00006 · Cited by 23
HLA-C Matching and Liver Transplants: Donor-Recipient Genotypes Influence Early Outcome and CD8+KIR2D+ T-Cells Recuperation
López-Álvarez, M. R., Moya‐Quiles, M. R., Minguela, A., Gil, J., Miras, M., Campillo, J. A., Díaz-Alderete, M. A., García-Alonso, A. M., Bueno, F. S., Vicario, J. L., et al. (2009) · Transplantation · doi:10.1097/tp.0b013e3181af7d84 · Cited by 22
Role of the Liver in Peripheral Tolerance: Induction Through Oral Antigen Feeding
Li, W., Chou, S. T., Wang, C., Kuhr, C. S., & Perkins, J. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00551.x · Cited by 26
The spectrum of lymphoid subsets preferentially recruited into the liver reflects that of resident populations
Klugewitz, K., Blumenthal-Barby, F., Eulenburg, K., Emoto, M., & Hamann, A. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.03.007 · Cited by 22
Human Hepatic CD56bright NK Cells Display a Tissue-Resident Transcriptional Profile and Enhanced Ability to Kill Allogenic CD8+ T Cells
Jameson, G., Harmon, C., Santiago, R. M., Houlihan, D. D., Gallagher, T. K., Lynch, L., Robinson, M. W., & O’Farrelly, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.921212 · Cited by 22
Self-citation
Immunosuppressive roles of natural killer T (NKT) cells in the skin
McKee, S. J., Mattarollo, S. R., & Leggatt, G. R. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.4ru0114-001r · Cited by 21
The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis
Podbielska, M., Levery, S. B., & Hogan, E. L. (2011) · Clinical Lipidology · doi:10.2217/clp.11.8 · Cited by 21
Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus
Miyaki, E., Hiraga, N., Imamura, M., Uchida, T., Kan, H., Tsuge, M., Abe‐Chayama, H., Hayes, C. N., Makokha, G. N., Serikawa, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172412 · Cited by 21
Adoptive transfer of NK 1.1+ lymphocytes in immune-mediated colitis: a pro-inflammatory or a tolerizing subgroup of cells?
Menachem, Y., Trop, S., Kolker, O., Shibolet, O., Alper, R., Nagler, A., & Ilan, Y. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.03.019 · Cited by 21

Authors: Doherty, D. G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J. E., & O’Farrelly, C.
Affiliations: University College Dublin (IE)
St. Vincent's University Hospital (IE)
Corresponding author: Norris, Suzanne
ORCID: Doherty, Derek G
Norris, Suzanne
O’Farrelly, Cliona
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1999-08
Volume: 163
Issue: 4
Pages: 2314-2321
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.163.4.2314
OpenAlex: W2139250003
Cited by: 350
References: 53
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 15 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 11 · 2012: 7
FWCI: 6.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords: hepatic lymphocytes, natural killer cells, T cells, CD3+CD56+ cells, cytotoxicity, cytokine production, Th1 cytokines, Th2 cytokines, interleukin-2, interferon-gamma, TNF-α, IL-4, γδ T cells, innate immunity, liver
MeSH terms: Adult, Cell Separation, Cells, Cultured, Cytotoxicity, Immunologic, Humans, Killer Cells, Natural, Liver, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic, Killer Cells, Lymphokine-Activated, Lymphocyte Subsets, Cytokines, CD3 Complex, Th1 Cells, Th2 Cells, CD56 Antigen

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks