The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns
Open accessAbstract
The human liver contains significant numbers of T cells, NK cells, and lymphocytes that coexpress T and NK cell receptors. To evaluate their functional activities, we have compared the cytotoxic activities and cytokines produced by normal adult hepatic CD3+CD56− (T) cells, CD3−CD56+ (NK) cells, and CD3+CD56+ (natural T (NT)) cells. In cytotoxicity assays using immunomagnetic bead-purified NK cell, T cell, and NT cell subpopulations as effectors, fresh hepatic NK cells lysed K562 targets, while NT cells could be induced to do so by culturing with IL-2. Both NT and T cells were capable of redirected cytolysis of P815 cells using Abs to CD3. Flow cytometric analysis of cytokine production by fresh hepatic lymphocyte subsets activated by CD3 cross-linking or PMA and ionomycin stimulation indicated that NT cells and T cells could produce IFN-γ, TNF-α, IL-2, and/or IL-4, but little or no IL-5, while NK cells produced IFN-γ and/or TNF-α only. The majority of NT cells produced inflammatory (Th1) cytokines only; however, ∼6% of all hepatic T cells, which included 5% of Vα24 TCR-bearing NT cells and 2% of γδTCR+ cells, simultaneously produced IFN-γ and IL-4. The existence of such large numbers of cytotoxic lymphocytes with multiple effector functions suggests that the liver is an important site of innate immune responses, early regulation of adaptive immunity, and possibly peripheral deletion of autologous cells.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“NKs represent the largest population of lymphocytes in the liver(72, 73).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [73]
Citations
Cites
Functional diversity of helper T lymphocytes
Abbas, A. K., MURPHY, K. M. M., & Sher, A. (1996) · Nature · doi:10.1038/383787a0 · Cited by 4,432
CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400
Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M. (1997) · Science · doi:10.1126/science.278.5343.1623 · Cited by 1,237
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
Groh, V., Steinle, A., Bauer, S., & Spies, T. A. (1998) · Science · doi:10.1126/science.279.5357.1737 · Cited by 1,142
Lantz, O. J., & Bendelac, A. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,036
Recognition of a lipid antigen by CD1-restricted αβ+ T cells
Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994) · Nature · doi:10.1038/372691a0 · Cited by 977
CD1 Recognition by Mouse NK1 + T Lymphocytes
Bendelac, A. S., Lantz, O. J., Quimby, M. E., Yewdell, J. W., Bennink, J. R., & Brutkiewicz, R. R. (1995) · Science · doi:10.1126/science.7538697 · Cited by 912
CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens
Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T. T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., et al. (1995) · Science · doi:10.1126/science.7542404 · Cited by 727
Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes
Wilson, S. B., Kent, S. C., Patton, K. T., Orban, T., Jackson, R. A., Exley, M. A., Porcelli, S. A., Schatz, D., Atkinson, M. A., Balk, S. P., et al. (1998) · Nature · doi:10.1038/34419 · Cited by 646
Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P., & Kronenberg, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.8.1521 · Cited by 642
Research works printed but not linked: 52
- 1992, Hepatology, 816
- 1998, J. Hepatol., 84
- 1994, J. Exp. Med., 699
- 1997, Hepatology, 301
- 1995, Science, 1845
- 1996, J. Exp. Med., 2391
- 1997, J. Immunol., 2240
- 1994, J. Exp. Med., 1097
- 1995, Science, 863
- 1997, Science, 1626
- 1991, Cell Immunol., 486
- 1994, Eur. J. Immunol., 2294
- 1995, Science, 403
- 1995, Int. Immunol., 697
- 1997, J. Exp. Med., 109
- 1998, J. Exp. Med., 1521
- 1998, J. Exp. Med., 1529
- 1997, J. Immunol., 5862
- 1999, Hum. Immunol., 20
- 1990, J. Immunol., 1039
- 1996, J. Immunol., 3366
- 1997, Science, 1623
- 1995, J. Immunol., 4333
- 1996, Int. Immunol., 1759
- 1997, Eur. J. Immunol., 183
- 1997, Int. Immunol., 73
- 1998, Eur. J. Immunol., 1507
- 1998, J. Immunol., 1239
- 1998, J. Immunol., 3527
- 1991, Hepatology, 495
- 1994, Transplantation, 496
- 1996, J. Immunol., 2436
- 1996, J. Immunol., 3886
- 1995, J. Immunol. Methods, 117
- 1995, Blood, 1408
