The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Surfactant Protein A Enhances Alveolar Macrophage Phagocytosis of Apoptotic Neutrophils
Abstract
Surfactant protein A (SP-A) is an innate immune molecule that binds foreign organisms that invade the lungs and targets them for phagocytic clearance by the resident pulmonary phagocyte, the alveolar macrophage (AM). We hypothesized that SP-A binds to and enhances macrophage uptake of other nonself particles, specifically apoptotic polymorphonuclear neutrophils (PMNs). PMNs are recruited into the lungs during inflammation, but as inflammation is resolved, PMNs undergo apoptosis and are phagocytosed by AMs. We determined that SP-A increases AM phagocytosis of apoptotic PMNs 280 ± 62% above the no protein control value. The increase is dose dependent, and heat-treated SP-A still enhanced uptake, whereas deglycosylated SP-A had significantly diminished ability to enhance phagocytosis. Surfactant protein D also increased phagocytosis of apoptotic PMNs by ∼125%. However, other proteins that are structurally homologous to SP-A, mannose-binding lectin and complement protein 1q, did not. SP-A enhances phagocytosis via an opsonization-dependent mechanism and binds apoptotic PMNs ∼4-fold more than viable PMNs. Also, binding of SP-A to apoptotic PMNs does not appear to involve SP-A’s lectin domain. These data suggest that the pulmonary collectins SP-A and SP-D facilitate the resolution of inflammation by accelerating apoptotic PMN clearance.
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Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824
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Cited by
Immunoregulatory functions of surfactant proteins
Wright, J. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1528 · Cited by 964
Self-citationCollectins and Ficolins: Humoral Lectins of the Innate Immune Defense
Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762
Surfactant proteins SP-A and SP-D: structure, function and receptors
Kishore, U., Greenhough, T. J., Waters, P., Shrive, A. K., Ghai, R., Kamran, M. F., Bernal, A. L., Reid, K. B. M., Madan, T., & Chakraborty, T. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.08.004 · Cited by 523
Vandivier, R. W., Fadok, V. A., Hoffmann, P. R., Bratton, D. L., Penvari, C., Brown, K. K., Brain, J. D., Accurso, F. J., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13572 · Cited by 373
Development and Functions of Alveolar Macrophages
Woo, Y. D., Jeong, D., & Chung, D. H. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0058 · Cited by 110
Metadata
- Authors
- Schagat, T. L., Wofford, J. A., & Wright, J. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02
- Volume
- 166
- Issue
- 4
- Pages
- 2727-2733
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1617119238
- Cited by
- 209
- References
- 3
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schagat, T. L., Wofford, J. A., & Wright, J. R. (2001). Surfactant Protein A Enhances Alveolar Macrophage Phagocytosis of Apoptotic Neutrophils. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.4.2727
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