The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
IFN-γ Overproduction and High Level Apoptosis Are Associated with High but Not Low Virulence Toxoplasma gondii Infection
Open accessAbstract
Toxoplasma gondii is an opportunistic intracellular parasite which induces a highly strong type 1 cytokine response. The present study focuses on defining the factors influencing the outcome of infection with tachyzoites of the type I, highly lethal RH strain, relative to the type II, low virulence strain ME49. Infection with the RH strain led to widespread parasite dissemination and rapid death of mice; in contrast, mice survived low virulence strain ME49 infection, and tachyzoite dissemination was much less extensive. Furthermore, massive apoptosis and disintegration of the splenic architecture was characteristic of RH, but not ME49, infection. In addition, hyperinduction of IFN-γ and lack of NO production were found during RH, in contrast to ME49 infection. These data demonstrate that Toxoplasma strain characteristics exert a profound effect on the host immune response and that the latter itself is a crucial determinant in parasite virulence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Cited by
Pyroptotic cell death defends against intracellular pathogens
Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021
Acute Toxoplasmosis Leads to Lethal Overproduction of Th1 Cytokines
Mordue, D. G., Monroy, F., La Regina, M., Dinarello, C. A., & Sibley, L. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4574 · Cited by 396
Saeij, J. P. J., Boyle, J. P., & Boothroyd, J. C. (2005) · Trends in Parasitology · doi:10.1016/j.pt.2005.08.001 · Cited by 351
Toxoplasma Effectors Targeting Host Signaling and Transcription
Hakimi, M.-A., Olias, P., & Sibley, L. D. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00005-17 · Cited by 339
Alternatively activated macrophages during parasite infections
Noël, W. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.01.004 · Cited by 301
Metadata
- Authors
- Gavrilescu, L. C., & Denkers, E. Y.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-07
- Volume
- 167
- Issue
- 2
- Pages
- 902-909
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2138814634
- Cited by
- 179
- References
- 1
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: IFN-γ Overproduction and High Level Apoptosis Are Associated with High but Not Low Virulence Toxoplasma gondii Infection. https://app.cochat.ai/papers/10.4049/jimmunol.167.2.902
- The paper
- Gavrilescu, L. C., & Denkers, E. Y. (2001). IFN-γ Overproduction and High Level Apoptosis Are Associated with High but Not Low Virulence Toxoplasma gondii Infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.167.2.902
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