- 1995, J. Exp. Med., 1357
- 1992, Hepatology, 1112
- 1997, Am. J. Physiol., G322
- 1996, Nature, 787
- 1997, J. Immunol., 3723
- 1989, Nature, 447
- 1990, Eur. J. Immunol., 703
- 1994, Nature, 691
- 1995, Science, 227
- 1994, J. Immunol., 3074
- 1995, J. Exp. Med., 1163
- 1998, Nature, 177
- 1994, Immunity, 741
- 1994, Int. Immunol., 533
- 1991, J. Immunol., 2907
- 1998, Science, 1737
- 1990, Int. J. Cancer, 373
Cited by
Sorted by citations
Liver immunology and its role in inflammation and homeostasis
Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151
Self-citationNKT cells: facts, functions and fallacies
Godfrey, D. I., Hammond, K. J. L., Poulton, L. D., Smyth, M. J., & Baxter, A. G. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01735-7 · Cited by 859
Yuen, M., Chen, D., Dusheiko, G. M., Janssen, H. L. A., Lau, D., LOCARNINI, S. A., Peters, M. G., & Lai, C. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.35 · Cited by 867
Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo
Kakimi, K., Guidotti, L. G., Koezuka, Y., & Chisari, F. V. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.921 · Cited by 584
Living in the liver: hepatic infections
Protzer, U., Maini, M. K., & Knolle, P. A. (2012) · Nature reviews. Immunology · doi:10.1038/nri3169 · Cited by 577
Chew, V., Chen, J., Lee, D., Loh, E., Lee, J., Lim, K. H., Weber, A., Slankamenac, K., Poon, R. T. P., Yang, H. H., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-300509 · Cited by 367
Mechanisms of drug-induced liver injury
Holt, M. R., & Ju, C. (2006) · The AAPS Journal · doi:10.1208/aapsj080106 · Cited by 335
Immunity, tolerance and autoimmunity in the liver: A comprehensive review
Doherty, D. G. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.08.020 · Cited by 322
Self-citationAberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
Adams, D., & Eksteen, B. (2006) · Nature reviews. Immunology · doi:10.1038/nri1784 · Cited by 307
Peripheral CD4+CD8+ T cells are differentiated effector memory cells with antiviral functions
Nascimbeni, M., Shin, E., Chiriboga, L. A., Kleiner, D. E., & Rehermann, B. (2004) · Blood · doi:10.1182/blood-2003-12-4395 · Cited by 263
Peppa, D., Micco, L., Javaid, A., Kennedy, P. T. F., Schurich, A., Dunn, C., Pallant, C., Ellis, G., Khanna, P., Dusheiko, G. M., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001227 · Cited by 263
Lynch, L., O'Shea, D. B., Winter, D. C., Geoghegan, J., Doherty, D. G., & O’Farrelly, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200939349 · Cited by 269
Self-citationFunctional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
Das, A., Hoare, M., Davies, N., Lopes, A. R., Dunn, C., Kennedy, P. T. F., Alexander, G., Finney, H., Lawson, A., Plunkett, F. J., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072076 · Cited by 256
Lalor, P. F., Edwards, S., McNab, G. L., Salmi, M., Jalkanen, S., & Adams, D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.983 · Cited by 237
CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver
Stegmann, K. A., Robertson, F., Hansi, N., Gill, U., Pallant, C., Christophides, T., Pallett, L. J., Peppa, D., Dunn, C., Fusai, G., et al. (2016) · Scientific Reports · doi:10.1038/srep26157 · Cited by 235
Immune-mediated drug-induced liver disease
Liu, Z.-X., & Kaplowitz, N. (2002) · Clinics in Liver Disease · doi:10.1016/s1089-3261(02)00025-9 · Cited by 170
Kita, H., Naidenko, O. V., Kronenberg, M., Ansari, A. A., Rogers, P., He, X.-S., Koning, F., Mikayama, T., de Water, J. V., Coppel, R. L., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.36020 · Cited by 219
Microanatomy of the liver immune system
Németh, E., Baird, A. W., & O’Farrelly, C. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0173-4 · Cited by 216
Self-citationRecruitment of lymphocytes to the human liver
Lalor, P. F., Shields, P. L., Grant, A. J., & Adams, D. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01062.x · Cited by 203
Sun, C., Fu, B., Gao, Y., Liao, X., Sun, R., Tian, Z., & Wei, H. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002594 · Cited by 210
Bogdanos, D. P., Gao, B., & Gershwin, M. E. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120011 · Cited by 231
