The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Functional Responses and Costimulator Dependence of Memory CD4+ T Cells
Abstract
To examine the functional characteristics of memory CD4+ T cells, we used an adoptive transfer system to generate a stable population of Ag-specific memory cells in vivo and compared their responses to Ag with those of a similar population of Ag-specific naive cells. Memory cells localized to the spleen and lymph nodes of mice and exhibited extremely rapid recall responses to Ag in vivo, leaving the spleen within 3–5 days of Ag encounter. Unlike their naive counterparts, memory cells produced effector cytokines (IFN-γ, IL-4, IL-5) within 12–24 h of Ag exposure and did not require multiple cycles of cell division to do so. Memory cells proliferated at lower Ag concentrations than did naive cells, were less dependent on costimulation by B7 molecules, and independent of costimulation by CD40. Furthermore, effector cytokine production by memory cells also occurred in the absence of either B7 or CD40 costimulation. Lastly, memory cells were resistant to tolerance induction. Together, these findings suggest that the threshold for activation of memory CD4+ cells is lower than that of naive cells. This would permit memory cells to rapidly express their effector functions in vivo earlier in the course of a secondary immune response, when the levels of Ag and the availability of costimulation may be relatively low.
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2 retracted
RETRACTED: Role of Interleukin 12 and Costimulators in T Cell Anergy In Vivo
Parijs, L. V., Perez, V. L., Biuckians, A., Maki, R. G., London, C. A., & Abbas, A. K. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.1119 · Cited by 70
Self-citationRetractedRole of interleukin 12 and costimulators in T cell anergy in vivo
Parijs, L. V., Perez, V. L., Biuckians, A., Maki, R. G., London, C. A., & Abbas, A. K. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.11194309r · Cited by 67
Self-citationRetractedImmunological memory and protective immunity: understanding their relation
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Helper T Cell Differentiation Is Controlled by the Cell Cycle
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Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, A. B., Williams, M. A., Jones, T. R., Shirasugi, N., Durham, M. M., Kaech, S. M., Wherry, E. J., Onami, T., Lanier, J. G., Kokko, K. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317477 · Cited by 616
Bour‐Jordan, H., Esensten, J. H., Martinez‐Llordella, M., Penaranda, C., Stumpf, M., & Bluestone, J. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01011.x · Cited by 391
Immunological memory in rheumatic inflammation - a roadblock to tolerance induction
Maschmeyer, P., Chang, H.-D., Cheng, Q., Mashreghi, M.-F., Hiepe, F., Alexander, T., & Radbruch, A. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00601-6 · Cited by 40
Metadata
- Authors
- London, C. A., Lodge, M. P., & Abbas, A. K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 164
- Issue
- 1
- Pages
- 265-272
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1647115901
- Cited by
- 314
- References
- 46
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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