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Cited by 465

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

Hajjar, Adeline M, O’Mahony, D Shane, Ozinsky, Adrian, Underhill, David M, Aderem, Alan, Klebanoff, Seymour J, Wilson, Christopher B·2001·The Journal of Immunology
DOI 10.4049/jimmunol.166.1.15
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Abstract

Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a variety of microbes, whereas TLR4 is essential for a complete response to LPSs. We report here that TLR2 transduces the response to phenol-soluble modulin, a factor secreted by Staphylococcus epidermidis. The TLR2-mediated response to this modulin was enhanced by TLR6 but inhibited by TLR1, indicating a functional interaction between these receptors. We also demonstrate that a response to phenol-soluble modulin mediated by TLR2 and TLR6 was more refractory to inhibition by TLR1 than one mediated by TLR2 alone.

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Metadata

Authors
Hajjar, A. M., O’Mahony, D. S., Ozinsky, A., Underhill, D. M., Aderem, A., Klebanoff, S. J., & Wilson, C. B.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2001-01-01
Volume
166
Issue
1
Pages
15-19
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.166.1.15
OpenAlex
W1925757606
Cited by
465
References
1
FWCI
13.65
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.