The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cutting Edge: The Dendritic Cell Cytoskeleton Is Critical for the Formation of the Immunological Synapse
Open accessAbstract
The binding of a T cell to an APC results in T cell actin cytoskeletal rearrangement leading to the formation of an immunological synapse. The APC cytoskeleton has been thought to play a passive role in this process. In this study, we demonstrate that dendritic cells (DC), unlike other APC, actively polarize their actin cytoskeleton during interaction with T cells. DC cytoskeletal rearrangement was critical for both the clustering and the activation of resting T cells. This study provides compelling evidence that the APC cytoskeleton plays an active role in the immunological synapse and may explain the unique ability of DC to activate resting T cells.
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Cites
Bubb, M. R., Senderowicz, A. M., Sausville, E. A., Duncan, K. L., & Korn, E. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36545-6 · Cited by 811
Cited by
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Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L., & Germain, R. N. (2008) · Nature · doi:10.1038/nature07345 · Cited by 637
Dendritic Cells: Immune Regulators in Health and Disease
Lipscomb, M. F., & Masten, B. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00023.2001 · Cited by 465
Opposing Effects of PKCθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse
Sims, T. N., Soos, T. J., Xenias, H. S., Dubin-Thaler, B., Hofman, J. M., Waite, J. C., Cameron, T. O., Thomas, V. K., Varma, R., Wiggins, C. H., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.037 · Cited by 344
Borg, C., Jalil, A., Laderach, D., Maruyama, K., Wakasugi, H., Charrier, S., Ryffel, B., Cambi, A., Figdor, C., Vainchenker, W., et al. (2004) · Blood · doi:10.1182/blood-2004-01-0380 · Cited by 326
Metadata
- Authors
- Al-Alwan, M. M., Rowden, G., Lee, T. D. G., & West, K. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02-01
- Volume
- 166
- Issue
- 3
- Pages
- 1452-1456
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1761236405
- Cited by
- 220
- References
- 1
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Al-Alwan, M. M., Rowden, G., Lee, T. D. G., & West, K. A. (2001). Cutting Edge: The Dendritic Cell Cytoskeleton Is Critical for the Formation of the Immunological Synapse. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.3.1452
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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