SAP-controlled T–B cell interactions underlie germinal centre formation

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,720 · see citing works

Antigen-specific interaction between T and B cells

Lanzavecchia, A. (1985) · Nature · doi:10.1038/314537a0 · Cited by 1,416 · see citing works

Intraclonal generation of antibody mutants in germinal centres

Jacob, J., Kelsoe, G. H., Rajewsky, K., & Weiss, U. K. (1991) · Nature · doi:10.1038/354389a0 · Cited by 1,092 · see citing works

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

Sayós, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., van Schaik, S., Notarangelo, L. D., Geha, R. S., Roncarolo, M., et al. (1998) · Nature · doi:10.1038/26683 · Cited by 940 · see citing works

Maturation of the immune response in germinal centers

Berek, C., Berger, A., & Apel, M. (1991) · Cell · doi:10.1016/0092-8674(91)90289-b · Cited by 914 · see citing works

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

Garside, P., Ingulli, E. G., Merica, R. R., Johnson, J. G., Noelle, R. J., & Jenkins, M. K. (1998) · Science · doi:10.1126/science.281.5373.96 · Cited by 774 · see citing works

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

Coffey, A. J., Brooksbank, R. A., Brandau, O., Oohashi, T., Howell, G. R., Bye, J. M., Cahn, A. P., Durham, J., Heath, P. D., Wray, P. W., et al. (1998) · Nature Genetics · doi:10.1038/2424 · Cited by 752 · see citing works

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

Liu, Y., Zhang, J., Lane, P. J. L., Chan, E. Y. ‐., & MacLennan, I. C. M. (1991) · European Journal of Immunology · doi:10.1002/eji.1830211209 · Cited by 736 · see citing works

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S., & Mackay, C. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.68 · Cited by 722 · see citing works

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

Stoll, S., Delon, J., Brotz, T. M., & Germain, R. N. (2002) · Science · doi:10.1126/science.1071065 · Cited by 718 · see citing works

The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation

Mitchison, N. A. (1971) · European Journal of Immunology · doi:10.1002/eji.1830010104 · Cited by 678 · see citing works

Follicular B helper T cells in antibody responses and autoimmunity

Vinuesa, C. G., Tangye, S. G., Moser, B., & Mackay, C. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1714 · Cited by 628 · see citing works

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

Okada, T., Miller, M. J., Parker, I., Krummel, M. F., Neighbors, M., Hartley, S. B., O’Garra, A., Cahalan, M. D., & Cyster, J. G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030150 · Cited by 586 · see citing works

X-LINKED RECESSIVE PROGRESSIVE COMBINED VARIABLE IMMUNODEFICIENCY (DUNCAN'S DISEASE)

Purtilo, D., Yang, J. S., Cassel, C., Harper, R., Stephenson, S., Landing, B. H., & Vawter, G. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92004-8 · Cited by 551 · see citing works

Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes

Miller, M. J., Safrina, O., Parker, I., & Cahalan, M. D. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041236 · Cited by 545 · see citing works

Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells

Qi, H., Egen, J. G., Huang, A. Y.-C., & Germain, R. N. (2006) · Science · doi:10.1126/science.1125703 · Cited by 521 · see citing works

In vivo imaging of germinal centres reveals a dynamic open structure

Schwickert, T. A., Lindquist, R. L., Shakhar, G., Livshits, G., Skokos, D., Kosco‐Vilbois, M. H., Dustin, M. L., & Nussenzweig, M. C. (2007) · Nature · doi:10.1038/nature05573 · Cited by 477 · see citing works

SAP is required for generating long-term humoral immunity

Crotty, S., Kersh, E. N., Cannons, J. L., Schwartzberg, P. L., & Ahmed, R. (2003) · Nature · doi:10.1038/nature01318 · Cited by 419 · see citing works

Germinal Centers without T Cells

Vinuesa, C. G., Cook, M., Ball, J., Drew, M., Sunners, Y., Cascalho, M., Wabl, M. R., Klaus, G. G. B., & MacLennan, I. C. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.485 · Cited by 299 · see citing works

The changing preference of T and B cells for partners as T‐dependent antibody responses develop

MacLennan, I. C. M., Gulbranson‐Judge, A., Toellner, K., Casamayor‐Palleja, M., Sze, D., Chan, E. Y., Luther, S. A., & Acha‐Orbea, H. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00958.x · Cited by 283 · see citing works

Role of Thymus-derived Lymphocytes in the Secondary Humoral Immune Response in Mice

RAFF, M. C. (1970) · Nature · doi:10.1038/2261257a0 · Cited by 282 · see citing works

Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.

Coico, R., Bhogal, B. S., & Thorbecke, G. J. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.5.2254 · Cited by 272 · see citing works

Regulation of Cellular and Humoral Immune Responses by the SLAM and SAP Families of Molecules

Ma, C. S., Nichols, K. E., & Tangye, S. G. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141651 · Cited by 263 · see citing works

Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A / DSHP / SAP

Czar, M. J., Kersh, E. N., Mijares, L. A., Lanier, G., Lewis, J., Yap, G. S., Chen, A. Y.-C., Sher, A., Duckett, C. S., Ahmed, R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131193098 · Cited by 260 · see citing works

Requirement of Rac1 and Rac2 Expression by Mature Dendritic Cells for T Cell Priming

Benvenuti, F., Hugues, S., Walmsley, M. J., Ruf, S., Fetler, L., Popoff, M. R., Tybulewicz, V. L. J., & Amigorena, S. (2004) · Science · doi:10.1126/science.1099159 · Cited by 239 · see citing works

SAP controls T cell responses to virus and terminal differentiation of TH2 cells

Wu, C., Nguyen, K. B., Pien, G. C., Wang, N., Gullo, C. A., Howie, D., Rodríguez‐Sosa, M., Edwards, M. J., Borrow, P., Satoskar, A. R., et al. (2001) · Nature Immunology · doi:10.1038/87713 · Cited by 233 · see citing works

SAP Regulates TH2 Differentiation and PKC-θ-Mediated Activation of NF-κB1

Cannons, J. L., Yu, L. J., Hill, B. J., Mijares, L. A., Dombroski, D. G., Nichols, K. E., Antonellis, A., Koretzky, G. A., Gardner, K. L., & Schwartzberg, P. L. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.012 · Cited by 232 · see citing works

Cutting Edge: The Dendritic Cell Cytoskeleton Is Critical for the Formation of the Immunological Synapse

Al-Alwan, M. M., Rowden, G., Lee, T. D. G., & West, K. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1452 · Cited by 220 · see citing works

Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation

Celli, S., Lemaı̂tre, F., & Bousso, P. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.018 · Cited by 194 · see citing works

Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells

Ma, C. S., Hare, N. J., Nichols, K. E., Dupré, L., Andolfi, G., Roncarolo, M., Adelstein, S., Hodgkin, P. D., & Tangye, S. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23139 · Cited by 171 · see citing works

SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation

Cannons, J. L., Yu, L. J., Jankovic, D. L., Crotty, S., Horai, R., Kirby, M., Anderson, S. M., Cheever, A. W., Sher, A., & Schwartzberg, P. L. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052097 · Cited by 155 · see citing works

Genetic Evidence Linking SAP, the X-Linked Lymphoproliferative Gene Product, to Src-Related Kinase FynT in TH2 Cytokine Regulation

Davidson, D., Shi, X., Zhang, S., Wang, H., Nemer, M. J., Ono, N., Ohno, S., Yanagi, Y., & Veillette, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.005 · Cited by 149 · see citing works

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6

Dent, A. L., Hu‐Li, J., Paul, W. E., & Staudt, L. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13823 · Cited by 142 · see citing works

CXCR5+ T cells: follicular homing takes center stage in T-helper-cell responses

Moser, B., Schaerli, P., & Loetscher, P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02218-4 · Cited by 116 · see citing works

SH2D1A Regulates T-dependent Humoral Autoimmunity

Hron, J. D., Caplan, L., Gerth, A., Schwartzberg, P. L., & Peng, S. L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040526 · Cited by 114 · see citing works

