The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Cutting Edge: Induction of IFN-γ Production but Not Cytotoxicity by the Killer Cell Ig-Like Receptor KIR2DL4 (CD158d) in Resting NK Cells
Abstract
Activated NK cells lyse tumor cells and virus-infected cells and produce IFN-γ upon contact with sensitive target cells. The regulation of these effector responses in resting NK cells is not well understood. We now describe a receptor, KIR2DL4, that has the unique property of inducing IFN-γ production, but not cytotoxicity, by resting NK cells in the absence of cytokines. In contrast, the NK cell-activation receptors CD16 and 2B4 induced cytotoxicity but not IFN-γ production. The induction by KIR2DL4 of IFN-γ production by resting NK cells was blocked by an inhibitor of the p38 mitogen-activated protein kinase signaling pathway, in contrast to the IL-2-induced IFN-γ secretion that was sensitive to inhibition of the extracellular signal-regulated kinase mitogen-activated protein kinase pathway. These results reveal a functional dichotomy (cytokine production vs cytotoxicity) in the response of resting NK cells, as dictated by the signals of individual receptors.
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Cites
NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
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Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
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Self-citationInterferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
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Ponte, M., Cantoni, C., Biassoni, R., Tradori-Cappai, A., Bentivoglio, G., Vitale, C., Bertone, S., Moretta, A., Moretta, L., & Mingari, M. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5674 · Cited by 364
Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
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On guard—activating NK cell receptors
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Cited by
Lanier, L. L. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115526 · Cited by 2,769
Natural killer cells and pregnancy
Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235
KIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity
Vilches, C., & Parham, P. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.092501.134942 · Cited by 986
Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential
Koopman, L. A., Kopcow, H. D., Rybalov, B., Boyson, J. E., Orange, J. S., Schatz, F., Masch, R., Lockwood, C. J., Schachter, A. D., Park, P. J., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030305 · Cited by 909
Human natural killer cell development and biology
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Metadata
- Authors
- Rajagopalan, S., Fu, J., & Long, E. O.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-08
- Volume
- 167
- Issue
- 4
- Pages
- 1877-1881
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1931291333
- Cited by
- 258
- References
- 21
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rajagopalan, S., Fu, J., & Long, E. O. (2001). Cutting Edge: Induction of IFN-γ Production but Not Cytotoxicity by the Killer Cell Ig-Like Receptor KIR2DL4 (CD158d) in Resting NK Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.167.4.1877
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