Cited by 260Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

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Identification, Cloning, and Characterization of a Novel Soluble Receptor That Binds IL-22 and Neutralizes Its Activity

Kotenko, Sergei V, Izotova, Lara S, Mirochnitchenko, Olga V, Esterova, Elena, Dickensheets, Harold, Donnelly, Raymond P, Pestka, Sidney·2001·The Journal of Immunology

DOI 10.4049/jimmunol.166.12.7096

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Abstract

With the use of a partial sequence of the human genome, we identified a gene encoding a novel soluble receptor belonging to the class II cytokine receptor family. This gene is positioned on chromosome 6 in the vicinity of the IFNGR1 gene in a head-to-tail orientation. The gene consists of six exons and encodes a 231-aa protein with a 21-aa leader sequence. The secreted mature protein demonstrates 34% amino acid identity to the extracellular domain of the IL-22R1 chain. Cross-linking experiments demonstrate that the protein binds IL-22 and prevents binding of IL-22 to the functional cell surface IL-22R complex, which consists of two subunits, the IL-22R1 and the IL-10R2c chains. Moreover, this soluble receptor, designated IL-22-binding protein (BP), is capable of neutralizing IL-22 activity. In the presence of the IL-22BP, IL-22 is unable to induce Stat activation in IL-22-responsive human lung carcinoma A549 cells. IL-22BP also blocked induction of the suppressors of cytokine signaling-3 (SOCS-3) gene expression by IL-22 in HepG2 cells. To further evaluate IL-22BP action, we used hamster cells expressing a modified IL-22R complex consisting of the intact IL-10R2c and the chimeric IL-22R1/γR1 receptor in which the IL-22R1 intracellular domain was replaced with the IFN-γR1 intracellular domain. In these cells, IL-22 activates biological activities specific for IFN-γ, such as up-regulation of MHC class I Ag expression. The addition of IL-22BP neutralizes the ability of IL-22 to induce Stat activation and MHC class I Ag expression in these cells. Thus, the soluble receptor designated IL-22BP inhibits IL-22 activity by binding IL-22 and blocking its interaction with the cell surface IL-22R complex.

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
Proinflammatory Cytokines
Dinarello, C. A. (2000) · CHEST Journal · doi:10.1378/chest.118.2.503 · Cited by 2,047
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis
Barnstable, C. J. (1978) · Cell · doi:10.1016/0092-8674(78)90296-9 · Cited by 1,928
Translator's Introduction
Shields, M. K. (2001) · Method Journal of Lonergan Studies · doi:10.5840/method20011916 · Cited by 750
The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning
Novick, D. (1994) · Cell · doi:10.1016/0092-8674(94)90154-6 · Cited by 671
A novel IL‐1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.
McMahan, C. J., Slack, J. L., Mosley, B., Cosman, D. J., Lupton, S., Brunton, L. L., Grubin, C. E., Wignall, J. M., Jenkins, N. A., & Brannan, C. I. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07831.x · Cited by 668
Signaling Through the Hematopoietic Cytokine Receptors
Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., & Silvennoinen, O. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002101 · Cited by 612
Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R
Xie, M.-H., Aggarwal, S., Ho, W.-H., Foster, J., Zhang, Z., Stinson, J., Wood, W. I., Goddard, A. D., & Gurney, A. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005304200 · Cited by 570
Interleukin 20
Blumberg, H., Conklin, D., Xu, W., Grossmann, A., Brender, T., Carollo, S., Eagan, M., Foster, D., Haldeman, B. A., Hammond, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00187-8 · Cited by 542
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
Kotenko, S. V., Saccani, S., Izotova, L. S., Mirochnitchenko, O. V., & Pestka, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1695 · Cited by 519
Self-citation

Flagged first, then by citations

Show all 32 references

Research works printed but not linked: 31

1994, Science, 1415
1995, Annu. Rev. Immunol., 369
2000, Oncogene, 2557
1997, Cytokine Growth Factor Rev., 189
1991, EMBO J., 2821
1994, Cell, 391
1999, Methods, 121
2000, Chest, 503
2000, Curr. Opin. Immunol., 59
2000, J. Interferon Cytokine Res., 843
1995, J. Biol. Chem., 21606
1996, J. Biol. Chem., 17174
1999, Proc. Natl. Acad. Sci. USA, 5007
1995, EMBO J., 5100
1997, J. Biol. Chem., 11002
2001, Blood, 473
2001, J. Biol. Chem., 2725
2000, J. Biol. Chem., 31335
1997, EMBO J., 5894
2000, Proc. Natl. Acad. Sci. USA, 1695
1993, Proc. Natl. Acad. Sci. USA, 8737
1978, Cell, 9
1995, J. Biol. Chem., 20915
1989, Proc. Natl. Acad. Sci. USA, 558
1999, Protein Expression Purif., 203
2001, Cell, 9
2000, Proc. Natl. Acad. Sci. USA, 10144
2000, J. Immunol., 1814
1995, Oncogene, 2477
2000, Genes Immun., 442
2000, J. Virol., 3881

