The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Early Programming of T Cell Populations Responding to Bacterial Infection
Abstract
The duration of infection and the quantity of Ag presented in vivo are commonly assumed to influence, if not determine, the magnitude of T cell responses. Although the cessation of in vivo T cell expansion coincides with bacterial clearance in mice infected with Listeria monocytogenes, closer analysis suggests that control of T cell expansion and contraction is more complex. In this report, we show that the magnitude and kinetics of Ag-specific T cell responses are determined during the first day of bacterial infection. Expansion of Ag-specific T lymphocyte populations and generation of T cell memory are independent of the duration and severity of in vivo bacterial infection. Our studies indicate that the Ag-specific T cell response to L. monocytogenes is programmed before the peak of the innate inflammatory response and in vivo bacterial replication.
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Cites
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Cited by
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
mTOR regulates memory CD8 T-cell differentiation
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575
Memory CD8 T-Cell Differentiation during Viral Infection
Wherry, E. J., & Ahmed, R. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5535-5545.2004 · Cited by 868
Sun, J. C., Williams, M. A., & Bevan, M. J. (2004) · Nature Immunology · doi:10.1038/ni1105 · Cited by 649
Signals required for programming effector and memory development by CD8+ T cells
Mescher, M. F., Curtsinger, J. M., Agarwal, P., Casey, K. A., Gerner, M., Hammerbeck, C. D., Popescu, F., & Xiao, Z. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00382.x · Cited by 601
Metadata
- Authors
- Mercado, R., Vijh, S., Allen, S. E., Kerksiek, K., Pilip, I. M., & Pamer, E. G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-12
- Volume
- 165
- Issue
- 12
- Pages
- 6833-6839
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2141205048
- Cited by
- 477
- References
- 39
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mercado, R., Vijh, S., Allen, S. E., Kerksiek, K., Pilip, I. M., & Pamer, E. G. (2000). Early Programming of T Cell Populations Responding to Bacterial Infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.165.12.6833
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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