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Cited by 1,804Immunotherapy and Immune ResponsesLymphoma Diagnosis and TreatmentT-cell and B-cell Immunology

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

Hsu, Frank J., Benike, Claudia, Fagnoni, Francesco, Liles, Tina Marie, Czerwinski, Debra, Taidi, Behnaz, Engleman, Edgar G., Levy, Ronald·1996·Nature Medicine
DOI 10.1038/nm0196-52
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Abstract

In this pilot study, we investigated the ability of autologous dendritic cells pulsed ex vivo with tumor-specific idiotype protein to stimulate host antitumor immunity when infused as a vaccine. Four patients with follicular B-cell lymphoma received a series of three or four infusions of antigen-pulsed dendritic cells followed, in each instance, by subcutaneous injections of soluble antigen two weeks later. All patients developed measurable antitumor cellular immune responses. In addition, clinical responses have been measured with one patient experiencing complete tumor regression, a second patient having partial tumor regression, and a third patient resolving all evidence of disease as detected by a sensitive tumor-specific molecular analysis.

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Crossref · 10.1038/nm0196-52

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  • Both the T cell pools of healthy individuals and cancer patients contain T cells that can identify KRAS mutation; after vaccination those T cells can be selectively expanded in tumor patients.

    “Both the T cell pools of healthy individuals and cancer patients contain T cells that can identify KRAS mutation. After vaccination those T cells can be selectively expanded in tumor patients.”

    From Targeting KRAS mutant cancers: from druggable therapy to drug resistance (2022) · cites this paper as [85]

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Authors
Hsu, F. J., Benike, C., Fagnoni, F., Liles, T. M., Czerwinski, D., Taidi, B., Engleman, E. G., & Levy, R.
Affiliations
  • Stanford Medicine (US)
  • Stanford Blood Center (US)
ORCID
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
1996-01-01
Volume
2
Issue
1
Pages
52-58
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm0196-52
OpenAlex
W2086704878
Cited by
1,804
References
40
Citations by year
2026: 5 · 2025: 11 · 2024: 8 · 2023: 21 · 2022: 24 · 2021: 16 · 2020: 28 · 2019: 20 · 2018: 23 · 2017: 32 · 2016: 28 · 2015: 27 · 2014: 31 · 2013: 33 · 2012: 44
FWCI
45.70
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • James S. McDonnell Foundation
  • National Institutes of Health
  • National Cancer Institute (CA 33399, CA 49605-07, P01CA034233, CA 34233, P01CA049605)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
dendritic cell vaccination, autologous dendritic cells, antigen-pulsed dendritic cells, follicular B-cell lymphoma, antitumor immunity, cell-mediated immunity, tumor regression, cancer immunotherapy
MeSH terms
Adult, Antigen-Presenting Cells, Cytotoxicity, Immunologic, Dendritic Cells, Female, Humans, Lymph Nodes, Lymphoma, Follicular, Male, Middle Aged, Pilot Projects, Tomography, X-Ray Computed, Transplantation, Autologous, Vaccination, Lymphoma, B-Cell

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