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Cited by 713T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

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Bauquet, Aurelie T, Jin, Hulin, Paterson, Alison M, Mitsdoerffer, Meike, Ho, I-Cheng, Sharpe, Arlene H, Kuchroo, Vijay K·2009·Nature Immunology
DOI 10.1038/ni.1690PMC PMC2742982
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Abstract

The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells) and of follicular helper T cells (T(FH) cells). Here we show that ICOS-deficient mice had no defect in T(H)-17 differentiation but had fewer T(H)-17 cells after IL-23 stimulation and fewer T(FH) cells. We also show that T(FH) cells produced IL-17 and that T(FH) cells in ICOS-deficient mice were defective in IL-17 production. Both T(H)-17 and T(FH) cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells.

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  • Hippocampal TFH-17-like cells associated with learned-helplessness were activated, as they express ICOS, whereas TFH-17-like cells in resilient mice do not express ICOS.

    “The hippocampal TFH-17-like cells associated with learned-helplessness were activated, as they express ICOS (Bauquet et al., 2009), whereas TFH-17-like cells in resilient mice do not express ICOS (Fig 5I-J).”

    From Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression (2018) · cites this paper as Bauquet et al., 2009

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Authors
Bauquet, A. T., Jin, H., Paterson, A. M., Mitsdoerffer, M., Ho, I.-C., Sharpe, A. H., & Kuchroo, V. K.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Kuchroo, Vijay K
ORCID
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2008-12-21
Volume
10
Issue
2
Pages
167-175
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
DOI
10.1038/ni.1690
PMC
PMC2742982
OpenAlex
W2000049562
Cited by
713
References
7
Citations by year
2026: 11 · 2025: 20 · 2024: 18 · 2023: 21 · 2022: 30 · 2021: 35 · 2020: 34 · 2019: 47 · 2018: 37 · 2017: 30 · 2016: 53 · 2015: 53 · 2014: 57 · 2013: 64 · 2012: 62
FWCI
18.50
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Public Health Service (2P01A139671-07)
  • National Institute of Allergy and Infectious Diseases (1R01 AI44880-03, R37AI038310, R01AI044880, P01AI056299, P01AI039671)
  • National Institute of Neurological Disorders and Stroke (2R37NS30843-11, R01NS046414, P01NS38037-04, P01NS038037, R37NS030843, R01NS035685, 2R01NS35685-06, R01NS045937)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
ICOS, c-Maf, IL-21, T follicular helper cells, IL-17, costimulation, IL-23, transcriptional regulation, T cell differentiation
MeSH terms
Interleukin-21, Animals, Antigens, Differentiation, T-Lymphocyte, Cell Differentiation, Encephalomyelitis, Autoimmune, Experimental, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Gene Expression Regulation, T-Lymphocytes, Helper-Inducer, Interleukins, Mice, Transgenic, T-Lymphocyte Subsets, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17, Oligonucleotide Array Sequence Analysis, Cell Proliferation, Proto-Oncogene Proteins c-maf, Mice, Inducible T-Cell Co-Stimulator Protein

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