The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Attenuation of allergic airway inflammation in IL‐4 deficient mice
Abstract
Summary: To investigate the role of IL‐4 in vivo in allergic asthma, we developed a murine model of allergen‐induced airway inflammation. Repealed daily exposures of actively immunised C57BL/6 mice to aerosolized ovalbumin (OVA) induced a peribronchial inflammation and an increase in eosinophils and lymphocytes in bronchoalveolar‐lavage(BAL) fluid. In IL‐4 deficient (IL4−/−) mice, treated in the same way, there were substantially fewer eosinophils in BAL and much less peribronchial inflammation compared with wild type mice. In this model, mast cell deficient (W/W v) mice developed a similar degree of BAL eosinophilia and peribronchial inflammation as wild type mice, demonstrating that the mast cell is not required for the induction of chronic airway inflammation. In contrast, BAL eosinophilia and airway inflammation were absent in OVA‐treated MHC ClassII deficient (B6.Aa−/−) mice which lack mature CD4+ T lymphocytes. In conclusion, these results indicate that IL‐4 is a central mediator of allergic airway inflammation, regulating antigen‐induced eosinophil recruitment into the airways by a T cell dependent mechanism.
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Citations
Cites
Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma
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Eosinophilic Inflammation in Asthma
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The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
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Mucosal Inflammation in Asthma
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Self-citationMast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores
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Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions.
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Cited by
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673
Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthaei, K. I., & Young, I. G. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.1.195 · Cited by 1,370
MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,017
Rothenberg, M. E. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805283382206 · Cited by 834
Metadata
- Authors
- BRUSSELLE, G. G., KIPS, J. C., TAVERNIER, J. H., VAN DER HEYDEN, J. G., CUVELIER, C. A., PAUWELS, R. A., & BLUETHMANN, H.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 1994-01
- Volume
- 24
- Issue
- 1
- Pages
- 73-80
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W2109032237
- Cited by
- 431
- References
- 35
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- BRUSSELLE, G. G., KIPS, J. C., TAVERNIER, J. H., VAN DER HEYDEN, J. G., CUVELIER, C. A., PAUWELS, R. A., & BLUETHMANN, H. (1994). Attenuation of allergic airway inflammation in IL‐4 deficient mice. Clinical & Experimental Allergy. https://doi.org/10.1111/j.1365-2222.1994.tb00920.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
