The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC)
Open accessAbstract
We recently reported the identification of a chemokine (CTACK), which has been renamed CCL27 according to a new systematic chemokine nomenclature. We report that CCL27 binds the previously orphan chemokine receptor GPR-2, as detected by calcium flux and chemotactic responses of GPR-2 transfectants. We renamed this receptor CCR10. Because of the skin-associated expression pattern of CCL27, we focused on the expression of CCL27 and CCR10 in normal skin compared with inflammatory and autoimmune skin diseases. CCL27 is constitutively produced by keratinocytes but can also be induced upon stimulation with TNF-α and IL-1β. CCR10 is not expressed by keratinocytes and is instead expressed by melanocytes, dermal fibroblasts, and dermal microvascular endothelial cells. CCR10 was also detected in T cells as well as in skin-derived Langerhans cells. Taken together, these observations suggest a role for this novel ligand/receptor pair in both skin homeostasis as well as a potential role in inflammatory responses.
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Cites
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CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
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Self-citationRecent Advances in Chemokines and Chemokine Receptors
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Cited by
Involvement of chemokine receptors in breast cancer metastasis
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International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
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Lymphocyte traffic control by chemokines
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Bachelerie, F., Ben-Baruch, A., Burkhardt, A. M., Combadiere, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre-Ulrich, A. H., Locati, M., Luster, A. D., et al. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 850
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Metadata
- Authors
- Homey, B., Wang, W., Soto, H., Buchanan, M. E., Wiesenborn, A., Catron, D., Müller, A., McClanahan, T. K., Dieu-Nosjean, M.-C., Orozco, R., Ruzicka, T., Lehmann, P., Oldham, E., & Zlotnik, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-04-01
- Volume
- 164
- Issue
- 7
- Pages
- 3465-3470
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2162287533
- Cited by
- 332
- References
- 17
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC). https://app.cochat.ai/papers/10.4049/jimmunol.164.7.3465
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- Homey, B., Wang, W., Soto, H., Buchanan, M. E., Wiesenborn, A., Catron, D., Müller, A., McClanahan, T. K., Dieu-Nosjean, M.-C., Orozco, R., Ruzicka, T., Lehmann, P., Oldham, E., & Zlotnik, A. (2000). Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC). The Journal of Immunology. https://doi.org/10.4049/jimmunol.164.7.3465
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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