The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions
Abstract
Inducible costimulator (ICOS) is a new member of the CD28/CTLA-4 family that is expressed on activated and germinal center (GC) T cells. Recently, we reported that ICOS-deficient mice exhibited profound defects in T cell activation and effector function. Ab responses in a T-dependent primary reaction and in a murine asthma model were also diminished. In the current study, we investigate the mechanism by which ICOS regulates humoral immunity and examine B cell GC reactions in the absence of ICOS. We found that ICOS−/− mice, when immunized with SRBC, had smaller GCs. Furthermore, IgG1 class switching in the GCs was impaired. Remarkably, GC formation in response to a secondary recall challenge was completely absent in ICOS knockout mice. These data establish a critical role of ICOS in regulation of humoral immunity.
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Citations
Cites
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999) · Nature · doi:10.1038/16717 · Cited by 1,482
Cited by
Vinuesa, C. G., Cook, M. C., Angelucci, C., Athanasopoulos, V., Rui, L., Hill, K. M., Yu, D., Domaschenz, H., Whittle, B., Lambe, T., et al. (2005) · Nature · doi:10.1038/nature03555 · Cited by 862
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
Grimbacher, B., Hutloff, A., Schlesier, M., Glocker, E., Warnatz, K., Dräger, R., Eibel, H., Fischer, B., Schäffer, A. A., Mages, H. W., et al. (2003) · Nature Immunology · doi:10.1038/ni902 · Cited by 733
Bauquet, A. T., Jin, H., Paterson, A. M., Mitsdoerffer, M., Ho, I.-C., Sharpe, A. H., & Kuchroo, V. K. (2009) · Nature Immunology · doi:10.1038/ni.1690 · Cited by 713
T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses
King, C., Tangye, S. G., & Mackay, C. R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090344 · Cited by 632
Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells
Wollenberg, I., Agua-Doce, A., Hernández, A., Almeida, C., Oliveira, V. G., Faro, J., & Graca, L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101328 · Cited by 599
Metadata
- Authors
- Dong, C., Temann, U.-A., & Flavell, R. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-03
- Volume
- 166
- Issue
- 6
- Pages
- 3659-3662
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1926858130
- Cited by
- 209
- References
- 1
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dong, C., Temann, U.-A., & Flavell, R. A. (2001). Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.6.3659
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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