SAP Regulation of Follicular Helper CD4 T Cell Development and Humoral Immunity Is Independent of SLAM and Fyn Kinase

McCausland, M. M., Yusuf, I., Tran, H., Ono, N., Yanagi, Y., & Crotty, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.817 · Cited by 103 · see citing works

Competition for antigen determines the stability of T cell–dendritic cell interactions during clonal expansion

Garcia, Z., Pradelli, E., Celli, S., Beuneu, H., Simon, A., & Bousso, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610019104 · Cited by 90 · see citing works

Antigen presentation by hapten-specific B lymphocytes. II. Specificity and properties of antigen-presenting B lymphocytes, and function of immunoglobulin receptors.

Abbas, A. K., Haber, S. I., & Rock, K. L. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.3.1661 · Cited by 84 · see citing works

Illuminating the Landscape of In Vivo Immunity

Huang, A. Y.-C., Qi, H., & Germain, R. N. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.001 · Cited by 75 · see citing works

Defective B cell responses in the absence of SH2D1A

Morra, M., Barrington, R. A., Abadía‐Molina, A. C., Okamoto, S., Julien, A., Gullo, C. A., Kalsy, A., Edwards, M. J., Chen, G., Spolski, R. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408681102 · Cited by 72 · see citing works

Immunoglobulin class and subclass deficiencies prior to Epstein‐Barr virus infection in males with X‐linked lymphoproliferative disease

Grierson, H. L., Skare, J. C., Hawk, J. L. M., Pauza, M. E., & Purtilo, D. T. (1991) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320400309 · Cited by 71 · see citing works

Sites of B-cell activation in vivo

Kelsoe, G. H., & Zheng, B. Q. (1993) · Current Opinion in Immunology · doi:10.1016/0952-7915(93)90062-w · Cited by 68 · see citing works

Relationship of germinal centers in lymphoid tissue to immunologic memory. V. The effect of prednisolone administered after the peak of the primary response.

Durkin, H. G., & Thorbecke, G. J. (1971) · PubMed · Cited by 62 · see citing works

Hypogammaglobulinemia and exacerbated CD8 T-cell–mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease

Crotty, S., McCausland, M. M., Aubert, R. D., Wherry, E. J., & Ahmed, R. (2006) · Blood · doi:10.1182/blood-2006-04-018929 · Cited by 48 · see citing works

Absence of interleukin-4 enhances germinal center reaction in secondary immune response

Andoh, A., Masuda, A., Yamakawa, M., Kumazawa, Y., & Kasajima, T. (2000) · Immunology Letters · doi:10.1016/s0165-2478(00)00202-9 · Cited by 17 · see citing works

Follicular Helper CD4 T Cells (T _FH )

Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738 · see citing works

Germinal Centers

Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878 · see citing works

T follicular helper cell differentiation, function, and roles in disease

Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847 · see citing works

Foxp3+ follicular regulatory T cells control the germinal center response

Linterman, M. A., Pierson, W., Lee, S. K., Kallies, A., Kawamoto, S., Rayner, T. F., Srivastava, M., Divekar, D. P., Beaton, L., Hogan, J. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2425 · Cited by 1,292 · see citing works

Follicular helper T cells

Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141 · see citing works

Dynamics of B cells in germinal centres

De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084 · see citing works

T cells in health and disease

Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,060 · see citing works

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

Choi, Y. S., Kageyama, R., Eto, D. S., Escobar, T. C., Johnston, R. J., Monticelli, L. A., Lao, C., & Crotty, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.023 · Cited by 959 · see citing works

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

Turner, J. S., O’Halloran, J. A., Kalaidina, E., Kim, W., Schmitz, A. J., Zhou, J. Q., Lei, T., Thapa, M., Chen, R. E., Case, J. B., et al. (2021) · Nature · doi:10.1038/s41586-021-03738-2 · Cited by 831 · see citing works

The who, how and where of antigen presentation to B cells

Batista, F. D., & Harwood, N. E. (2008) · Nature reviews. Immunology · doi:10.1038/nri2454 · Cited by 775 · see citing works