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Structure of Interleukin-10/Interleukin-10R1 Complex: A Paradigm for Class 2 Cytokine Activation
Walter, M. R. (2002) · Immunologic Research · doi:10.1385/ir:26:1-3:303 · Cited by 17
IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1
Hebert, K., Mclaughlin, N., Zhang, Z., Cipriani, A., Alcorn, J. F., & Pociask, D. A. (2019) · Respiratory Research · doi:10.1186/s12931-019-1153-4 · Cited by 16
Temporal overexpression of IL‐22 and Reg3γ differentially impacts the severity of experimental autoimmune encephalomyelitis
Eken, A., Erdem, Ş., Haliloğlu, Y., Okuş, F. Z., Çakır, M., Yetkin, M. F., Akçakoyunlu, M., Karayığıt, M. Ö., Azizoğlu, Z. B., Biçer, A., et al. (2021) · Immunology · doi:10.1111/imm.13340 · Cited by 16
Interleukin‐22 and Its Crystal Structure
Nagem, R. A. P., Ferreira-Júnior, J. R., Dumoutier, L., Renauld, J., & Polikarpov, I. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74004-3 · Cited by 16
Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival
Karstens, K.-F., Kempski, J., Giannou, A. D., Pelczar, P., Steglich, B., Steurer, S. A., Freiwald, E., Woestemeier, A., Konczalla, L., Tachezy, M., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02517-8 · Cited by 16
Rationalizing heptadecaphobia: TH17 cells and associated cytokines in cancer and metastasis
Lücke, J., Shiri, A. M., Zhang, T., Kempski, J., Giannou, A. D., & Huber, S. (2021) · FEBS Journal · doi:10.1111/febs.15711 · Cited by 14
Opportunities and challenges: interleukin-22 comprehensively regulates polycystic ovary syndrome from metabolic and immune aspects
Geng, Y., Liu, Z., Hu, R., Ma, W., Wu, X., Dong, H., Song, K., Xu, X., Huang, Y., Li, F., et al. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01236-9 · Cited by 15
Suppressors of cytokine signaling proteins in innate and adaptive immune responses.
Dalpke, A. H., & Heeg, K. M. (2003) · PubMed · Cited by 14
Altered serum profile of the interleukin-22 system in inflammatory bowel disease
Sakemi, R., Mitsuyama, K., Morita, M., Yoshioka, S., Kuwaki, K., Tokuyasu, H., Fukunaga, S., Mori, A., Araki, T., Yoshimura, T., et al. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155264 · Cited by 13
Interleukin-10
Ding, Y., Fu, S., Zamarin, D., & Bromberg, J. S. (2003) · Elsevier eBooks · doi:10.1016/b978-012689663-3/50029-6 · Cited by 13
Delivery of interleukin-22 binding protein (IL-22BP) gene by cationic micelle for colon cancer gene therapy
Men, K., Huang, R., Zhang, X.-Y., Zhang, R., Zhang, Y., Peng, Y., Tong, R.-S., Yang, L., Wei, Y.-Q., & Duan, X. (2018) · RSC Advances · doi:10.1039/c8ra02580k · Cited by 7
Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders
Gu, J., Zhou, P., Liu, Y., Xu, Q., Chen, X., Chen, M., Chen, L., Qu, C., Tong, Y., Yu, Q., et al. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111776 · Cited by 13
Functional and molecular factors associated with TAPSE in hypoxic pulmonary hypertension
Crnković, S., Schmidt, A. G., Egemnazarov, B., Wilhelm, J., Marsh, L. M., Ghanim, B., Klepetko, W., Olschewski, A., Olschewski, H., & Kwapiszewska, G. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00381.2015 · Cited by 12
Interleukin-22, a potent target for treatment of non-autoimmune diseases
Zheng, Y., & Li, T. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1509649 · Cited by 12
Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response
Gómez-Fernández, P., Urtasun, A., Paton, A. W., Paton, J. C., Borrego, F., Dersh, D., Argon, Y., Alloza, I., & Vandenbroeck, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02934 · Cited by 11
Structural Studies of the Interleukin‐19 Subfamily of Cytokines
Zdanov, A. S. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74003-1 · Cited by 12
Interleukin-22 and acute pancreatitis: A review
Fu, X., Xiu, Z., & Xu, H. (2023) · Medicine · doi:10.1097/md.0000000000035695 · Cited by 11