Nascimbeni, M., Mizukoshi, E., Bosmann, M., Major, M. E., Mihalik, K., Rice, C. M., Feinstone, S. M., & Rehermann, B. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4781-4793.2003 · Cited by 194
Kenna, T., Golden‐Mason, L., Porcelli, S. A., Koezuka, Y., Hegarty, J. E., O’Farrelly, C., & Doherty, D. G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.1775 · Cited by 189
Self-citationIshiyama, K., Ohdan, H., Ohira, M., Mitsuta, H., Arihiro, K., & Asahara, T. (2006) · Hepatology · doi:10.1002/hep.21035 · Cited by 186
Activation of Natural Killer Cells During Acute Infection With Hepatitis C Virus
Amadei, B., Urbani, S., Cazaly, A. M., Fisicaro, P., Zerbini, A., Ahmed, P. S., Missale, G., Ferrari, C. I., & Khakoo, S. I. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.006 · Cited by 185
Dunne, J., Lynch, S., O’Farrelly, C., Todryk, S. M., Hegarty, J. E., Feighery, C., & Doherty, D. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3129 · Cited by 176
Self-citationMacrophages in the Aging Liver and Age-Related Liver Disease
Stahl, E. C., Haschak, M. J., Popovic, B., & Brown, B. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02795 · Cited by 171
Renukaradhya, G. J., Khan, M. A., Vieira, M., Du, W., Gervay‐Hague, J., & Brutkiewicz, R. R. (2008) · Blood · doi:10.1182/blood-2007-05-092866 · Cited by 168
Increase of CD4+CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma
Yang, X. H., Yamagiwa, S., Ichida, T., Matsuda, Y., Sugahara, S., Watanabe, H., Sato, Y., Abo, T., Horwitz, D. A., & Aoyagi, Y. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.01.036 · Cited by 166
The role of innate immunity in the immunopathology and treatment of HBV infection
Maini, M. K., & Gehring, A. J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.028 · Cited by 163
Knapp, S., Warshow, U. M., Hegazy, D., Brackenbury, L. S., Guha, I. N., Fowell, A. J., Little, A., Alexander, G., Rosenberg, W. M., Cramp, M., et al. (2009) · Hepatology · doi:10.1002/hep.23477 · Cited by 157
The lymphoid liver: Considerations on pathways to autoimmune injury
Kita, H., de Water, J. V., Gershwin, M. E., & Mackay, I. R. (2001) · Gastroenterology · doi:10.1053/gast.2001.22441 · Cited by 157
Selective Loss of Innate CD4+Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection
Sandberg, J. K., Fast, N. M., Palacios, E. H., Fennelly, G. J., Dobroszycki, J., Palumbo, P. E., WIZNIA, A. A., Grant, R. M., Bhardwaj, N., Rosenberg, M. G., et al. (2002) · Journal of Virology · doi:10.1128/jvi.76.15.7528-7534.2002 · Cited by 157
Immunology of the healthy liver: Old questions and new insights
Mehal, W. Z., Azzaroli, F., & Crispe, I. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.20947 · Cited by 150
Role of primary intrahepatic T‐cell activation in the ‘liver tolerance effect’
Bertolino, P., Mccaughan, G., & Bowen, D. (2002) · Immunology and Cell Biology · doi:10.1046/j.0818-9641.2001.01048.x · Cited by 162
Mikulak, J., Bruni, E., Oriolo, F., Di Vito, C., & Mavilio, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00946 · Cited by 145
Golden‐Mason, L., Madrigal-Estebas, L., McGrath, E., Conroy, M. J., Ryan, E. J., Hegarty, J. E., O’Farrelly, C., & Doherty, D. G. (2008) · Gut · doi:10.1136/gut.2007.130963 · Cited by 144
Self-citationTo be or not to be NKT: Natural killer T cells in the liver
Exley, M. A., & Koziel, M. J. (2004) · Hepatology · doi:10.1002/hep.20433 · Cited by 143
de Azeredo, E. L., Pinto, L. M. D. O., Zagne, S. M., Cerqueira, D. I., Nogueira, R. M., & Kubelka, C. F. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.02996.x · Cited by 141
Distinct subpopulations of γδ T cells are present in normal and tumor-bearing human liver
Kenna, T., Golden‐Mason, L., Norris, S., Hegarty, J. E., O’Farrelly, C., & Doherty, D. G. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.05.003 · Cited by 138
Self-citationFranceschetti, M., Pievani, A., Borleri, G., Vago, L., Fleischhauer, K., Golay, J., & Introna, M. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.01.010 · Cited by 138
Harmon, C., Robinson, M. W., Fahey, R., Whelan, S., Houlihan, D. D., Geoghegan, J., & O’Farrelly, C. (2016) · European Journal of Immunology · doi:10.1002/eji.201646559 · Cited by 145
Self-citationDrug-induced liver injury: Is it somehow foreseeable?