Memory B cells

Kurosaki, T., Kometani, K., & Ise, W. (2015) · Nature reviews. Immunology · doi:10.1038/nri3802 · Cited by 698 · see citing works

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

He, J., Tsai, L. M., Leong, Y. A., Hu, X., Ma, C. S., Chevalier, N., Sun, X., Vandenberg, K. L., Rockman, S., Ding, Y. P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.007 · Cited by 642 · see citing works

From Vaccines to Memory and Back

Sallusto, F., Lanzavecchia, A., Araki, K., & Ahmed, R. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.008 · Cited by 631 · see citing works

Follicular Helper T Cells: Lineage and Location

Fazilleau, N., Mark, L., McHeyzer‐Williams, L. J., & McHeyzer‐Williams, M. G. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.003 · Cited by 593 · see citing works

A brief history of T cell help to B cells

Crotty, S. (2015) · Nature reviews. Immunology · doi:10.1038/nri3803 · Cited by 552 · see citing works

The origins, function, and regulation of T follicular helper cells

Ma, C. S., Deenick, E. K., Batten, M., & Tangye, S. G. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120994 · Cited by 554 · see citing works

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

Eto, D., Lao, C., Ditoro, D., Barnett, B., Escobar, T. C., Kageyama, R., Yusuf, I., & Crotty, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017739 · Cited by 569 · see citing works

The good, the bad and the ugly — TFH cells in human health and disease

Tangye, S. G., Ma, C. S., Brink, R. A., & Deenick, E. K. (2013) · Nature reviews. Immunology · doi:10.1038/nri3447 · Cited by 527 · see citing works

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

Fagarasan, S., Kawamoto, S., Kanagawa, O., & Suzuki, K. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101314 · Cited by 501 · see citing works

SLAM Family Receptors and SAP Adaptors in Immunity

Cannons, J. L., Tangye, S. G., & Schwartzberg, P. L. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101302 · Cited by 495 · see citing works

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

Kerfoot, S. M., Yaari, G., Patel, J. R., Johnson, K. L., Gonzalez, D. G., Kleinstein, S. H., & Haberman, A. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.024 · Cited by 494 · see citing works

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

Baumjohann, D., Preite, S., Reboldi, A., Ronchi, F., Ansel, K. M., Lanzavecchia, A., & Sallusto, F. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.020 · Cited by 484 · see citing works

Dendritic Cell Regulation of T Helper Cells

Yin, X., Chen, S., & Eisenbarth, S. C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-025146 · Cited by 447 · see citing works

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

Odumade, O. A., Hogquist, K. A., & Balfour, H. H. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00044-10 · Cited by 457 · see citing works

PD-1 Controls Follicular T Helper Cell Positioning and Function

Shi, J., Hou, S., Fang, Q., Liu, X., Liu, X., & Qi, H. (2018) · Immunity · doi:10.1016/j.immuni.2018.06.012 · Cited by 455 · see citing works

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

Fazilleau, N., McHeyzer‐Williams, L. J., Rosen, H., & McHeyzer‐Williams, M. G. (2009) · Nature Immunology · doi:10.1038/ni.1704 · Cited by 452 · see citing works

Molecular programming of B cell memory

McHeyzer-Williams, M., Okitsu, S., Wang, N., & McHeyzer-Williams, L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3128 · Cited by 449 · see citing works

Functional Anatomy of T Cell Activation and Synapse Formation

Fooksman, D., Vardhana, S. A., Vasiliver-Shamis, G., Liese, J., Blair, D. A., Waite, J. C., Sacristán, C., Victora, G. D., Zanin‐Zhorov, A., & Dustin, M. L. (2009) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101308 · Cited by 449 · see citing works

Control systems and decision making for antibody production

Goodnow, C. C., Vinuesa, C. G., Randall, K. L., Mackay, F., & Brink, R. A. (2010) · Nature Immunology · doi:10.1038/ni.1900 · Cited by 443 · see citing works

Pathophysiology of T follicular helper cells in humans and mice

Ueno, H., Banchereau, J., & Vinuesa, C. G. (2015) · Nature Immunology · doi:10.1038/ni.3054 · Cited by 441 · see citing works

