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Cited by 716

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

Open access
Piccirillo, Ciriaco A, Shevach, Ethan M·2001·The Journal of Immunology
DOI 10.4049/jimmunol.167.3.1137
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Abstract

CD4+CD25+ regulatory T cells inhibit organ-specific autoimmune diseases induced by CD4+CD25− T cells and are potent suppressors of CD4+CD25− T cell activation in vitro. We demonstrate that CD4+CD25+ T cells also suppress both proliferation and IFN-γ production by CD8+ T cells induced either by polyclonal or Ag-specific stimuli. CD4+CD25+ T cells inhibit the activation of CD8+ responders by inhibiting both IL-2 production and up-regulation of IL-2Rα-chain (CD25) expression. Suppression is mediated via a T-T interaction as activated CD4+CD25+ T cells suppress the responses of TCR-transgenic CD8+ T cells stimulated with soluble peptide-MHC class I tetramers in the complete absence of APC. These results broaden the immunoregulatory role played by CD4+CD25+ T cells in the prevention of autoimmune diseases, but also raise the possibility that they may hinder the induction of effector CD8+ T cells to tumor or foreign Ags.

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Crossref · 10.4049/jimmunol.167.3.1137

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Metadata

Authors
Piccirillo, C. A., & Shevach, E. M.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2001-08-01
Volume
167
Issue
3
Pages
1137-1140
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.167.3.1137
OpenAlex
W2133972276
Cited by
716
References
24
FWCI
16.16
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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