Tarantino, G., Minno, M. N. D. D., & Capone, D. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.2817 · Cited by 137
Chemokines in the immunopathogenesis of hepatitis C infection #
Heydtmann, M., & Adams, D. (2008) · Hepatology · doi:10.1002/hep.22763 · Cited by 138
Durante‐Mangoni, E., Wang, R., Shaulov, A., He, Q., Nasser, I. A., Afdhal, N. H., Koziel, M. J., & Exley, M. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.2159 · Cited by 133
Minagawa, M., Deng, Q., Liu, Z., Tsukamoto, H., & Dennert, G. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.022 · Cited by 135
Sheu, B., Chiou, S., Lin, H., Chow, S., Huang, S., Ho, H., & Hsu, S.-M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2108 · Cited by 130
Alter, G., Jost, S., Rihn, S. J., Reyor, L. L., Nolan, B. E., Ghebremichael, M. S., Bosch, R. J., Altfeld, M. A., & Lauer, G. M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.11.030 · Cited by 132
Incidence and characteristics of CD4(+)/HLA DRhi dendritic cell malignancies.
Bueno, C., Almeida, J., Lúcio, P., Marco, J., García, R., Pablos, J. M. D., Parreira, A., Ramos, F., Ruiz‐Cabello, F., Suárez‐Vilela, D., et al. (2004) · PubMed · Cited by 123
Compromised Function of Natural Killer Cells in Acute and Chronic Viral Hepatitis
Lunemann, S., Malone, D. F. G., Hengst, J., Port, K., Grabowski, J., Deterding, K., Markova, A. A., Bremer, B., Schlaphoff, V., Cornberg, M., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit561 · Cited by 122
Wald, O., Pappo, O., Safadi, R., Dagan‐Berger, M., Beider, K., Wald, H., Franitza, S., Weiss, I. D., Avniel, S., Pal, B., et al. (2004) · European Journal of Immunology · doi:10.1002/eji.200324441 · Cited by 121
Golden‐Mason, L., Cox, A. L., Randall, J. A., Cheng, L., & Rosen, H. R. (2010) · Hepatology · doi:10.1002/hep.23896 · Cited by 117
Cheng, M. L., Nakib, D., Perciani, C. T., & MacParland, S. A. (2021) · Clinical Science · doi:10.1042/cs20190654 · Cited by 130
NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection
Maini, M. K., & Peppa, D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00057 · Cited by 114
Kelly-Rogers, J., Madrigal-Estebas, L., O’Connor, T., & Doherty, D. G. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.08.292 · Cited by 107
Self-citationTrobonjača, Z., Leithäuser, F., Möller, P., Schirmbeck, R., & Reimann, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1413 · Cited by 108
Natural killer T (NKT) cells and their role in antitumor immunity
Brutkiewicz, R. R., & Sriram, V. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00198-6 · Cited by 105
Lucas, M., Gadola, S. D., Meier, U., Young, N. T., Harcourt, G., Karadimitris, A., Coumi, N., Brown, D., Dusheiko, G. M., Cerundolo, V., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.3.2251-2257.2003 · Cited by 103
Xu, C., Mathews, A., Rodrigues, C., Eudy, B. J., Rowe, C. A., O'Donoughue, A., & Percival, S. S. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.11.010 · Cited by 108
Correia, M. P., da Costa, A. V., Uhrberg, M., Cardoso, E. M., & Arosa, F. A. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.09.012 · Cited by 100
Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis
Ahmad, A., & Álvarez, F. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0304197 · Cited by 100
Valsecchi, M. E., Terai, M., Eschelman, D. J., Gonsalves, C. F., Chervoneva, I., Shields, J. A., Shields, C. L., Yamamoto, A., Sullivan, K. L., Laudadio, M., et al. (2015) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2014.11.037 · Cited by 98
Boisvert, J., Kunkel, E. J., Campbell, J. J., Keeffe, E. B., Butcher, E. C., & Greenberg, H. B. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00328-8 · Cited by 98
Deignan, T., Curry, M. P., Doherty, D. G., Golden‐Mason, L., Volkov, Y., Norris, S., Nolan, N. P., Traynor, O., McEntee, G., Hegarty, J. E., et al. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00072-7 · Cited by 98
Self-citationKlugewitz, K., Blumenthal-Barby, F., Schrage, A., Knolle, P., Hamann, A., & Crispe, I. (2002) · Journal of Immunology · doi:10.4049/jimmunol.169.5.2407 · Cited by 108
IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction
Easom, N. J. W., Stegmann, K. A., Swadling, L., Pallett, L. J., Burton, A. R., Odera, D., Schmidt, N. M., Huang, W., Fusai, G., Davidson, B. R., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01009 · Cited by 99
Pár, G., Rukavina, D., Podack, E. R., Horányi, M., Szekeres‐Barthó, J., Hegedűs, G., Paál, M., Szereday, L., Mózsik, G., & Pár, A. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00218-0 · Cited by 97
Ohira, M., Ishiyama, K., Tanaka, Y., Doskali, M., Igarashi, Y., Tashiro, H., Hiraga, N., Imamura, M., Sakamoto, N., Asahara, T., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38374 · Cited by 91
Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?