IL-22 Binding Protein Controls IL-22–Driven Bleomycin-Induced Lung Injury
Zhang, Z., Chakawa, M., Galeas‐Pena, M., Frydman, J. A., Allen, M. J., Jones, M., & Pociask, D. A. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.11.011 · Cited by 12
A novel transcript of mouse interleukin-20 receptor acts on glomerular mesangial cells as an aggravating factor in lupus nephritis
Wei, C.-C., & Chang, M.-S. (2008) · Genes and Immunity · doi:10.1038/gene.2008.61 · Cited by 11
Increased Urinary Interleukin 22 Binding Protein Levels Correlate with Lupus Nephritis Activity
Yang, X., Gao, Y., Wang, H., Zhao, X., Gong, X., Wang, Q., & Zhang, X. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.131292 · Cited by 11
Colonizing Microbes, IL-10 and IL-22: Keeping the Peace at the Mucosal Surface
Kidess, E., Kleerebezem, M., & Brugman, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.729053 · Cited by 11
Role of SOCS and VHL Proteins in Neuronal Differentiation and Development
Kanno, H., Matsumoto, S., Yoshizumi, T., Nakahara, K., Kubo, A., Murata, H., Shuin, T., & Hoi-Sang, U. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043880 · Cited by 9
Interleukin-22 protects rat PC12 pheochromocytoma cells from serum deprivation-induced cell death
Liu, Y., Pan, W., Yang, S., Wu, X., Wu, J., Ma, J., Yuan, Z., & Meng, S. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1430-8 · Cited by 9
Genomic structure and inducible expression of the IL-22 receptor α chain in mice
Tachiiri, A., Imamura, R., Wang, Y., Fukui, M., Umemura, M., & Suda, T. (2003) · Genes and Immunity · doi:10.1038/sj.gene.6363934 · Cited by 8
The double-edged role of IL-22 in organ fibrosis
Chen, J., Lodi, R., Zhang, S., Su, Z., Wu, Y., & Xia, L. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1799388 · Cited by 8
Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
Furue, M., & Furue, M. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00005 · Cited by 10
Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to the extracellular IL-22R1 chain
Jones, B. C., Logsdon, N. J., & Walter, M. R. (2008) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309108004752 · Cited by 8
Increased IL-22 in cerebrospinal fluid of neuro-behçet’s disease patients
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Authors: Kotenko, S. V., Izotova, L. S., Mirochnitchenko, O. V., Esterova, E., Dickensheets, H., Donnelly, R. P., & Pestka, S.
Affiliations: Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry, Robert Wood Johnson Medical School , Piscataway, NJ 08854
Center for Biologics Evaluation and Research (US)
ORCID: Kotenko, Sergei V
Donnelly, Raymond P
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2001-06
Volume: 166
Issue: 12
Pages: 7096-7103
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.166.12.7096
OpenAlex: W1938903801
Cited by: 260
References: 32
Citations by year: 2026: 1 · 2025: 3 · 2024: 10 · 2023: 12 · 2022: 6 · 2021: 15 · 2020: 16 · 2019: 10 · 2018: 19 · 2017: 11 · 2016: 14 · 2015: 12 · 2014: 11 · 2013: 12 · 2012: 10
FWCI: 7.06
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (1P30-CA72720, R01 CA-46465, R01CA046465, P30CA072720)
National Institute of Allergy and Infectious Diseases (R01-AI43369, R01-AI36450, R01AI043369, R01AI036450)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: soluble receptor, IL-22, STAT activation, SOCS3, MHC class I expression, IFNGR1, chromosome 6, gene cloning
MeSH terms: Interleukin-22, Amino Acid Sequence, Animals, Base Sequence, Binding, Competitive, Carrier Proteins, Cloning, Molecular, Cricetinae, Humans, Interleukins, Ligands, Molecular Sequence Data, Receptors, Cell Surface, Solubility, Tumor Cells, Cultured, CHO Cells, DNA, Complementary, Receptors, Interleukin, COS Cells

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Identification, Cloning, and Characterization of a Novel Soluble Receptor That Binds IL-22 and Neutralizes Its Activity

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