Role of IL-22 in homeostasis and diseases of the skin
Open accessAbstract
Interleukin-22 (IL-22) is a cytokine mainly produced by T cells and innate lymphoid cells (ILC). IL-22 primarily targets non-hematopoietic cells such as epithelial cells and fibroblasts. In the skin, IL-22 promotes the proliferation of keratinocytes and dermal fibroblasts. IL-22 furthermore regulates innate immune responses as it induces the production of antimicrobial proteins and neutrophil-attracting chemokines. IL-22 plays an important role in wound healing and in the protection against skin infections. However, IL-22 can also contribute to the pathogenesis of several inflammatory skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis. In this review, current information regarding the structure, function and regulation of IL-22 is discussed with a special focus on the role of IL-22 in the skin and in skin diseases.
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Neutrophils migrate into the epidermis in response to keratinocyte-derived chemokines, forming characteristic microabscesses (Munro abscesses) and contributing to inflammation through proteases, reactive oxygen species, and extracellular traps, which stimulate innate immune pathways.
“Neutrophils migrate into the epidermis in response to keratinocyte-derived chemokines, forming characteristic microabscesses (Munro abscesses) and contributing to inflammation through proteases, reactive oxygen species, and extracellular traps, which stimulate innate immune pathways [26].”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [26]
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- Authors
- Lopez, D. V., & Kongsbak‐Wismann, M.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Kongsbak‐Wismann, Martin
- Venue
- Apmis
- Publisher
- Wiley
- Published
- 2022-04-06
- Volume
- 130
- Issue
- 6
- Pages
- 314-322
- ISSN
- 0903-4641 (ISSN-L)
- 1600-0463
- PMC
- PMC9324963
- OpenAlex
- W4220899108
- Cited by
- 66
- References
- 62
- Citations by year
- 2026: 10 · 2025: 28 · 2024: 19 · 2023: 8 · 2022: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Apmis (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- IL-22, skin homeostasis, skin diseases, keratinocyte proliferation, dermal fibroblasts, epithelial cells, innate immune response, antimicrobial proteins, neutrophil chemokines, wound healing, skin infections, psoriasis, atopic dermatitis, allergic contact dermatitis, T cells, innate lymphoid cells
- MeSH terms
- Interleukin-22, Homeostasis, Humans, Immunity, Innate, Interleukins, Lymphocytes, Psoriasis, Skin, Skin Diseases, Keratinocytes
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