Lynch, L., Golden‐Mason, L., Eogan, M., O’Herlihy, C., & O’Farrelly, C. (2007) · Human Reproduction · doi:10.1093/humrep/del456 · Cited by 88
Self-citationMoroso, V., Metselaar, H. J., Mancham, S., Tilanus, H. W., Eissens, D., van der Meer, A., van der Laan, L. J. W., Kuipers, E. J., Joosten, I., & Kwekkeboom, J. (2010) · Liver Transplantation · doi:10.1002/lt.22080 · Cited by 88
Florczyk, S. J., Liu, G., Kievit, F. M., Lewis, A. M., Wu, J. D., & Zhang, M. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201100054 · Cited by 85
Unique Aspects of Rejection and Tolerance in Liver Transplantation
Knechtle, S. J., & Kwun, J. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1192058 · Cited by 85
Immunopathogenesis of hepatitis C virus infection
Freeman, A. J., Marinos, G., Ffrench, R. A., & Lloyd, A. R. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.01036.x · Cited by 85
Whalen, M. M., Loganathan, B. G., Yamashita, N., & Saito, T. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(03)00027-9 · Cited by 84
Differentiation of human innate lymphoid cells (ILCs)
Juelke, K., & Romagnani, C. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.11.005 · Cited by 92
Donadon, M., Hudspeth, K. L., Cimino, M., Tommaso, L. D., Preti, M., Tentorio, P., Roncalli, M. G., Mavilio, D., & Torzilli, G. (2017) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-017-3446-6 · Cited by 82
The role of natural killer cells in autoimmune liver disease: A comprehensive review
Hudspeth, K. L., Pontarini, E., Tentorio, P., Cimino, M., Donadon, M., Torzilli, G., Lugli, E., Bella, S. D., Gershwin, M. E., & Mavilio, D. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.07.003 · Cited by 80
Vitelli-Avelar, D. M., Sathler-Avelar, R., Massara, R. L., BORGES, J. D. M., Lage, P. S., de Lana, M., Teixeira‐Carvalho, A., Dias, J. C. P., Elói-Santos, S. M., & Martins‐Filho, O. A. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03123.x · Cited by 80
Schrage, A., Loddenkemper, C., Erben, U., Lauer, U., Hausdorf, G., Jungblut, P. R., Johnson, J. P., Knolle, P. A., Zeitz, M., Hamann, A., et al. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0379-x · Cited by 76
O’Keeffe, J., Doherty, D. G., Kenna, T., Sheahan, K. D., O’Donoghue, D. P., Hyland, J. M., & O’Farrelly, C. (2004) · European Journal of Immunology · doi:10.1002/eji.200424958 · Cited by 77
Self-citationNatural Killer T-like Cells: Immunobiology and Role in Disease
Almeida, J. S., Casanova, J., Santos-Rosa, M., Tarazona, R., Solana, R., & Rodrigues‐Santos, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032743 · Cited by 75
Bozzano, F. M., Picciotto, A., Costa, P., Marras, F., Fazio, V., Hirsch, I., Olive, D., Moretta, L., & Maria, A. D. (2011) · European Journal of Immunology · doi:10.1002/eji.201041361 · Cited by 75
Miyagi, T., Takehara, T., Tatsumi, T., Kanto, T., Suzuki, T., Jinushi, M., Sugimoto, Y., Sasaki, Y., Hori, M., & Hayashi, N. (2003) · International Journal of Cancer · doi:10.1002/ijc.11163 · Cited by 74
CD8+CD28– T cells: Certainties and uncertainties of a prevalent human T‐cell subset
Arosa, F. A. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01057.x · Cited by 73
Donor HLA-C Genotype Has a Profound Impact on the Clinical Outcome Following Liver Transplantation
Hanvesakul, R., Spencer, N., Cook, M. A., Gunson, B. K., Hathaway, M., Brown, R., Nightingale, P., Cockwell, P., Hübscher, S. G., Adams, D., et al. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02341.x · Cited by 73
Chemokines in hepatitis C virus infection: Pathogenesis, prognosis and therapeutics
