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TGF-β1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors
Open accessAbstract
We examined the effect of TGF-β1 on the chemotactic migratory ability of human monocyte-derived dendritic cells (DCs). Treatment of immature DCs with TGF-β1 resulted in increased expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXC chemokine receptor-4 (CXCR-4), which were concomitant with enhanced chemotactic migratory responses to their ligands, RANTES (for CCR-1, CCR-3, and CCR-5), macrophage-inflammatory protein-3α (MIP-3α) (for CCR-6), or stromal cell-derived growth factor-1α (for CXCR-4). Ligation by TNF-α resulted in down-modulation of cell surface expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXCR-4, and the chemotaxis for RANTES, MIP-3α, and stromal cell-derived growth factor-1α, whereas this stimulation up-regulated the expression of CCR-7 and the chemotactic ability for MIP-3β. Stimulation of mature DCs with TGF-β1 also enhanced TNF-α-induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-α-induced expression of CCR-7 and chemotactic migratory ability to MIP-3β. Our findings suggest that TGF-β1 reversibly regulates chemotaxis of DCs via regulation of chemokine receptor expression.
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“Additionally, intestinal DCs can induce Treg cell differentiation through activation of TGF-β, possibly involving cell-intrinsic expression of integrin αvβ8186,187.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [187]
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Cites
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129
The Dendritic Cell System and its Role in Immunogenicity
Steinman, R. M. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001415 · Cited by 4,659
Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells
Nestle, F. O., Alijagic, S., Gilliet, M., Sun, Y., Grabbe, S., Dummer, R., Burg, G., & Schadendorf, D. (1998) · Nature Medicine · doi:10.1038/nm0398-328 · Cited by 2,862
Sallusto, F., Cella, M., Danieli, C., & Lanzavecchia, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.2.389 · Cited by 2,501
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909.909_909_928 · Cited by 2,126
Proliferating dendritic cell progenitors in human blood.
Romani, N., Grüner, S., Brang, D., Kämpgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P. O., Steinman, R. M., & Schuler, G. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.83 · Cited by 1,841
Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells
Hsu, F. J., Benike, C., Fagnoni, F., Liles, T. M., Czerwinski, D., Taidi, B., Engleman, E. G., & Levy, R. (1996) · Nature Medicine · doi:10.1038/nm0196-52 · Cited by 1,804
GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
Caux, C., Dezutter‐Dambuyant, C., Schmitt, D., & Banchereau, J. (1992) · Nature · doi:10.1038/360258a0 · Cited by 1,551
Dieu‐Nosjean, M., Vanbervliet, B., Vicari, A. P., Bridon, J., Oldham, E., Aït‐Yahia, S., Brière, F., Zlotnik, A., Lebecque, S., & Caux, C. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.373 · Cited by 1,424
Activation of human dendritic cells through CD40 cross-linking.
Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., van Kooten, C., Durand, I., & Banchereau, J. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.4.1263 · Cited by 1,317
Research works printed but not linked: 48
- 1991, Annu. Rev. Immunol., 271
- 1988, Blood, 1138
- 1990, J. Exp. Med., 307
- 1992, Science, 383
- 1992, Semin. Immunol., 227
- 1996, J. Exp. Med., 1287
- 1992, Nature, 258
- 1994, J. Exp. Med., 1109
- 1996, Proc. Natl. Acad. Sci. USA, 2588
- 1996, J. Exp. Med., 2411
- 1995, J. Exp. Med., 389
- 1994, J. Exp. Med., 1263
- 1996, J. Immunol., 4363
- 1997, J. Immunol., 2919
- 1994, J. Exp. Med., 83
- 1995, J. Immunol., 5851
- 1996, J. Exp. Med., 695
- 1997, Blood, 909
- 1997, J. Biol. Chem., 13803
- 1997, J. Exp. Med., 165
- 1994, J. Biol. Chem., 7835
- 1997, J. Immunol., 1993
- 1997, Blood, 1379
- 1998, J. Immunol., 3933
- 1997, J. Exp. Med., 837
- 1998, J. Immunol., 1083
- 1998, J. Exp. Med., 373
- 1995, J. Immunol., 4926
- 1998, J. Immunol., 2089
- 1998, Transplantation, 1810
- 1996, J. Immunol., 1499
- 1998, J. Exp. Med., 961
- 1999, J. Immunol., 4567
- 1999, Blood, 1208
- 1999, Blood, 3225
- 1999, Blood, 34
- 1999, Exp. Hematol., 326
- 1999, J. Immunol., 3865
- 1999, J. Immunol., 4464
- 1998, J. Exp. Med., 439
- 1999, Blood, 3610
- 1999, J. Immunol., 1737
- 1999, Blood, 2173
- 1997, Am. J. Respir. Cell Mol. Biol., 326
- 1998, J. Hepatol., 803
- 1998, J. Neuropathol. Exp. Neurol., 385
- 1996, Nat. Med., 52
- 1998, Nat. Med., 328
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Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3810 · Cited by 1,466
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Schutyser, E., Struyf, S., & Damme, J. V. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00049-2 · Cited by 777
Mechanisms and Consequences of Dendritic Cell Migration
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Metadata
- Authors
- Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., & Takahashi, T. A.
- Affiliations
- Institute of Medical Science, The University of Tokyo (JP)
- Japanese Red Cross Society, Japan (JP)
- Corresponding author
- Sato, Katsuaki
- Nagayama, Hitomi
- Enomoto, Makoto
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03-01
- Volume
- 164
- Issue
- 5
- Pages
- 2285-2295
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1483423516
- Cited by
- 152
- References
- 53
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 9
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- TGF-β1, dendritic cells, monocyte-derived dendritic cells, chemotaxis, chemokine receptors, CCR5, CXCR4, RANTES, TNF-α, dendritic cell maturation, receptor down-regulation
- MeSH terms
- Cell Differentiation, Cell Membrane, Cells, Cultured, Chemotaxis, Leukocyte, Dendritic Cells, Humans, Ligands, Monocytes, Tumor Necrosis Factor-alpha, Down-Regulation, Up-Regulation, Immunophenotyping, Transforming Growth Factor beta, Interleukin-10, Macrophage Inflammatory Proteins, Receptors, Chemokine, Receptors, CCR5, Receptors, CXCR4, Chemokines, CC, Receptors, CCR1, Receptors, CCR3, Receptors, CCR6, Receptors, CCR7, Chemokine CCL19, Chemokine CCL20, CCR5 Receptor Antagonists
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