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

Schwickert, T. A., Victora, G. D., Fooksman, D., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., Dustin, M. L., & Nussenzweig, M. C. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102477 · Cited by 427 · see citing works

Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses

Hilligan, K. L., & Ronchese, F. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0465-0 · Cited by 433 · see citing works

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

Liu, D., Xu, H., Shih, C., Wan, Z., Ma, X., Ma, W., Luo, D., & Qi, H. (2014) · Nature · doi:10.1038/nature13803 · Cited by 423 · see citing works

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

Yusuf, I., Kageyama, R., Monticelli, L. A., Johnston, R. J., Ditoro, D. F., Hansen, K., Barnett, B. E., & Crotty, S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903505 · Cited by 421 · see citing works

Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

Kitano, M., Moriyama, S., Ando, Y., Hikida, M., Mori, Y., Kurosaki, T., & Okada, T. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.025 · Cited by 412 · see citing works

Phenotype and functions of memory Tfh cells in human blood

Schmitt, N., Bentebibel, S.-E., & Ueno, H. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.06.002 · Cited by 408 · see citing works

Early Events in B Cell Activation

Harwood, N. E., & Batista, F. D. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101216 · Cited by 404 · see citing works

Dynamic signaling by T follicular helper cells during germinal center B cell selection

Shulman, Z., Gitlin, A. D., Weinstein, J. S., Lainez, B., Esplugues, E., Flavell, R. A., Craft, J. E., & Nussenzweig, M. C. (2014) · Science · doi:10.1126/science.1257861 · Cited by 387 · see citing works

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

Xu, H., Li, X., Liu, D., Li, J., Zhang, X., Chen, X., Hou, S., Peng, L., Xu, C., Liu, W., et al. (2013) · Nature · doi:10.1038/nature12058 · Cited by 390 · see citing works

Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84

Cannons, J. L., Qi, H., Lu, K. T., Dutta, M., Gómez‐Rodríguez, J., Cheng, J., Wakeland, E. K., Germain, R. N., & Schwartzberg, P. L. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.010 · Cited by 384 · see citing works

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

Ise, W., Kohyama, M., Schraml, B. U., Zhang, T., Schwer, B., Basu, U., Alt, F. W., Tang, J., Oltz, E. M., Murphy, T. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2037 · Cited by 377 · see citing works

Follicular helper T cells in immunity and systemic autoimmunity

Craft, J. E. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.58 · Cited by 375 · see citing works

A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System

Germain, R. N., Robey, E. A., & Cahalan, M. D. (2012) · Science · doi:10.1126/science.1221063 · Cited by 370 · see citing works

T Follicular Helper Cell Dynamics in Germinal Centers

Shulman, Z., Gitlin, A. D., Targ, S., Janković, M., Pasqual, G., Nussenzweig, M. C., & Victora, G. D. (2013) · Science · doi:10.1126/science.1241680 · Cited by 363 · see citing works

Regulation of the Germinal Center Response

Stebegg, M., Kumar, S. D., Silva-Cayetano, A., Fonseca, V. R., Linterman, M. A., & Graca, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02469 · Cited by 349 · see citing works

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)

Schmid, J. P., Canioni, D., Moshous, D., Touzot, F., Mahlaoui, N., Hauck, F. H., Kanegane, H., López‐Granados, E., Mejstříková, E., Pellier, I., et al. (2010) · Blood · doi:10.1182/blood-2010-07-298372 · Cited by 362 · see citing works

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

Kroenke, M. A., Eto, D. S., Locci, M., Cho, M., Davidson, T. M., Haddad, E. K., & Crotty, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103246 · Cited by 355 · see citing works

Heterogeneity of CD4⁺ memory T cells: Functional modules for tailored immunity

Sallusto, F., & Lanzavecchia, A. (2009) · European Journal of Immunology · doi:10.1002/eji.200939722 · Cited by 348 · see citing works

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

Deenick, E. K., Chan, A., Ma, C. S., Gatto, D., Schwartzberg, P. L., Brink, R. A., & Tangye, S. G. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.015 · Cited by 347 · see citing works