Wald, O., Weiss, I. D., Galun, E., & Peled, A. (2007) · Cytokine · doi:10.1016/j.cyto.2007.05.013 · Cited by 71
Sajid, M., Liu, L., & Sun, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.887186 · Cited by 71
Cellular Immune Responses against Hepatitis C Virus
Koziel, M. J. (2005) · Clinical Infectious Diseases · doi:10.1086/429492 · Cited by 70
Immunology of the gut and liver: a love/hate relationship
Adams, D., Eksteen, B., & Curbishley, S. M. (2008) · Gut · doi:10.1136/gut.2007.122168 · Cited by 71
Veenstra, H., Baumann, R., Carroll, N. M., Lukey, P. T., Kidd, M., Beyers, N., Bolliger, C. T., van Helden, P. D., & Walzl, G. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03144.x · Cited by 70
NK cells can generate from precursors in the adult human liver
Moroso, V., Famili, F., Papazian, N., Cupedo, T., van der Laan, L. J. W., Geert Kazemier, M., Metselaar, H. J., & Kwekkeboom, J. (2011) · European Journal of Immunology · doi:10.1002/eji.201141760 · Cited by 72
Clinical features of COVID‐19 convalescent patients with re‐positive nucleic acid detection
Zhu, H., Fu, L., Jin, Y., Shao, J., Zhang, S., Zheng, N., Fan, L., Yu, Z., Ying, J., Hu, Y., et al. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23392 · Cited by 67
Regulation of antitumour immunity by CD1d-restricted NKT cells
Swann, J. B., Crowe, N. Y., Hayakawa, Y., Godfrey, D. I., & Smyth, M. J. (2004) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2004.01254.x · Cited by 66
Koreck, A., Surányi, A., Szóny, B. J., Farkas, Á., Bata‐Csörgõ, Z., Kemény, L. V., & DOBOZY, A. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01721.x · Cited by 65
Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus
Kis, J. T., Engelmann, P., Farkas, K., Richman, G., Eck, S., Lolley, J., Jalahej, H., Borowiec, M., Kent, S. C., Treszl, A., et al. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1106654 · Cited by 66
Pascut, D., Pratama, M. Y., Võ, N. V. T., Masadah, R., & Tiribelli, C. (2020) · Cancers · doi:10.3390/cancers12040823 · Cited by 63
Yoon, S. K., Seo, Y. B., Im, S. J., Bae, S. H., Song, D. S., You, C. R., Jang, J., Yang, S. H., Suh, Y. S., Song, J. S., et al. (2014) · Liver International · doi:10.1111/liv.12530 · Cited by 62
Hodgson, P. D., & Michalak, T. I. (2001) · Hepatology · doi:10.1053/jhep.2001.29004 · Cited by 62
Basic concepts in transplant immunology
Martinez, O. M., & Rosen, H. R. (2005) · Liver Transplantation · doi:10.1002/lt.20406 · Cited by 60
Metadata
- Authors
- Doherty, D. G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J. E., & O’Farrelly, C.
- Affiliations
- University College Dublin (IE)
- St. Vincent's University Hospital (IE)
- Corresponding author
- Norris, Suzanne
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 163
- Issue
- 4
- Pages
- 2314-2321
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2139250003
- Cited by
- 350
- References
- 53
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 15 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 11 · 2012: 7
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- hepatic lymphocytes, natural killer cells, T cells, CD3+CD56+ cells, cytotoxicity, cytokine production, Th1 cytokines, Th2 cytokines, interleukin-2, interferon-gamma, TNF-α, IL-4, γδ T cells, innate immunity, liver
- MeSH terms
- Adult, Cell Separation, Cells, Cultured, Cytotoxicity, Immunologic, Humans, Killer Cells, Natural, Liver, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic, Killer Cells, Lymphokine-Activated, Lymphocyte Subsets, Cytokines, CD3 Complex, Th1 Cells, Th2 Cells, CD56 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review