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Cited by 326

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs

Borg, Christophe, Jalil, Abdelali, Laderach, Diego, Maruyama, Kouji, Wakasugi, Hiro, Charrier, Sabine, Ryffel, Bernhard, Cambi, Alessandra, Figdor, Carl, Vainchenker, William, Galy, Anne, Caignard, Anne, Zitvogel, Laurence·2004·Blood
DOI 10.1182/blood-2004-01-0380
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Abstract

Mature dendritic cells (mDCs) can trigger the effector functions of natural killer (NK) cells. Knock-out, small-interfering RNA or neutralizing antibodies targeting interleukin 12 (IL-12) subunits revealed a critical role for IL-12 in NK cell interferon γ (IFN-γ) secretion promoted by mDCs. However, NK cell activation by DCs also required direct cell-to-cell contacts. DC-mediated NK cell activation involved the formation of stimulatory synapses between DCs and NK cells. The formation of DC/NK cell conjugates depended on cytoskeleton remodeling and lipid raft mobilization in DCs. Moreover, the disruption of the DC cytoskeleton using pharmacologic agents or the loss-of-function mutation of the Wiskott-Aldrich syndrome protein abolished the DC-mediated NK cell activation. Synapse formation promoted the polarized secretion of preassembled stores of IL-12 by DCs toward the NK cell. The synaptic delivery of IL-12 by DCs was required for IFN-γ secretion by NK cells, as assessed using inhibitors of cytoskeleton rearrangements and transwell experiments. Therefore, the cross-talk between DCs and NK cells is dictated by functional synapses. (Blood. 2004;104:3267-3275)

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Metadata

Authors
Borg, C., Jalil, A., Laderach, D., Maruyama, K., Wakasugi, H., Charrier, S., Ryffel, B., Cambi, A., Figdor, C., Vainchenker, W., Galy, A., Caignard, A., & Zitvogel, L.
Venue
Blood
Publisher
American Society of Hematology
Published
2004-11-15
Volume
104
Issue
10
Pages
3267-3275
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2004-01-0380
OpenAlex
W2104685421
Cited by
326
References
48
FWCI
8.01
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. https://app.cochat.ai/papers/10.1182/blood-2004-01-0380
The paper
Borg, C., Jalil, A., Laderach, D., Maruyama, K., Wakasugi, H., Charrier, S., Ryffel, B., Cambi, A., Figdor, C., Vainchenker, W., Galy, A., Caignard, A., & Zitvogel, L. (2004). NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood. https://doi.org/10.1182/blood-2004-01-0380

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.