Mechanisms that determine plasma cell lifespan and the duration of humoral immunity

Amanna, I. J., & Slifka, M. K. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00912.x · Cited by 343 · see citing works

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

Liu, X., Chen, X., Zhong, B., Wang, A., Wang, X., Chu, F., Nurieva, R., Yan, X. S., Chen, P., van der Flier, L. G., et al. (2014) · Nature · doi:10.1038/nature12910 · Cited by 343 · see citing works

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL‐12

Ma, C. S., Suryani, S., Avery, D. T., Chan, A., Nanan, R. K. H., Santner‐Nanan, B., Deenick, E. K., & Tangye, S. G. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.64 · Cited by 345 · see citing works

Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection

Hale, J. S., Youngblood, B., Latner, D. R., Mohammed, A. U. R., Ye, L., Akondy, R. S., Wu, T., Iyer, S. S., & Ahmed, R. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.020 · Cited by 330 · see citing works

T follicular regulatory cells

Sage, P. T., & Sharpe, A. H. (2016) · Immunological Reviews · doi:10.1111/imr.12411 · Cited by 327 · see citing works

CD4 T follicular helper cell dynamics during SIV infection

Petrovas, C., Yamamoto, T., Gerner, M. Y., Boswell, K. L., Wloka, K., Smith, E. C., Ambrozak, D. R., Utay, N. S., Timmer, K. J., Sun, X., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63039 · Cited by 317 · see citing works

The differential expression of IL-4 and IL-13 and its impact on type-2 immunity

Bao, K., & Reinhardt, R. L. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.008 · Cited by 316 · see citing works

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

Lee, S. K., Rigby, R. J., Zotos, D., Tsai, L. M., Kawamoto, S., Marshall, J. L., Ramiscal, R. R., Chan, T. D., Gatto, D., Brink, R. A., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102065 · Cited by 312 · see citing works

T cells and follicular dendritic cells in germinal center B‐cell formation and selection

Vinuesa, C. G., Linterman, M. A., Goodnow, C. C., & Randall, K. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00937.x · Cited by 298 · see citing works

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

Chang, P.-P., Barral, P., Fitch, J., Pratama, A., Ma, C. S., Kallies, A., Hogan, J. J., Cerundolo, V., Tangye, S. G., Bittman, R., et al. (2011) · Nature Immunology · doi:10.1038/ni.2166 · Cited by 301 · see citing works

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

Steinfelder, S., Andersen, J. F., Cannons, J. L., Feng, C. G., Joshi, M. B., Dwyer, D. M., Caspar, P., Schwartzberg, P. L., Sher, A., & Jankovic, D. L. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082462 · Cited by 294 · see citing works

Memory B and memory plasma cells

Yoshida, T., Mei, H. E., Dörner, T., Hiepe, F., Radbruch, A., Fillatreau, S., & Hoyer, B. F. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00938.x · Cited by 288 · see citing works

T follicular helper cells in space-time

Qi, H. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.94 · Cited by 272 · see citing works

Contributions of humoral and cellular immunity to vaccine-induced protection in humans

Amanna, I. J., & Slifka, M. K. (2011) · Virology · doi:10.1016/j.virol.2010.12.016 · Cited by 263 · see citing works

Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells

Lu, K. T., Kanno, Y., Cannons, J. L., Handon, R., Bible, P. W., Elkahloun, A. G., Anderson, S. M., Wei, L., Sun, H., O’Shea, J. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.07.015 · Cited by 259 · see citing works

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

Randall, K. L., Lambe, T., Johnson, A. L., Treanor, B., Kucharska, E. M., Domaschenz, H., Whittle, B., Tze, L. E., Enders, A., Crockford, T. L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1820 · Cited by 251 · see citing works

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

Lee, S. K., Silva, D. G., Martin, J. L., Pratama, A., Hu, X., Chang, P.-P., Walters, G. D., & Vinuesa, C. G. (2012) · Immunity · doi:10.1016/j.immuni.2012.10.010 · Cited by 248 · see citing works

