The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
Open accessAbstract
T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic (NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on (NOD x B6-RIP-B7-1)F1 islets. These cells proliferate specifically to NOD islets and kill NOD islets in vitro. The cells are restricted by H-2Kd, and all bear T cell antigen receptor encoded by V beta 6. When these CD8 T cell lines and clones are adoptively transferred to irradiated female NOD, young NOD-SCID, and CB17-SCID mice, diabetes occurs very rapidly, within 10 d of transfer and without CD4 T cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A cell culture model for T lymphocyte clonal anergy
Schwartz, R. H. (1990) · Science · doi:10.1126/science.2113314 · Cited by 1,857
The Role of the CD28 Receptor During T Cell Responses to Antigen
Linsley, P. S., & Ledbetter, J. A. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001203 · Cited by 1,298
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
Townsend, S. E., & Allison, J. P. (1993) · Science · doi:10.1126/science.7678351 · Cited by 1,136
Linsley, P. S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.3.721 · Cited by 1,127
Chen, L., Ashe, S., Brady, W. A., Hellström, I., Hellström, K. E., Ledbetter, J. A., McGowan, P., & Linsley, P. S. (1992) · Cell · doi:10.1016/s0092-8674(05)80059-5 · Cited by 1,050
Bottazzo, G. F., Dean, B. M., McNally, J. M., MacKay, E. H., Swift, P. G. F., & Gamble, D. R. (1985) · New England Journal of Medicine · doi:10.1056/nejm198508083130604 · Cited by 932
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.
Thompson, C. B., Lindsten, T., Ledbetter, J. A., Kunkel, S. L., Young, H. A., Emerson, S. G., Leiden, J. M., & June, C. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1333 · Cited by 659
Bendelac, A., Carnaud, C., Boitard, C., & Bach, J. F. (1987) · The Journal of experimental medicine · doi:10.1084/jem.166.4.823 · Cited by 569
Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.
Gimmi, C. D., Freeman, G. J., Gribben, J. G., Gray, G., & Nadler, L. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6586 · Cited by 548
Genetic analysis of autoimmune type 1 diabetes mellitus in mice
Todd, J. A., Aitman, T. J., Cornall, R. J., Ghosh, S., Hall, J. R. S., Hearne, C. M., Knight, A. M., Love, J. M., McAleer, M. A., Prins, J.-B., et al. (1991) · Nature · doi:10.1038/351542a0 · Cited by 493
Cited by
THE NOD MOUSE: A Model of Immune Dysregulation
Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113
Autoimmune disease: why and where it occurs
Marrack, P., Kappler, J., & Kotzin, B. L. (2001) · Nature Medicine · doi:10.1038/90935 · Cited by 609
Autoimmune Destruction of Pancreatic β Cells
Yoon, J.-W., & Jun, H.-S. (2005) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000178767.67857.63 · Cited by 308
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
Wiedeman, A. E., Muir, V. S., Rosasco, M. G., DeBerg, H. A., Presnell, S., Haas, B., Dufort, M. J., Speake, C., Greenbaum, C. J., Serti, E., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126595 · Cited by 168
Chapter 4 CD8+ T Cells in Type 1 Diabetes
Tsai, S., Shameli, A., & Santamaria, P. (2008) · Advances in Immunology · doi:10.1016/s0065-2776(08)00804-3 · Cited by 140
Metadata
- Authors
- Wong, F. S., Visintin, I., Wen, L., Flavell, R. A., & Janeway, C. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-01-01
- Volume
- 183
- Issue
- 1
- Pages
- 67-76
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2125985469
- Cited by
- 346
- References
- 41
- FWCI
- 17.85
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. https://app.cochat.ai/papers/10.1084/jem.183.1.67
- The paper
- Wong, F. S., Visintin, I., Wen, L., Flavell, R. A., & Janeway, C. A. (1996). CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.1.67
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
