The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
A Protease-Activated Pathway Underlying Th Cell Type 2 Activation and Allergic Lung Disease
Abstract
The respiratory allergens that induce experimental Th cell type 2-dependent allergic lung inflammation may be grouped into two functional classes. One class of allergens, in this study termed type I, requires priming with adjuvants remote from the lung to overcome airway tolerogenic mechanisms that ordinarily preclude allergic responses to inhaled Ags. In contrast, the other, or type II, allergen class requires neither remote priming nor additional adjuvants to overcome airway tolerance and elicit robust allergic lung disease. In this study, we show in an experimental model that diverse type II allergens share in common proteolytic activity that is both necessary and sufficient for overcoming airway tolerance and induction of pulmonary allergic disease. Inactivated protease and protease-free Ag fragments showed no allergenic potency, demonstrating that only active protease acting on endogenous substrates was essential. Furthermore, induction of airway tolerance could be aborted and allergic lung disease established by simply adding purified protease to a type I allergen. Thus, exogenous proteases are common to type II allergens and may be generally required to overcome the innate resistance of the airway to Th cell type 2 activation and allergic inflammation, raising concern for their potential contribution to diseases such as asthma.
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Cited by
A mechanism for the initiation of allergen-induced T helper type 2 responses
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The link between fungi and severe asthma: A summary of the evidence
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Interleukin‐13 in asthma pathogenesis
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Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma
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Metadata
- Authors
- Kheradmand, F., Kiss, A., Xu, J., Lee, S.-H., Kolattukudy, P. E., & Corry, D. B.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11
- Volume
- 169
- Issue
- 10
- Pages
- 5904-5911
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2154719091
- Cited by
- 305
- References
- 61
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kheradmand, F., Kiss, A., Xu, J., Lee, S.-H., Kolattukudy, P. E., & Corry, D. B. (2002). A Protease-Activated Pathway Underlying Th Cell Type 2 Activation and Allergic Lung Disease. The Journal of Immunology. https://doi.org/10.4049/jimmunol.169.10.5904
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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