Metabolic Regulation of the Immune Humoral Response

Boothby, M. R., & Rickert, R. C. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.009 · Cited by 245 · see citing works

Type I interferon induces CXCL13 to support ectopic germinal center formation

Denton, A. E., Innocentin, S., Carr, E. J., Bradford, B. M., Lafouresse, F., Mabbott, N. A., Mörbe, U., Ludewig, B., Groom, J. R., Good‐Jacobson, K. L., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181216 · Cited by 244 · see citing works

Analysing immune cell migration

Beltman, J. B., Marée, A. F. M., & de Boer, R. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2638 · Cited by 242 · see citing works

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

Goenka, R., Barnett, L. G., Silver, J. S., O’Neill, P. J., Hunter, C. A., Cancro, M. P., & Laufer, T. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100853 · Cited by 229 · see citing works

Systemic Lupus Erythematosus Pathogenesis: Interferon and Beyond

Caielli, S., Wan, Z., & Pascual, V. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-042422 · Cited by 221 · see citing works

Plasticity and Heterogeneity in the Generation of Memory B Cells and Long-Lived Plasma Cells: The Influence of Germinal Center Interactions and Dynamics

Good‐Jacobson, K. L., & Shlomchik, M. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001155 · Cited by 221 · see citing works

SLAM receptors and SAP influence lymphocyte interactions, development and function

Schwartzberg, P. L., Mueller, K. L., Qi, H., & Cannons, J. L. (2008) · Nature reviews. Immunology · doi:10.1038/nri2456 · Cited by 220 · see citing works

Primary antibody deficiencies

Durandy, A., Kracker, S., & Fischer, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3466 · Cited by 220 · see citing works

New insights into the differentiation and function of T follicular helper cells

King, C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2644 · Cited by 215 · see citing works

Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

Liarski, V. M., Kaverina, N. V., Chang, A., Brandt, D. R., Yanez, D., Talasnik, L. A., Carlesso, G., Herbst, R., Utset, T. O., Labno, C. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008146 · Cited by 210 · see citing works

How T Cells Earn the Follicular Rite of Passage

Vinuesa, C. G., & Cyster, J. G. (2011) · Immunity · doi:10.1016/j.immuni.2011.11.001 · Cited by 211 · see citing works

T follicular helper cells in germinal center B cell selection and lymphomagenesis

Mintz, M. A., & Cyster, J. G. (2020) · Immunological Reviews · doi:10.1111/imr.12860 · Cited by 206 · see citing works

B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1

Karnowski, A., Chevrier, S., Belz, G. T., Mount, A. M., Emslie, D., D’Costa, K., Tarlinton, D. M., Kallies, A., & Corcoran, L. M. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111504 · Cited by 204 · see citing works

T follicular helper cell heterogeneity: Time, space, and function

Song, W., & Craft, J. E. (2019) · Immunological Reviews · doi:10.1111/imr.12740 · Cited by 203 · see citing works

Decreased microRNA‐142‐3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus

Ding, S., Liang, Y., Zhao, M., Liang, G., Long, H., Zhao, S., Wang, Y., Yin, H., Zhang, P., Zhang, Q., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34505 · Cited by 197 · see citing works

Follicular helper T cells as cognate regulators of B cell immunity

McHeyzer‐Williams, L. J., Pelletier, N., Mark, L., Fazilleau, N., & McHeyzer‐Williams, M. G. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.010 · Cited by 191 · see citing works

Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

Herati, R. S., Reuter, M. A., Dolfi, D. V., Mansfield, K. D., Aung, H., Badwan, O. Z., Kurupati, R. K., Kannan, S., Ertl, H., Schmader, K. E., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302503 · Cited by 177 · see citing works

T‐cell subsets in the germinal center

Ramiscal, R. R., & Vinuesa, C. G. (2013) · Immunological Reviews · doi:10.1111/imr.12031 · Cited by 181 · see citing works

Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue

Qi, H., Kastenmüller, W., & Germain, R. N. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013254 · Cited by 180 · see citing works

Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells

Wang, Y., Shi, J., Yan, J., Xiao, Z., Hou, X., Lu, P., Hou, S., Mao, T., Liu, W., Ma, Y., et al. (2017) · Nature Immunology · doi:10.1038/ni.3788 · Cited by 175 · see citing works

The link between circulating follicular helper T cells and autoimmunity

Walker, L. S. K. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00693-5 · Cited by 178 · see citing works

TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection

Wu, T., Shin, H. M., Moseman, E. A., Ji, Y., Huang, B., Harly, C., Sen, J. M., Berg, L. J., Gattinoni, L., McGavern, D. B., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.049 · Cited by 167 · see citing works

Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency

Snow, A. L., Marsh, R. A., Krummey, S. M., Roehrs, P., Young, L. R., Zhang, K., van Hoff, J., Dhar, D., Nichols, K. E., Filipovich, A. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39518 · Cited by 165 · see citing works

Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease

Hirahara, K., Poholek, A. C., Vahedi, G., Laurence, A. D. J., Kanno, Y., Milner, J. D., & O’Shea, J. J. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.03.015 · Cited by 162 · see citing works

The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development

Kageyama, R., Cannons, J. L., Zhao, F. R., Yusuf, I., Lao, C., Locci, M., Schwartzberg, P. L., & Crotty, S. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.016 · Cited by 162 · see citing works

The elusive identity of T follicular helper cells

Yu, D., & Vinuesa, C. G. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.07.001 · Cited by 162 · see citing works

Memory T Follicular Helper CD4 T Cells

Hale, J. S., & Ahmed, R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00016 · Cited by 155 · see citing works

Regulators of Tfh Cell Differentiation

Jogdand, G. M., Mohanty, S., & Devadas, S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00520 · Cited by 155 · see citing works

Plasma cells negatively regulate the follicular helper T cell program

Pelletier, N., McHeyzer‐Williams, L. J., Wong, K. A., Urich, E., Fazilleau, N., & McHeyzer‐Williams, M. G. (2010) · Nature Immunology · doi:10.1038/ni.1954 · Cited by 152 · see citing works

Primary Immunodeficiencies Associated with EBV Disease

Cohen, J. I. (2015) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-22822-8_10 · Cited by 151 · see citing works

POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function

Lee, S., & Maeda, T. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01116.x · Cited by 150 · see citing works

T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship

Petersone, L., Edner, N. M., Ovcinnikovs, V., Heuts, F. W. H., Ross, E. M., Ntavli, E., Wang, C. J., & Walker, L. S. K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01941 · Cited by 147 · see citing works

Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity

Zappasodi, R., Budhu, S., Hellmann, M. D., Postow, M. A., Senbabaoglu, Y., Manne, S., Gasmi, B., Liu, C., Zhong, H., Li, Y., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.05.009 · Cited by 142 · see citing works

Asymmetric Segregation of Polarized Antigen on B Cell Division Shapes Presentation Capacity

Thaunat, O., Granja, A. G., Barral, P., Filby, A. J., Montaner, B., Collinson, L., Martínez, N., Harwood, N. E., Bruckbauer, A., & Batista, F. D. (2012) · Science · doi:10.1126/science.1214100 · Cited by 143 · see citing works

Helpful T cells are sticky

Deenick, E. K., & Tangye, S. G. (2008) · Nature · doi:10.1038/455745a · Cited by 2 · see citing works

From SAP‐less T cells to helpless B cells and back: dynamic T–B cell interactions underlie germinal center development and function

Qi, H. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01119.x · Cited by 37 · see citing works

SAP Regulation of Follicular Helper CD4 T Cell Development and Humoral Immunity Is Independent of SLAM and

Kinase, F., & Crotty, S. (2014)

SAP expression in T cells, not in B cells, is required for humoral immunity

Veillette, A., Zhang, S., Shi, X., Dong, Z., Davidson, D., & Zhong, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710698105 · Cited by 75 · see citing works

Critical Role of SAP in Progression and Reactivation but Not Maintenance of T Cell-Dependent Humoral Immunity

Zhong, M., & Veillette, A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01591-12 · Cited by 9 · see citing works